VR-Based Mobility Training for Low Vision

(VR-IOMS Trial)

No longer recruiting at 1 trial location
LL
EL
Overseen ByEllen L Bowman, PhD
Age: Any Age
Sex: Any
Trial Phase: Academic
Sponsor: University of Alabama at Birmingham
Approved in 1 JurisdictionThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores the effectiveness of virtual reality (VR) technology in teaching people with low vision to safely navigate streets. Participants will be divided into three groups to compare learning from VR-based training (Orientation and Mobility Training with VR-IOMSs), traditional human-led training, and educational videos. The trial seeks individuals with stable visual impairment who haven't received formal navigation training and who struggle with tasks like crossing streets. The goal is to determine if VR can match or surpass human instruction in improving mobility skills. As an unphased trial, this study offers participants the opportunity to contribute to innovative research that could enhance mobility training for those with visual impairments.

Will I have to stop taking my current medications?

The trial protocol does not specify whether you need to stop taking your current medications. However, if you are under aggressive treatment for ocular diseases, such as receiving VEGF injections, you may not be eligible to participate.

What prior data suggests that these VR-based mobility training methods are safe for low vision patients?

Research has shown that virtual reality-based training, such as the VR-IOMS being tested, is generally safe for people with low vision. Studies have found that virtual reality training is as effective as practicing in real-life settings. This approach is not only helpful but also well-tolerated.

The VR-IOMS allows individuals to learn and practice crossing streets and navigating outdoor environments without actual traffic exposure. This setup provides a safe and controlled environment, reducing the risk of accidents or injuries during training. Past research has not reported any serious problems associated with this type of training.

Overall, virtual reality training for orientation and mobility appears to be a safe and promising method to help people with low vision improve their skills.12345

Why are researchers excited about this trial?

Researchers are excited about VR-based mobility training for low vision because it offers a cutting-edge approach using Virtual Reality-based Intelligent Orientation and Mobility Specialists (VR-IOMSs). Unlike traditional methods that rely on human Certified Orientation and Mobility Specialists (COMS) in real-world settings, this virtual reality system uses intelligent, computer-controlled programs to help participants learn crucial navigation skills in simulated environments. This innovative method not only provides a safe and controlled space for practice but also allows for personalized, on-demand training, which could revolutionize how individuals with low vision gain independence.

What evidence suggests that this trial's treatments could be effective for low vision?

This trial will compare different methods of Orientation and Mobility (O&M) training for individuals with low vision. Studies have shown that virtual reality (VR) creates lifelike environments that help people with low vision improve their O&M skills. Participants in this trial may receive VR-based training with VR-IOMS, which effectively simulates real-world situations for practicing important skills safely. Early findings suggest that these VR systems help users better judge traffic and learn how to navigate outdoors. Another group in this trial will receive traditional O&M training with human specialists, which has already been proven to greatly improve travel independence and quality of life for people with visual impairments. Both methods aim to enhance navigation skills, but VR-IOMS offers a unique, technology-driven approach with promising early results.678910

Who Is on the Research Team?

LL

Lei Liu, PhD

Principal Investigator

University of Alabama at Birmingham

Are You a Good Fit for This Trial?

This trial is for individuals with low vision who have not had formal orientation and mobility (O&M) training, can hear normally or with correction, aim to improve O&M skills, and have stable late-onset visual impairment. They should be able to perform basic tasks like using a mouse or joystick and walking short distances. People with rapidly progressing eye diseases, aggressive treatments ongoing, congenital impairments, existing mastery of the skills being taught, difficulty speaking English, or a history of seizures/motion sickness cannot join.

Inclusion Criteria

You need to be able to use a computer mouse or a joystick.
My vision loss occurred later in life and has not changed recently.
I have not received formal orientation and mobility training.
See 6 more

Exclusion Criteria

Participants will be excluded from the training for the skills that they already master.
Patients with congenital visual impairment will be excluded.
I am receiving eye injections for a retinal disease.
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks
1 visit (in-person)

Pre-training Evaluation

Participants are evaluated by COMSs in real streets to assess baseline O&M task performance

1 week
1 visit (in-person)

Training

Participants undergo training using VR-IOMS, human COMS, or watch educational videos

1 week
Multiple sessions (in-person or virtual)

Post-training Evaluation

Participants are evaluated by COMSs in real streets to assess O&M task performance after training

Within 3 days after training
1 visit (in-person)

Follow-up

Participants are monitored for retention of training effects and safety in O&M tasks

3 months
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • No Orientation and Mobility Training
  • Orientation and Mobility Training with COMS
  • Orientation and Mobility Training with VR-IOMSs
Trial Overview The study tests three methods for teaching O&M skills to those with low vision: learning from Virtual Reality-based Intelligent Orientation and Mobility Specialists (VR-IOMS), from human specialists in real streets (COMS), or watching educational videos as a control group. The effectiveness will be measured by comparing participants' abilities before and after training in real street evaluations.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Orientation and Mobility Training with VR-IOMSsExperimental Treatment1 Intervention
Group II: Orientation and Mobility Training with COMSActive Control1 Intervention
Group III: No Orientation and Mobility TrainingPlacebo Group1 Intervention

Orientation and Mobility Training with VR-IOMSs is already approved in United States for the following indications:

🇺🇸
Approved in United States as VR-IOMSs for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alabama at Birmingham

Lead Sponsor

Trials
1,677
Recruited
2,458,000+

New Jersey Institute of Technology

Collaborator

Trials
11
Recruited
1,100+

Alabama Institute for Deaf and Blind

Collaborator

Published Research Related to This Trial

A new standardized orientation and mobility training protocol for individuals with low vision has been developed, incorporating both current practices and theoretical frameworks to enhance its effectiveness.
The training consists of two face-to-face sessions and a follow-up call, and is currently being evaluated for its acceptability and effectiveness in a randomized controlled trial.
Orientation and mobility training for adults with low vision: a new standardized approach.Zijlstra, GA., Ballemans, J., Kempen, GI.[2022]
The review identified only two small quasi-randomised trials assessing orientation and mobility (O&M) training for adults with low vision, which showed no significant difference in effectiveness, indicating a lack of strong evidence for the benefits of O&M training.
The studies highlighted the need for better-designed randomized controlled trials (RCTs) to evaluate different types of O&M training, as well as the importance of using standardized measurement tools to assess mobility performance and quality of life in individuals with low vision.
Orientation and mobility training for adults with low vision.Virgili, G., Rubin, G.[2021]
A new virtual reality platform was developed to objectively assess functional vision in individuals with low vision, specifically targeting those with central and peripheral vision loss.
The pilot study revealed that participants with low vision performed significantly worse on visual tasks compared to those with normal vision, with the peripheral field loss group taking the longest to complete tasks, highlighting the challenges faced by these individuals in realistic scenarios.
Development of Immersive Virtual Reality Environment for Assessment of Functional Vision in people with Low Vision: A Pilot Study.Gopalakrishnan, S., Samson, CE., Kumar, M., et al.[2022]

Citations

Orientation and mobility training for adults with low vision - PMCOrientation and mobility (O&M) training is provided to people who are visually impaired to help them maintain travel independence.
2.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/20464725/
Orientation and mobility training for adults with low visionBackground: Orientation and mobility (O&M) training is provided to people who are visually impaired to help them maintain travel independence.
Effects and feasibility of a standardised orientation and ...This paper presents the design of a randomised controlled trial aimed to evaluate this standardised O&M-training in using the identification cane in older ...
The effectiveness of orientation and mobility training on ...The results showed significant increases in quality of life and all subscales (physical health, mental health, social relationships, and ...
Orientation and mobility training for adults with low visionOrientation and mobility (O&M) training is provided to people who are visually impaired to help them maintain travel independence.
Virtual Reality-Base Intelligent Orientation and Mobility ...The human subject research is a randomized, controlled training trial that tests the effectiveness of three Virtual Reality-based Intelligent Orientation ...
VR-Based Mobility Training for Low Vision (VR-IOMS Trial)Research shows that virtual reality-based orientation and mobility training can improve street safety for people with low vision, and it appears to be as ...
Individuals with severely impaired vision can learn useful ...This study demonstrated that virtual reality-based orientation and mobility training could be as efficient as real street training in improving street safety.
A virtual reality platform to simulate orientation and mobility ...An Immersive Virtual Reality Training System for Enhancing Orientation and Mobility in Individuals with Visual Impairments. Advanced Intelligent Computing ...
A virtual reality platform to simulate orientation and mobility ...The VR platform simulates orientation and mobility training for the visually impaired, helping trainers and trainees learn new techniques in a safe environment.
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