Radiofrequency Ablation for Parathyroid Cancer

Overseen By Thinh Vu, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: M.D. Anderson Cancer Center

Must not be taking: Cinacalcet

Disqualifiers: Cardiac arrhythmia, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: Outpatient basis

20 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The study will be an effectiveness study. The study will include enrollment of a total of 20 patients with at least one PC lesion for ultrasound guided RFA to PC recurrence in the neck to assess the effectiveness in reducing patient's hypercalcemia. Patients will have surgically proven PC from prior parathyroidectomy and suspicious PC visible on ultrasound and request for treatment for uncontrolled hypercalcemia (Figure 1).

Who Is on the Research Team?

Thinh Vu, MD

Principal Investigator

UT MD Anderson

Are You a Good Fit for This Trial?

Inclusion Criteria

I am healthy enough for procedures with local anesthesia or sedation.

Patients with distant oligometastasis visible on ultrasound

Selected nodule visible on ultrasound without significant extension posterior to trachea or mediastinal component

Exclusion Criteria

Patients with calcified nodules

My nodule is mostly cystic, with less than 70% solid parts.

Patients with contralateral vocal cord paralysis

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive ultrasound-guided radiofrequency ablation (RFA) for recurrent parathyroid carcinoma

Outpatient basis

Follow-up

Participants are monitored for safety and effectiveness after treatment, including serum calcium level and PTH monitoring

1 year

What Are the Treatments Tested in This Trial?

Interventions

• Radiofrequency Ablation

How Is the Trial Designed?

Group I: Treatment with Ultrasound-guide RFA Experimental Treatment 1 Intervention

Participants treatment will be administered on an outpatient basis.

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials

3,107

Recruited

1,813,000+