Vagal Nerve Stimulation + Nicotine Replacement for Smoking Cessation
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to provide preliminary evidence for the efficacy of 12 weeks of vagal nerve stimulation (VNS) and nicotine replacement therapy (NRT) for increasing smoking abstinence rates.
Who Is on the Research Team?
Ryan Hurt, MD, PhD
Principal Investigator
Mayo Clinic
Ivana T Croghan, PhD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive nicotine replacement therapy and vagal nerve stimulation for smoking cessation
Follow-up
Participants are monitored for smoking abstinence and safety after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Nicotine Replacement Therapy
- Vagal Nerve Stimulation
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
This arm will receive nicotine patches (21 mg) for 12 weeks and brief behavioral therapy (through the self-help manual Smoke Free and Living It), as well as the vagal nerve stimulator (VNS) device to use during these 12 weeks while trying to stop smoking. The VNS delivers up to 30 stimulations over 24 hours.
This arm will receive nicotine patches (21 mg) for 12 weeks and brief behavioral therapy (through the self-help manual Smoke Free and Living It).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
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