Hormonal Interventions for Sleep Deprivation
Trial Summary
What is the purpose of this trial?
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.
Research Team
Peter Liu, MD, PhD
Principal Investigator
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Eligibility Criteria
Men aged 22-45 with a BMI of 20-28 kg/m2, stable weight for the last six weeks, and no history of significant health issues like brain injury, endocrine abnormalities, diabetes, or drug/alcohol abuse. Participants must not be smokers or have sleep/circadian disorders and should not have traveled across time zones recently.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Sleep Opportunity
Participants are admitted to the chronobiology laboratory and given 1 night of 10 hours sleep opportunity
Sleep Restriction
Participants undergo 4 nights of 4 hours sleep opportunity with various experimental conditions
Follow-up
Participants are monitored for changes in hormonal levels and cognitive function after sleep restriction
Treatment Details
Interventions
- Corticorelin
- Dexamethasone
- Ganirelix
- Gonadorelin
- Hydrocortisone Injection
- Placebo oral capsule
- Saline Solution
Find a Clinic Near You
Who Is Running the Clinical Trial?
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Lead Sponsor