Educational Video Intervention for PrEP Uptake in Sexual Minority Groups

(PrEP4Kink Trial)

Overseen By Alejandra M Hilbert, BA

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: The Alternative Sexualities Health Research Alliance

Must not be taking: PrEP

Disqualifiers: HIV positive, Renal failure, Pregnant, others

Stay on Your Current Meds You can continue your current medications while participating

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 6

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to evaluate how well certain educational videos assist people in kink communities in starting and maintaining PrEP, a medication that helps prevent HIV. The study compares the impact of generic videos versus kink-focused videos on attitudes and beliefs about PrEP. Participants will watch either a kink-focused video, a generic video, or a mix of both. Those who have recently engaged in consensual kink activities, do not know their HIV status, and have not used PrEP before may be suitable for this trial. As an unphased trial, this study offers a unique opportunity to contribute to research that could tailor HIV prevention strategies to specific communities.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It mainly focuses on PrEP use and does not mention other medications.

What prior data suggests that this video intervention is safe?

Research shows that educational videos, like those in this study, are generally safe for participants. Designed to inform and educate, these videos are tailored for specific audiences.

Studies have found that similar video programs have been well-received by participants, with no known negative effects from watching them. Participants in the trial should not experience any harmful physical effects from the videos.

The main goal is to assess the effectiveness of the videos in increasing awareness and acceptance of Pre-Exposure Prophylaxis (PrEP), a medication that helps prevent HIV. While the safety of the videos is not a concern, the researchers aim to determine how well they help people understand and decide to use PrEP. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Educational Video Intervention for PrEP uptake because it uses a targeted approach to address the unique needs of sexual minority groups. Unlike typical PrEP educational methods, which often use generic messaging, this intervention includes kink-focused content that could resonate more with its audience. By tailoring the information and presentation style, this method aims to increase understanding and acceptance of PrEP, potentially leading to higher uptake rates. This personalized strategy could bridge the gap between awareness and action, making preventative healthcare more effective for these communities.

What evidence suggests that this video intervention is effective for increasing PrEP uptake in sexual minority groups?

Research has shown that educational videos can help people learn about and start using PrEP, a medication that helps prevent HIV. One study found that a video increased the number of women clicking on PrEP resources. Another study used culturally relevant videos, which boosted interest in PrEP among young Black women. These findings suggest that relatable videos might encourage more people to use PrEP. The current trial examines different video interventions, including a kink-focused video, to see if they can increase PrEP use in certain communities. Participants in this trial will divide into groups receiving varying exposures to either the kink-focused video or a generic/standard video to assess their impact on PrEP uptake. ^{1 2 6 7 8}

Are You a Good Fit for This Trial?

This trial is for adults who are involved in kink activities, weigh at least 35 kg, don't know or have a negative HIV status, and haven't used PrEP before. They must understand English well enough to comprehend study materials and give informed consent. People under 18, those with positive HIV status or serious side effects from previous PrEP use, renal failure patients, pregnant individuals, current PrEP users, or participants in other PrEP trials cannot join.

Inclusion Criteria

English-language proficiency sufficient to understand the study instruments

Successful completion of screening checklist to indicate engagement in consensual kink activities such as power exchange, bondage, sadomasochism, or fetish activities

Report negative HIV serostatus or report unknown HIV serostatus

Exclusion Criteria

Enrolled in an investigational trial of PrEP medication

Self-reported positive HIV serostatus

Currently pregnant

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants receive educational interventions, including kink-focused and generic videos, to increase PrEP uptake

12 months

3-5 exposures to video interventions

Follow-up

Participants are monitored for PrEP uptake, adherence, and changes in health beliefs over time

12 months

Surveys at 3, 6, 9, and 12 months

What Are the Treatments Tested in This Trial?

Interventions

• video informational/educational intervention

Trial Overview The study tests how different educational materials (generic vs. kink-focused videos) affect the uptake of Pre-Exposure Prophylaxis (PrEP) among BDSM-involved individuals over a year. It aims to make the information relatable to this group and see if it changes their health beliefs about using PrEP to prevent HIV.

How Is the Trial Designed?

Group I: Group D Experimental Treatment 1 Intervention

group that receives 2 exposures to the generic / standard video, and later 1 exposure to the kink-focused video

Group II: Group C Experimental Treatment 1 Intervention

group that receives 1 exposure to the generic / standard video, and later 2 exposures to the kink-focused video

Group III: Group B Experimental Treatment 1 Intervention

control group, receiving no exposure to the kink-focused video, but seeing the generic / standard video

Group IV: Group A Experimental Treatment 1 Intervention

experimental group, receiving 3 exposures to the kink-focused video intervention

Who Is Running the Clinical Trial?

The Alternative Sexualities Health Research Alliance

Lead Sponsor

Trials

2

Recruited

970+

Citations

1. withpower.com withpower.com/trial/phase-pre-exposure-prophylaxis-3-2023-1b629

Educational Video Intervention for PrEP Uptake in Sexual ... Trial Overview The study tests how different educational materials (generic vs. kink-focused videos) affect the uptake of Pre-Exposure Prophylaxis (PrEP) among ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9308066/

Developing Educational Animations on HIV Pre-exposure ... Two animation storyboards about PrEP for women were created by academic stakeholders (eg, HIV clinical experts, educators, and HIV peer counselors), one for ...

3. publichealth.jmir.org publichealth.jmir.org/2025/1/e67367

Intervention Study With Vlogs Shared on Social Media The study used social media vlogs with links to local PrEP resources, reaching 110.8k women and resulting in 15,952 link clicks.

4. researchgate.net researchgate.net/publication/396117723_Put_Yourself_First_Acceptability_of_a_Culturally_Tailored_eHealth_Video_Intervention_to_Promote_PrEP_Awareness_and_Uptake_Among_Young_Black_Women_Preprint

Acceptability of a Culturally Tailored eHealth Video ... Put Yourself First: Acceptability of a Culturally Tailored eHealth Video Intervention to Promote PrEP Awareness and Uptake Among Young Black ...

5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC6134229/

Empowering With PrEP (E-PrEP), a Peer-Led Social Media ... Current data indicate that young black and Latinx men have lower rates of PrEP uptake than other groups of men [15], suggesting disparities in ...

6. journals.sagepub.com journals.sagepub.com/doi/abs/10.1177/15404153231210436

Culturally Targeted Video Intervention to Increase PrEP ... This two-arm pilot randomized controlled trial study aimed to assess the feasibility and preliminary efficacy of delivering an online culturally targeted video ...

7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11812645/

Increasing pre-exposure prophylaxis (PrEP) in primary care Patient components include a tailored PrEP educational video and HIV risk assessment. ... PrEP informational video for patients. Patient knowledge and awareness ...

8. ajpmonline.org ajpmonline.org/article/S0749-3797(21)00358-5/fulltext

Pre-exposure Prophylaxis Uptake, Adherence, and ... This narrative review examines the latest interventions and programs to improve all 3 stages of PrEP adherence and reviews ongoing studies to promote effective ...