Abraxane

Q: What is the difference between Taxol and Abraxane?

Abraxane is a different form of paclitaxel than Taxol, they are both taxanes however Taxol uses a solvent called Cremophor EL to dissolve its main ingredients so the medicine can enter the bloodstream.

Q: What does Abraxane do to cancer?

ABRAXANE works by inhibiting the function of microtubules, which are proteins that help cells divide. It is a systemic treatment, which means it is used to treat <a href="https://www.withpower.com/clinical-trials/cancer">cancer</a> that has spread to other parts of the body.

Q: What is Abraxane used for?

metastatic <a href="https://www.withpower.com/clinical-trials/melanoma">melanoma</a> Nab-paclitaxel is a chemotherapy drug that is also known by its brand name, Abraxane. It combines the chemotherapy drug paclitaxel with a protein called albumin. It is a treatment for <a href="https://www.withpower.com/clinical-trials/breast-cancer">breast cancer</a> that has spread and metastatic melanoma.

Q: Do you lose your hair with Abraxane?

Some of the more common side effects that have been reported with ABRAXANE include hair loss, numbness and tingling in the extremities, and <a href="https://www.withpower.com/clinical-trials/pain">pain</a> or weakness in the hands or feet.

Neoplasm Metastasis, refractory Testicular germ cell cancer, advanced Thymoma + 19 more

Treatment

11 FDA approvals

20 Active Studies for Abraxane

Treatment for

Neoplasm Metastasis

What is Abraxane

Paclitaxel

The Generic name of this drug

Treatment Summary

Paclitaxel, sold under the brand name Taxol, is a chemotherapy drug used to treat various cancers. It was first discovered in the bark of the Pacific yew tree in 1971 and is available as an intravenous solution or the newer formulation Abraxane, which contains albumin-bound paclitaxel. Paclitaxel works by inhibiting cell growth and division, preventing cancer cells from multiplying.

Paclitaxel

is the brand name

image of different drug pills on a surface

Abraxane Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Paclitaxel

2001

Approved as Treatment by the FDA

Paclitaxel, also known as Paclitaxel, is approved by the FDA for 11 uses which include Non-Small Cell Lung Carcinoma (NSCLC) and Metastatic Non-Small Cell Lung Cancer .

Non-Small Cell Lung Carcinoma (NSCLC)

Used to treat Non-Small Cell Lung Carcinoma (NSCLC) in combination with Cisplatin

Metastatic Non-Small Cell Lung Cancer

Used to treat Metastatic Non-Small Cell Lung Cancer in combination with Carboplatin

Advanced Ovarian Cancer

Used to treat Advanced Ovarian Cancer in combination with Cisplatin

Metastatic Breast Cancer

Pancreatic Adenocarcinoma Metastatic

Used to treat Pancreatic Adenocarcinoma Metastatic in combination with Gemcitabine

Neoplasm Metastasis

Used to treat Pancreatic Adenocarcinoma Metastatic in combination with Gemcitabine

Carcinoma, Non-Small-Cell Lung

Used to treat Locally Advanced Non-Small Cell Lung Cancer in combination with Carboplatin

Malignant Neoplasms

Used to treat Metastatic Non-Small Cell Lung Cancer in combination with Carboplatin

Non-Small Cell Lung Cancer

Used to treat Non-Small Cell Lung Carcinoma (NSCLC) in combination with Cisplatin

Metastatic Breast Cancer

Ovarian Neoplasms

Used to treat Advanced Ovarian Cancer in combination with Cisplatin

Effectiveness

How Abraxane Affects Patients

Paclitaxel is an antineoplastic agent typically used to treat ovarian cancer, breast cancer, and other types of cancer. Paclitaxel works by forming and stabilizing microtubules in cells, which stops the normal reorganization of microtubules that are needed for cell functions. This can lead to the formation of abnormal microtubule structures during cell division.

How Abraxane works in the body

Paclitaxel disrupts the normal functioning of microtubules, which are an important part of a cell's structure. Paclitaxel binds to the beta subunit of tubulin, which makes up microtubules, and prevents them from disassembling. This makes it difficult for the cell to move molecules around, which is essential for cell functioning. Paclitaxel also binds to a protein called Bcl-2, which stops programmed cell death, and prevents it from working. This leads to cell death in cancer cells.

When to interrupt dosage

The portion of Abraxane is contingent upon the determined condition, including advanced Soft Tissue Sarcoma (STS), Malignant Neoplasms and Ovarian Cancer. The measure of dosage can be found in the table below, depending on the method of delivery (e.g. Liquid - Intravenous or Injection, solution - Intravenous).

Condition

Dosage

Administration

Sarcoma