Resveratrol for Exercise Performance and Recovery

Overseen By Trevor Dufner

Age: 18 - 65

Sex: Male

Trial Phase: Academic

Sponsor: University of Central Florida

Must not be taking: Performance-enhancing drugs, NSAIDs

Disqualifiers: Musculoskeletal injury, Chronic pain, others

Approved in 3 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 14

Duration: 2.5 weeks

20 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial examines how a daily dose of resveratrol, a plant compound found in grapes, affects muscle function and soreness after exercise. Researchers aim to determine if resveratrol aids muscle recovery and reduces damage and stress indicators in individuals who engage in regular strength training. The trial targets healthy men who exercise regularly, specifically those who perform strength training with weights at least three times a week. Participants will take either resveratrol or a placebo for 17 days and report changes in muscle soreness and performance. As an unphased trial, this study provides participants the opportunity to contribute to groundbreaking research on muscle recovery.

Will I have to stop taking my current medications?

The trial requires participants to stop taking any performance-enhancing drugs and nutritional supplements known to improve physical performance for at least 28 days before starting the study. Regular use of prescription or over-the-counter medications that affect performance is also not allowed.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that resveratrol, a natural substance in red grapes, is usually safe for consumption. Studies have found that side effects rarely occur, and small doses are generally safe. For instance, taking 5-10 mg per day is typically fine, with no major negative effects reported at these levels.

Resveratrol is also known for reducing swelling and protecting cells from damage. However, the amount used in this study exceeds the usual daily recommendation. Participants should consider this and consult a healthcare provider if they have any concerns. ^{1 2 3 4 5}

Why do researchers think this study treatment might be promising?

Unlike the standard methods for enhancing exercise performance, which typically involve endurance training, nutritional interventions, or performance-enhancing drugs, resveratrol stands out due to its natural origin and potential health benefits. Resveratrol is a compound found in the skin of red grapes and is believed to have antioxidant properties that may aid in exercise recovery and performance. Researchers are excited about resveratrol because it offers a novel approach by potentially enhancing mitochondrial function and reducing oxidative stress, which could improve endurance and recovery times in athletes. This makes resveratrol a promising alternative to current options that often come with side effects or require significant lifestyle changes.

What evidence suggests that resveratrol might be an effective treatment for exercise performance and recovery?

This trial will compare resveratrol supplementation with a placebo to evaluate its effects on exercise performance and recovery. Research has shown that resveratrol, a natural substance found in foods like red grapes, might improve exercise performance by increasing muscle strength and endurance. Some studies suggest it can boost power in athletes. However, strong evidence to confirm these benefits in people is still lacking. One study found that taking 500 mg of resveratrol daily, along with dieting and exercise, helped reduce liver fat. While these early results are promising, more research is needed to fully understand its impact on muscle recovery and performance. ^{2 3 6 7 8}

Are You a Good Fit for This Trial?

This trial is for young adult males who regularly engage in resistance training. They must be healthy and willing to take a daily supplement or placebo for 17 days, then perform specific squat exercises.

Inclusion Criteria

Recreationally active according to ACSM standards of at least 150 minutes exercise per week

Healthy and ready for physical activity as determined by the PAR-Q+ and MHQ

I am a man aged between 18 and 40.

Exclusion Criteria

Individual does not provide consent to participate in the study

Not currently participating in at least 150 minutes of physical activity per week

I am unable to perform physical exercises.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week

1 visit (in-person)

Treatment

Participants receive once daily supplementation with 500mg VeriSperse® resveratrol or placebo for 17 days

2.5 weeks

13 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Resveratrol

Trial Overview The study tests if taking 500 mg of VeriSperse® resveratrol (VRES) daily improves muscle function, reduces soreness, and affects markers of muscle damage and oxidative stress after intense leg workouts compared to a placebo.

How Is the Trial Designed?

Group I: Resveratrol Supplementation Active Control 1 Intervention

Once daily (immediately upon waking) supplementation with 500mg (2 capsules) VeriSperse® resveratrol (VRES) for 17 days

Group II: Placebo Placebo Group 1 Intervention

Once daily (immediately upon waking) supplementation with 500mg (2 capsules) Placebo (maltodextrin) for 17 days

Resveratrol is already approved in United States, European Union, Canada for the following indications:

Approved in United States as Resveratrol for:

• Dietary supplement for cardiovascular health and antioxidant properties

Approved in European Union as Resveratrol for:

• Dietary supplement for cardiovascular health and antioxidant properties

Approved in Canada as Resveratrol for:

• Dietary supplement for cardiovascular health and antioxidant properties

Who Is Running the Clinical Trial?

University of Central Florida

Lead Sponsor

Trials

101

Recruited

1,191,000+

Gencor Pacific Group

Industry Sponsor

Trials

4

Recruited

300+

Published Research Related to This Trial

Synthetic cis-polymethoxystilbenes, derived from the biologically inactive cis-resveratrol, showed potent anti-cancer effects against metastatic B16 F10 melanoma cells, with an IC50 of less than 10 μM, indicating strong efficacy.

These compounds inhibited cell motility and proliferation more effectively than both cis- and trans-resveratrol, suggesting they could be promising candidates for chemotherapy in treating metastatic melanoma.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells. Morris, VL., Toseef, T., Nazumudeen, FB., et al.[2018]

A study involving 25 healthy individuals found that after moderate consumption of red wine, trans-resveratrol was mostly present in the form of glucuronides in the bloodstream, rather than as free trans-resveratrol, indicating limited bioavailability of the compound itself.

The bioavailability of trans-resveratrol was consistent regardless of the type of meal consumed, suggesting that the health benefits attributed to red wine may be more related to the overall antioxidant content rather than just trans-resveratrol.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Bioavailability of trans-resveratrol from red wine in humans. Vitaglione, P., Sforza, S., Galaverna, G., et al.[2018]

In a clinical trial involving 66 older adults with peripheral artery disease (PAD), resveratrol at a dose of 125 mg/day showed a slight improvement in 6-minute walk distance compared to placebo, but the results were not statistically significant (P=0.07).

The higher dose of 500 mg/day of resveratrol did not improve walking performance and was similar to the placebo group, indicating that resveratrol may not be an effective treatment for enhancing walking ability in older patients with PAD.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial. McDermott, MM., Leeuwenburgh, C., Guralnik, JM., et al.[2019]

Trans-resveratrol is primarily metabolized into two main forms: trans-resveratrol-3-O-glucuronide and trans-resveratrol-3-sulfate, which were found abundantly in rat urine and mouse serum, indicating effective metabolism in the body.

The study found virtually no unconjugated resveratrol in urine or serum samples, suggesting that previous in vitro studies using only unconjugated resveratrol may not accurately reflect its metabolism and effects in living organisms.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Human, rat, and mouse metabolism of resveratrol. Yu, C., Shin, YG., Chow, A., et al.[2019]

Trans-resveratrol (t-RESV), found in grape skins and red wine, shows significant anti-inflammatory and anticarcinogenic properties in various experimental models, highlighting its potential as a therapeutic agent.

The cis isomer of resveratrol (c-RESV) is less studied and not commercially available, leading to a gap in understanding its pharmacological effects compared to the well-researched t-RESV.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Orallo, F.[2022]

A new method was developed to accurately measure resveratrol levels in animal and human samples, showing high specificity and recovery rates (96.8%) with a low detection limit of 50 ng/ml.

The study demonstrated that resveratrol can be effectively incorporated into blood cells and lipoproteins, suggesting its potential role in inhibiting lipoprotein oxidation and platelet activity.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations. Blache, D., Rustan, I., Durand, P., et al.[2019]

Cis-resveratrol significantly reduces collagen-induced platelet aggregation in vitro, with a decrease of 43.5% at a concentration of 1 x 10(-5) M, indicating its potential as an anti-aggregating agent.

Trans-resveratrol also shows anti-aggregating effects but is slightly less effective than cis-resveratrol, suggesting that both isomers should be considered when evaluating resveratrol's overall activity in biological systems.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Antiplatelet activity of cis-resveratrol. Bertelli, AA., Giovannini, L., Bernini, W., et al.[2018]

Trans-resveratrol at a dosage of 2000 mg twice daily was found to be well tolerated in a study of eight healthy subjects, although diarrhea was a common side effect in six participants.

The study revealed that taking trans-resveratrol with a standard breakfast maximizes its absorption, while a high-fat meal significantly reduces its plasma concentration, indicating the importance of meal composition on its pharmacokinetics.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. la Porte, C., Voduc, N., Zhang, G., et al.[2021]

This study analyzed the content of trans- and cis-resveratrol in 18 commercial Serbian wines, revealing that trans-resveratrol was present in all but one sample, with concentrations ranging from 0.11 to 1.69 mg/L.

Cis-resveratrol was found in 12 out of the 18 wines, with levels between 0.12 and 1.49 mg/L, indicating that Serbian wines contain significant amounts of these beneficial compounds, which are associated with various health benefits.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Determination of trans- and cis-resveratrol in Serbian commercial wines. Cvejic, JM., Djekic, SV., Petrovic, AV., et al.[2019]

Red wines contain significantly higher levels of beneficial compounds like resveratrol and piceid, averaging 4.37 mg/liter, compared to only 0.68 mg/liter in white wines, suggesting a stronger protective effect against cardiovascular disease from red wine consumption.

The study analyzed 42 wines from various regions in Japan, confirming that specific grape varieties, such as Pinot noir, Merlot, and Zweigeltrebe, have particularly high resveratrol content, which may contribute to their health benefits.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Contents of resveratrol, piceid, and their isomers in commercially available wines made from grapes cultivated in Japan. Sato, M., Suzuki, Y., Okuda, T., et al.[2019]

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11902109/

Resveratrol and Physical Activity: A Successful Combination ... Some studies suggest that RES supplementation may enhance exercise performance by increasing muscle strength, endurance, and power output. This may be due to ...

2. en.wikipedia.org en.wikipedia.org/wiki/Resveratrol

Resveratrol Although commonly used as a dietary supplement and studied in laboratory models of human diseases, there is no high-quality evidence that resveratrol improves ...

3. bmccomplementmedtherapies.biomedcentral.com bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03381-4

Effects of resveratrol supplementation on bone quality Resveratrol supplementation did not show any significant effect on BMD or serum bone markers with the current evidence.

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC6836070/

Post-Exercise Recovery Following 30-Day ... Background: The purpose of this study was to investigate the effects of 30-day consumption of trans-resveratrol and polyphenol-enriched extracts ...

5. rxlist.com rxlist.com/supplements/resveratrol.htm

Resveratrol: Health Benefits, Side Effects, Uses, Dose & ... However, taking 500 mg of resveratrol daily for 12 weeks while also dieting and exercising reduces fat buildup in the liver and improves liver function in ...

6. pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov/compound/Resveratrol

Resveratrol | C14H12O3 | CID 445154 - PubChem - NIH Resveratrol is a plant polyphenol found in high concentrations in red grapes that has been proposed as a treatment for hyperlipidemia and to prevent fatty liver

7. s3-us-west-2.amazonaws.com s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/001/706/original/resveratrol_508.pdf?1538174757

trans-Resveratrol [501-36-0] Review of Toxicological ... Human Studies: Adverse effects of resveratrol have not been reported; a recommended dosage of 5-10 mg (22-44 µmol) per day was stated to be " ...

8. sciencedirect.com sciencedirect.com/topics/nursing-and-health-professions/resveratrol

Resveratrol - an overview Resveratrol is defined as a compound that may mitigate the decline in aging skeletal muscle through its anti-inflammatory and antioxidant properties, ...