Visuomotor Learning Task for Stroke Recovery
Trial Summary
What is the purpose of this trial?
After a stroke, plasticity occurs in the brain from microscopic to network level with positive but also negative consequences for functional recovery. Why post-stroke plasticity takes a beneficial or a maladaptive direction is still incompletely understood. Because the biological mechanisms underlying sensorimotor learning parallel those observed during recovery, learning mechanisms could be potential modifiers of post-stroke neuroplasticity and have a discrete mal-/adaptive impact on the recovery of sensorimotor function. This project seeks to further the understanding of the link between brain circuits that control the integration of new information during procedural learning in the injured brain and those circuits that are involved in adaptive plastic changes during recovery of sensorimotor function post-stroke. The project's methodological approach will allow the characterization of procedural learning-related neural network dynamics based on functional magnetic resonance imaging (MRI) in human volunteers with and without neurologically impairment post-stroke. Through multivariate integration of behavioral and biological descriptors of sensorimotor recovery, the project will investigate the association between motor learning-related network dynamics and descriptors of recovery.
Will I have to stop taking my current medications?
If you are taking tricyclic anti-depressants or neuroleptic medication, you will need to stop taking them to participate in this trial.
What data supports the effectiveness of the treatment Visuomotor learning task for stroke recovery?
Research shows that learning-based sensorimotor training can improve upper limb function in stroke patients, and motor skill learning is important for recovery. Studies using similar visuomotor tasks have shown brain activity changes that correlate with motor skill improvements, suggesting potential benefits for stroke recovery.12345
How does the Visuomotor learning task treatment differ from other stroke recovery treatments?
The Visuomotor learning task is unique because it focuses on improving motor skills through a specific learning paradigm that involves a balance between speed and accuracy, which can lead to different patterns of brain activation and neuroplasticity. This approach targets specific brain areas like the premotor cortex, which are crucial for motor control and recovery, making it distinct from general physical therapy that may not specifically engage these neural pathways.23567
Eligibility Criteria
This trial is for adults over 18 who are right-handed and have had a stroke at least 6 months ago, with the ability to grip with their hand. They must not have severe communication difficulties, MRI risks, substance use disorders, certain types of multiple or cerebellar strokes, other neurological issues affecting the arm, dementia history, uncontrolled high blood pressure or be taking specific antidepressants or antipsychotic drugs.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Learning Session
Participants undergo a learning session to assess changes in visuomotor grip force adjustment and brain activation
Follow-up
Participants are monitored for changes in sensorimotor recovery and brain activation post-learning session
Treatment Details
Interventions
- Visuomotor learning task
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical University of South Carolina
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborator
National Institutes of Health (NIH)
Collaborator