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Noninvasive Brain Stimulation

Transcranial Direct Current Stimulation for PTSD

N/A
Waitlist Available
Led By Mascha van 't Wout-Frank, PhD
Research Sponsored by Butler Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up all sub-study experimental procedures will occur online and in one 'visit' and take approximately 60-90 minutes to complete.
Awards & highlights

Study Summary

This trial will investigate whether electrical stimulation can help people with PTSD by improving their safety memory.

Who is the study for?
This trial is for adults aged 18-70 with a primary diagnosis of PTSD, who can communicate in English and have been on stable psychiatric medication or treatment for at least six weeks. It excludes those with moderate/unstable medical conditions, MRI/tDCS contraindications (like metal implants), colorblindness, severe mental health risks like acute suicidal ideation, significant neurological issues, psychotic/bipolar disorders, or substance abuse.Check my eligibility
What is being tested?
The study tests the timing of transcranial direct current stimulation (tDCS) on safety memory in people with PTSD. Participants are divided into three groups: one gets real tDCS during extinction learning and fake during consolidation; another gets fake during extinction and real during consolidation; the third group receives sham stimulation for both phases. There's also an online sub-study on contextual processing.See study design
What are the potential side effects?
While not explicitly stated here, common side effects of tDCS may include mild itching, tingling or burning sensation at the site of application and headache. Serious side effects are rare but could involve skin irritation under electrode sites or mood changes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~all sub-study experimental procedures will occur online and in one 'visit' and take approximately 60-90 minutes to complete.
This trial's timeline: 3 weeks for screening, Varies for treatment, and all sub-study experimental procedures will occur online and in one 'visit' and take approximately 60-90 minutes to complete. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Psychophysiological reactivity
SUB-STUDY: accuracy in contextual processing
Secondary outcome measures
Neural activity

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Sham during extinction learning / Active during consolidationActive Control1 Intervention
Sham tDCS stimulation will be applied during the extinction learning phase. Active tDCS stimulation will be applied during the consolidation phase
Group II: Active during extinction learning / Sham during consolidationActive Control1 Intervention
Active tDCS stimulation will be applied during the extinction learning phase. Sham tDCS stimulation will be applied during the consolidation phase.
Group III: Sham during extinction learning / Sham during consolidationPlacebo Group1 Intervention
Sham tDCS stimulation will be applied during both the extinction learning phase and the consolidation phase.

Find a Location

Who is running the clinical trial?

Butler HospitalLead Sponsor
129 Previous Clinical Trials
15,896 Total Patients Enrolled
National Institute of General Medical Sciences (NIGMS)NIH
268 Previous Clinical Trials
248,296 Total Patients Enrolled
Mascha van 't Wout-Frank, PhDPrincipal InvestigatorBrown University
1 Previous Clinical Trials
20 Total Patients Enrolled

Media Library

transcranial direct current stimulation (Noninvasive Brain Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT04152772 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Sham during extinction learning / Active during consolidation, Sham during extinction learning / Sham during consolidation, Active during extinction learning / Sham during consolidation
Post-Traumatic Stress Disorder Clinical Trial 2023: transcranial direct current stimulation Highlights & Side Effects. Trial Name: NCT04152772 — N/A
transcranial direct current stimulation (Noninvasive Brain Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04152772 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available places in this trial for prospective participants?

"Affirmative. The clinical trial, which was initially made available on November 22nd 2019, is currently recruiting patients according to the information hosted on clinicaltrials.gov. It requires 590 participants from 1 medical centre to participate in this study."

Answered by AI

How many participants are allowed to join this experiment?

"Affirmative. The clinical trial is currently searching for participants, as suggested by the information from clinicaltrials.gov. This medical study was first launched on November 22nd 2019 and recently updated on July 21st 2022; it seeks to enroll 590 people at one location."

Answered by AI

Which patient demographics are allowed to participate in this medical study?

"The criteria for acceptance into this medical trial necessitates that subjects have moral injury and inhabit the ages of 18 to 70. Around 590 patients are being admitted in total."

Answered by AI

Is the inclusion criterion for this experiment limited to subjects aged sixty and below?

"The parameters for patient inclusion in this experiment set the minimum age of participants at 18, and impose a cap on maximum age at 70."

Answered by AI
Recent research and studies
Behavioral NeuroscienceJournal
Is There a Neuroscience-based, Mechanistic Rationale for Transcranial Direct Current Stimulation as an Adjunct Treatment for Posttraumatic Stress Disorder?
Faucher, C. R., R. A. Doherty, N. S. Philip, A. S. M. Harle, J. J. E. Cole, and M. van't Wout-Frank. 2021. “Is There a Neuroscience-based, Mechanistic Rationale for Transcranial Direct Current Stimulation as an Adjunct Treatment for Posttraumatic Stress Disorder?”. Behavioral Neuroscience. American Psychological Association (APA). doi:10.1037/bne0000487.
Behavioral NeuroscienceJournal
Is There a Neuroscience-based, Mechanistic Rationale for Transcranial Direct Current Stimulation as an Adjunct Treatment for Posttraumatic Stress Disorder?
Faucher, C. R., R. A. Doherty, N. S. Philip, A. S. M. Harle, J. J. E. Cole, and M. van't Wout-Frank. 2021. “Is There a Neuroscience-based, Mechanistic Rationale for Transcranial Direct Current Stimulation as an Adjunct Treatment for Posttraumatic Stress Disorder?”. Behavioral Neuroscience. American Psychological Association (APA). doi:10.1037/bne0000487.
Behavioral NeuroscienceJournal
Is There a Neuroscience-based, Mechanistic Rationale for Transcranial Direct Current Stimulation as an Adjunct Treatment for Posttraumatic Stress Disorder?
Faucher, C. R., R. A. Doherty, N. S. Philip, A. S. M. Harle, J. J. E. Cole, and M. van't Wout-Frank. 2021. “Is There a Neuroscience-based, Mechanistic Rationale for Transcranial Direct Current Stimulation as an Adjunct Treatment for Posttraumatic Stress Disorder?”. Behavioral Neuroscience. American Psychological Association (APA). doi:10.1037/bne0000487.
clinicaltrials.govStudy
Effect of tDCS Timing on Safety Memory in PTSD
Mascha Frank 2019. "Effect of tDCS Timing on Safety Memory in PTSD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04152772.
~98 spots leftby Apr 2025
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