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Combination Therapy

Personalized Combination Drug Therapy for Cancer Stem Cells for Glioblastoma

Q: Are new participants currently being accepted for enrollment in this clinical trial?

<p>Based on the information available on clinicaltrials.gov, this research study is in the process of enrolling volunteers. The trial was first listed on April 1st, 2024 and underwent its most recent revision on April 8th, 2024.</p>

Q: How many participants in total are involved in this particular research endeavor?

<p>Yes, the details on clinicaltrials.gov show that this trial is currently seeking volunteers. The trial was initially published on April 1st, 2024 and was most recently revised on April 8th, 2024. This study aims to enroll a total of 10 participants from one designated site.</p>

Phase < 1

Recruiting

Led By Charles S Cobbs

Research Sponsored by Swedish Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from inclusion in the study until date of death from any cause, assessed up to approximately 36 months

Awards & highlights

Study Summary

This trial aims to treat patients with a type of brain cancer called glioblastoma using personalized drug regimens that have shown to be effective in the lab. Patients will also receive standard radiation and TMZ

Who is the study for?

This trial is for adults over 18 with a recent diagnosis of Glioblastoma (GBM, WHO grade 4) who haven't had cancer treatment before. They should be healthy enough for surgery to remove most of the tumor and have a life expectancy over 6 months. Participants need good blood counts, no HIV or Hepatitis B/C, and must be physically able to handle daily activities.Check my eligibility

What is being tested?

The study tests personalized drug combinations (up to three FDA-approved drugs) tailored using cancer stem cells from each patient's tumor. These are given alongside standard radiation and TMZ chemotherapy treatments for newly diagnosed glioblastoma.See study design

What are the potential side effects?

Side effects depend on the specific drugs used but may include fatigue, nausea, hair loss from chemo/radiation, increased infection risk due to weakened immune system, bleeding issues related to low platelet count, and potential organ damage.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from inclusion in the study until date of death from any cause, assessed up to approximately 36 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from inclusion in the study until date of death from any cause, assessed up to approximately 36 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and from inclusion in the study until date of death from any cause, assessed up to approximately 36 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

determine safety of CSC/HTS-based combination drug therapy

Secondary outcome measures

Efficacy of CSC/HTS-based combination drug therapy

Trial Design

1Treatment groups

Experimental Treatment

Group I: Personalized Combination Drug Therapy for Cancer Stem CellsExperimental Treatment1 Intervention

Administer combinations of up to 3 FDA approved drugs from a panel of compounds selected based on high throughput screening

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Swedish Medical CenterLead Sponsor

53 Previous Clinical Trials

8,284 Total Patients Enrolled

1 Trials studying Glioblastoma

9 Patients Enrolled for Glioblastoma

Charles S CobbsPrincipal InvestigatorIvy Center for Advanced Brain Tumor Treatment

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants currently being accepted for enrollment in this clinical trial?

"Based on the information available on clinicaltrials.gov, this research study is in the process of enrolling volunteers. The trial was first listed on April 1st, 2024 and underwent its most recent revision on April 8th, 2024."

Answered by AI

How many participants in total are involved in this particular research endeavor?

"Yes, the details on clinicaltrials.gov show that this trial is currently seeking volunteers. The trial was initially published on April 1st, 2024 and was most recently revised on April 8th, 2024. This study aims to enroll a total of 10 participants from one designated site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma

2024. "Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05380349.