Sprint Interval Training for Spinal Cord Injury

(SIT Trial)

CG
AF
Overseen ByAaron Flaster
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Washington
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore how different sprint interval training (SIT) methods can increase physical activity for people with new spinal cord injuries during and after rehabilitation. It will test three approaches: sprint training during rehab, adding a home exercise machine, and combining these with motivational support. Researchers aim to determine if these methods boost exercise levels and improve quality of life. The trial seeks participants with spinal cord injuries who can use an arm exercise machine and are currently in a rehab program. As an unphased trial, this study offers participants the chance to contribute to innovative research that could enhance rehabilitation strategies for spinal cord injuries.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that sprint interval training (SIT) is generally safe for people with spinal cord injuries. In one study, participants improved their fitness and muscle strength without serious side effects. Another study on high-intensity interval training (HIIT) found it was well-received, though some experienced increased shoulder pain. Those using a home exercise device found the training doable and safe, with no serious problems reported.

Adding motivational interviewing to the exercise plan aims to help people maintain their routine. No evidence suggests this addition is harmful, and it might make it easier for participants to consistently engage in their exercises.

Overall, these treatments appear well-tolerated, with mild shoulder discomfort as the main issue for some. Most find this type of exercise acceptable and helpful for their recovery.12345

Why are researchers excited about this trial's treatments?

Researchers are excited about Sprint Interval Training (SIT) for spinal cord injury because it presents a new approach to rehabilitation that may enhance recovery outcomes. Unlike standard rehabilitation therapies, which typically focus on steady, moderate exercise, SIT involves short bursts of high-intensity exercise, potentially improving cardiovascular health and muscle strength more efficiently. Additionally, some variations of SIT being tested incorporate the use of a consumer-grade ergometer for home use, promoting continuous engagement in physical activity outside of clinical settings. The inclusion of Motivational Interviewing sessions is also noteworthy, as it aims to boost patient motivation and adherence to exercise regimens. Researchers are hopeful that these innovations can lead to more effective and sustainable recovery routines for individuals with spinal cord injuries.

What evidence suggests that this trial's treatments could be effective for increasing physical activity after spinal cord injury?

Research shows that sprint interval training (SIT) can significantly enhance physical abilities for people with spinal cord injuries. One study found that five weeks of SIT improved physical abilities as much as moderate-intensity continuous training (MICT) but required less time. This trial includes several treatment arms: one where participants engage in SIT alone, another where they use a home ergometer in addition to SIT, and a third where they receive motivational interviewing alongside SIT and ergometer use. A home ergometer, similar to a stationary bike for the arms, can help maintain these benefits after hospital discharge. Motivational interviewing with a counselor can also increase motivation to exercise regularly. Together, these methods aim to keep participants active and improve quality of life after rehabilitation.24567

Who Is on the Research Team?

DA

Deborah A Crane, MD, MPH

Principal Investigator

University of Washington

Are You a Good Fit for This Trial?

Adults aged 18-65 with a new spinal cord injury (SCI) below the C2 vertebra, classified as AIS A-C, who are currently in acute inpatient rehabilitation at Harborview Medical Center and can use an arm ergometer. Excluded are those with shoulder injuries, other conditions preventing safe participation, uncontrolled diabetes type II, or unstable heart disease.

Inclusion Criteria

My spinal cord injury is classified between AIS A to C.
My spinal cord injury is below the second neck vertebra.
I am currently in acute inpatient rehab for spinal cord injury at Harborview.
See 1 more

Exclusion Criteria

Any other medical condition that would preclude safe participation in study procedures.
I have a heart condition that changes or gets worse quickly.
My type II diabetes is not well-managed.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Inpatient Rehabilitation

Participants undergo Sprint Interval Training (SIT) approximately three times per week during inpatient rehabilitation

4 weeks
3 sessions per week (in-person)

Post-Discharge Home Exercise

Participants continue SIT at home using a consumer grade ergometer, with motivational interviewing sessions provided monthly

6 months
6 monthly telehealth sessions

Follow-up

Participants are monitored for physical activity and other outcomes at 6 months post-discharge

1 week
1 visit (virtual or in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Home Ergometer (ERGO)
  • Motivational Interviewing (MI)
  • Sprint Interval Training (SIT)
Trial Overview The study is testing three approaches to boost physical activity during/after inpatient rehab for SCI: Sprint Interval Training (SIT) on an arm crank ergometer; SIT plus a home-use ergometer; and SIT with the ergometer plus motivational interviews to encourage exercise adherence.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Active Control
Group I: Spring Interval Training (SIT)Experimental Treatment1 Intervention
Group II: SIT + ERGO + MIExperimental Treatment3 Interventions
Group III: SIT + ERGOExperimental Treatment2 Interventions
Group IV: Usual CareActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Washington

Lead Sponsor

Trials
1,858
Recruited
2,023,000+

The Craig H. Neilsen Foundation

Collaborator

Trials
62
Recruited
3,100+

Published Research Related to This Trial

Hybrid High-Intensity Interval Training (HIIT) using Functional Electrical Stimulation (FES) was found to be safe and well-accepted by participants with spinal cord injuries, with no serious adverse events reported during the 8-week study involving 8 participants.
Participants experienced a significant 17% increase in peak oxygen uptake (VO2peak) and reported improvements in leisure time physical activity and quality of life, indicating that this training method can enhance physical fitness and overall well-being for individuals with SCI.
Hybrid high-intensity interval training using functional electrical stimulation leg cycling and arm ski ergometer for people with spinal cord injuries: a feasibility study.Vestergaard, M., Jensen, K., Juul-Kristensen, B.[2022]
A systematic review of 6 studies found no overall difference in time trial (TT) performance improvements between high-intensity interval training (HIIT) and sprint interval training (SIT), indicating both methods are similarly effective for trained individuals.
However, long-duration HIIT (≥ 4 minutes) showed a 2% greater improvement in TT performance compared to SIT, suggesting that longer work intervals may be more beneficial for enhancing performance.
Effect of High-Intensity Interval Training Versus Sprint Interval Training on Time-Trial Performance: A Systematic Review and Meta-analysis.Rosenblat, MA., Perrotta, AS., Thomas, SG.[2021]
High-intensity interval training (HIIT) and sprint interval training resulted in higher peak oxygen uptake and heart rates compared to moderate intensity exercise in 9 adults with spinal cord injury, indicating that these interval training methods can effectively enhance cardiorespiratory fitness in this population.
Participants preferred interval training over moderate exercise, suggesting that HIIT may be a more engaging and feasible exercise option for individuals with spinal cord injury, warranting further research into its long-term benefits.
Within-session responses to high-intensity interval training in spinal cord injury.Astorino, TA., Thum, JS.[2022]

Citations

1.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/31462757/
Sprint interval training versus moderate-intensity ...Five weeks of SIT improved physical capacity to the same extent as MICT in individuals with sub-acute SCI, despite a significantly lower time commitment ...
Feasibility of a Sprint Interval Training Program During ...This study will assess the feasibility and efficacy of 3 treatments to increase physical activity during and after inpatient rehabilitation (IPR) for new ...
(PDF) Sprint interval training versus moderate-intensity ...Objectives: To evaluate the effectiveness of a 5-week sprint interval training (SIT) protocol on an arm-crank ergometer in individuals with sub- ...
The Effects of Two Weeks of Arm Crank Sprint Interval ...In conclusion, two weeks of ACE SIT was effective at reducing NEFA in men with SCI, but did not improve insulin sensitivity or glucose levels. These data ...
Sprint Interval Training for Spinal Cord Injury (SIT Trial)Participants experienced a significant 17% increase in peak oxygen uptake (VO2peak) and reported improvements in leisure time physical activity and quality of ...
Benefits and interval training in individuals with spinal cord ...The benefits reported with FES-LCE include increased lean-to-fat mass ratio, enhanced peripheral blood flow and vasoreactivity, and increased ...
Effect of high-intensity exercise training on functional recovery ...Both conditions led to improvements in insulin sensitivity, aerobic capacity, muscle strength, and lipids in patients with spinal cord injury.
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