Enhancing Memory in Mild Cognitive Impairment and Early Stage Alzheimer's Disease

(MEMORI Trial)

Overseen By Research Assistant

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: The Mind Research Network

Must not be taking: Psychotropic medications

Disqualifiers: Psychiatric disorders, Epilepsy, Stroke, others

Compensation: Varies

Number of Visits: 1

Duration: 1 session

98 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial tests a treatment that uses small electrical currents on the head and arm to improve memory in older adults, including those with early signs of Alzheimer's. The goal is to see if this can help enhance brain activity and memory. Previous studies have shown that this method can improve memory, verbal fluency, and mood in patients with Alzheimer's disease.

Will I have to stop taking my current medications?

You may need to stop taking medications with significant psychotropic effects (drugs that affect mood, perception, or behavior) to participate in this trial. The protocol does not specify other medication restrictions.

Research Team

Vincent Clark, PhD

Principal Investigator

University of New Mexico

Eligibility Criteria

Inclusion Criteria

You have someone who can help you remember and report your medical history.

You must be between 50 and 90 years old and have a photo ID that shows your date of birth.

You are required to be right-handed and learned to speak English before the age of seven.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive transcranial Electrical Stimulation (tES) treatment applied to the right temple and left arm for up to 40 minutes

1 session

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including performance accuracy on a complex visual learning and categorization task

Within one hour after treatment

Treatment Details

Interventions

• North Coast Medical Activadose II

Participant Groups

Group I: Full Current tES Experimental Treatment 1 Intervention

TES delivered with the anode over the right temple and cathode on the left arm, at an intensity of up to 4 milliamps, delivered for up to 40 minutes.

Group II: Partial Current tES Placebo Group 1 Intervention

TES delivered with the anode over the right temple and cathode on the left arm, at an intensity of 0.1 milliamp, delivered for up to 40 minutes.

Who Is Running the Clinical Trial?

The Mind Research Network

Lead Sponsor

Trials

27

Recruited

2,300+