Amnion-Chorion Membrane for Palate Wound Healing
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing if a special tissue bandage helps mouth surgery wounds heal better and reduces pain compared to a common gauze. The study focuses on patients who need healing in the roof of their mouth after surgery. The special tissue bandage has been used in various oral surgeries for tissue regeneration.
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What safety data exists for amnion-chorion membrane treatment?
The safety data for amnion-chorion membrane treatment, including its use under various names like dehydrated human amnion/chorion membrane (dHACM), indicates it is generally safe. A case series involving five patients with chronic non-healing wounds treated with dHACM reported no adverse events, suggesting it is a safe and effective therapy. Additionally, a study comparing amnion-chorion membrane to collagen membrane in alveolar ridge preservation found no significant differences in healing or bone vitality, further supporting its safety. Overall, the available studies and literature reviews suggest that amnion-chorion membrane products are safe for clinical use in wound healing.12345
Is the amnion-chorion membrane a promising treatment for palate wound healing?
What data supports the idea that Amnion-Chorion Membrane for Palate Wound Healing is an effective treatment?
The available research shows that the Amnion-Chorion Membrane is effective for wound healing. One study focused on its use in cleft palate repair and found it to be safe and effective for closing wounds after surgery. Another study highlighted its success in treating nonhealing wounds, showing that it helps reduce inflammation and speeds up healing. Additionally, a pilot study compared healing with and without the membrane in oral surgery and found that the membrane improved healing outcomes. These findings suggest that the Amnion-Chorion Membrane is a beneficial treatment for palate wound healing.367910
Who Is on the Research Team?
Brian L Mealey, DDS, MS
Principal Investigator
University of Texas Health Science Center San Antonio
Are You a Good Fit for This Trial?
This trial is for adults aged 18-89 needing gum surgery in the mouth area from back molar to back molar, whether they have teeth, implants, or none. Participants can be non-smokers or light smokers (less than 10 cigarettes a day), including women who are not pregnant and either post-menopausal, had tubal ligation/hysterectomy, or use contraception. They must also be able to follow up and own a smartphone.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo periodontal plastic surgery with either Amnio-Chorion Membrane or ActCel Cellulose Gauze applied to the palatal donor site
Follow-up
Participants are monitored for wound healing and pain perception post-surgery
What Are the Treatments Tested in This Trial?
Interventions
- ActCel Cellulose Gauze
- Amnion-Chorion Membrane
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center at San Antonio
Lead Sponsor