30 Participants Needed

Sleep Deprivation for Heart Function During Exercise

JB
Overseen ByJulian Bommarito, MSc
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Guelph
Must be taking: Oral contraceptives
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it does exclude people who are on chronic medications other than oral contraceptives. This suggests that you might need to stop other chronic medications to participate.

What data supports the effectiveness of the treatment Partial Sleep Deprivation for heart function during exercise?

Research shows that partial sleep deprivation can lead to increased heart rate and ventilation during exercise, which may affect heart function. However, it also suggests that sleep deprivation primarily alters psychological responses to exercise rather than physiological ones.12345

Is sleep deprivation generally safe for humans during exercise?

Sleep deprivation can increase heart rate and breathing during exercise and may lead to muscle and heart strain. It can also reduce the body's ability to use energy effectively, making exercise feel harder. However, it does not seem to affect overall heart and lung function during exercise.12678

How does the treatment of partial sleep deprivation differ from other treatments for heart function during exercise?

Partial sleep deprivation is unique because it involves intentionally reducing sleep to study its effects on heart function during exercise, unlike other treatments that might focus on medication or lifestyle changes. This approach examines how lack of sleep affects the body's autonomic (automatic body functions) and endocrine (hormone-related) systems, which can influence heart rate and exercise performance.268910

What is the purpose of this trial?

The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50 females). The secondary outcome is to assess sex differences. The main questions it aims to answer are:* Do reductions in plasma volume drive reductions in cardiac output and therefore blood pressure during exercise following a night of partial sleep deprivation?* Do sex differences exist?Participants will:* Visit the lab after a night of normal sleep and a night of partial sleep deprivation.* Keep a daily diary of their sleep and food/beverage intake.* Perform maximal and submaximal exercise on a cycle ergometer.

Research Team

JB

Julian Bommarito, MSc

Principal Investigator

University of Guelph

PM

Philip Millar, PhD

Principal Investigator

University of Guelph

Eligibility Criteria

This trial is for young, healthy adults interested in how lack of sleep affects heart function during exercise. Participants will need to visit the lab after both a normal night's sleep and a night with less sleep, keep track of their sleep and eating habits, and do cycling exercises.

Inclusion Criteria

Able to abide by sleep protocols for all visits
No history of smoking (within the past 3 months)
Able to engage in physical activity assessed through the physical activity readiness questionnaire (PAR-Q+)
See 4 more

Exclusion Criteria

Has a history of smoking (within the past 3 months)
I am on long-term medication other than birth control pills.
Unable to abide by sleep protocols for any testing visit
See 4 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Baseline Assessment

Participants undergo assessment of maximal oxygen uptake to determine aerobic fitness and metabolic exercise intensity zones

1 visit
1 visit (in-person)

Intervention

Participants visit the lab after a night of normal sleep and a night of partial sleep deprivation to perform cycling exercise and have hemodynamics and plasma volume measured

2 visits
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the intervention

1-2 weeks

Treatment Details

Interventions

  • Partial Sleep Deprivation
Trial Overview The study aims to see if not getting enough sleep leads to lower blood pressure because of reduced heart output when exercising. It also looks at whether men and women react differently to this kind of stress.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Partial sleep deprivationExperimental Treatment1 Intervention
During this arm, participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).
Group II: Normal sleepActive Control1 Intervention
During this arm, participants will be asked to come to the lab for testing after a night of normal sleep. Normal sleep will be defined as participants habitual sleep-wake timing.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Guelph

Lead Sponsor

Trials
87
Recruited
15,100+

Findings from Research

High-intensity interval exercise (HIIE) can improve cardiovascular function, as measured by flow-mediated dilation (FMD), even after acute-partial sleep deprivation in healthy males, suggesting a protective effect against cardiovascular disease.
In a study with 15 participants, both HIIE after a good night's sleep and after sleep deprivation resulted in similar improvements in FMD, indicating that engaging in HIIE may help mitigate some negative cardiovascular effects of sleep loss.
Acute partial sleep deprivation and high-intensity interval exercise effects on postprandial endothelial function.Papadakis, Z., Forsse, JS., Peterson, MN.[2021]
After a night of partial sleep deprivation, highly trained endurance athletes experienced increased heart rate and ventilation during exercise, indicating a negative impact on cardiovascular and respiratory responses.
Triazolam-induced sleep improved sleep quality by increasing stage 2 sleep and reducing wakefulness, but did not fully restore performance levels compared to baseline sleep, suggesting that sleep quality is crucial for optimal exercise performance.
Effects of sleep disturbances on subsequent physical performance.Mougin, F., Simon-Rigaud, ML., Davenne, D., et al.[2019]
Acute sleep loss does not significantly affect physiological measures like oxygen uptake, carbon dioxide production, or heart rate during exercise, indicating that the body's physical performance remains stable despite lack of sleep.
However, sleep deprivation increases perceived exertion during moderate and heavy exercise, suggesting that while physical capabilities may not change, the psychological experience of effort does, which could impact exercise performance.
Exercise after sleep deprivation.Martin, BJ., Gaddis, GM.[2019]

References

Acute partial sleep deprivation and high-intensity interval exercise effects on postprandial endothelial function. [2021]
Effects of sleep disturbances on subsequent physical performance. [2019]
Exercise after sleep deprivation. [2019]
[Disturbance of sports performance after partial sleep deprivation]. [2006]
Hormonal responses to exercise after partial sleep deprivation and after a hypnotic drug-induced sleep. [2018]
One night of partial sleep deprivation increased biomarkers of muscle and cardiac injuries during acute intermittent exercise. [2022]
Sleep deprivation and cardiorespiratory function. Influence of intermittent submaximal exercise. [2019]
Sleep deprivation and the effect on exercise performance. [2018]
Effects of sleep deprivation on autonomic and endocrine functions throughout the day and on exercise tolerance in the evening. [2013]
10.United Statespubmed.ncbi.nlm.nih.gov
Effects of High-Intensity Interval Exercise and Acute Partial Sleep Deprivation on Cardiac Autonomic Modulation. [2021]
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