Diet Modification for Obesity

(INTERACT Trial)

Overseen By INTERACT Study

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Washington

Must not be taking: Weight-loss, Appetite-altering

Disqualifiers: Diabetes, Multiple sclerosis, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.

Who Is on the Research Team?

Ellen Schur, MD, MS

Principal Investigator

University of Washington

Are You a Good Fit for This Trial?

Inclusion Criteria

I am between 20 and 45 years old.

I am willing to follow strict eating plans for a week each.

Member of the Washington State Twin Registry

Exclusion Criteria

Non-English speaking-or-reading individuals

High levels of vigorous physical activity (>300 min./week)

Pregnancy, menopause, or breastfeeding

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Study 1

Monozygotic twin pairs with differential habitual diet practices undergo measurements including body composition, and MRI measures of hepatic adiposity and neuroinflammation

1 visit

1 visit (in-person)

Study 2

Monozygotic twin pairs are provided an assigned diet for 14 days with 3 in-person study visits including brain MRI, body composition measurements, blood draws, and questionnaires

2 weeks

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Diet modification

How Is the Trial Designed?

Group I: Study 2, A twin study of controlled diet Experimental Treatment 1 Intervention

Monozygotic twin pairs will be provided an assigned diet for 14-days.

Group II: Study 1, A co-twin control study of habitual diet Active Control 1 Intervention

Monozygotic twin pairs with differential habitual diet practices will undergo measurements including body composition, and MRI measures of hepatic adiposity and neuroinflammation.

Who Is Running the Clinical Trial?

University of Washington

Lead Sponsor

Trials

1,858

Recruited

2,023,000+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials

2,513

Recruited

4,366,000+