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Stress Testing Protocol for Coronary Heart Disease

N/A

Recruiting

Led By Michael Nelson, PhD

Research Sponsored by Cedars-Sinai Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 hours

Awards & highlights

Study Summary

This trial is studying microvascular coronary dysfunction, which is abnormalities in small blood vessels/arteries in the heart, in women.

Who is the study for?

This trial is for men and women over 18 who fully understand and agree to the study's procedures. It excludes pregnant women, those unable to consent, with a history of heart/lung/brain diseases, high blood pressure, diabetes, metal implants or claustrophobia (which affects MRI testing), adherence issues, or animal dander allergies.Check my eligibility

What is being tested?

The study tests how different 'stress' activities like handgrip exercises, leg exercises, and altitude simulation affect small blood vessels in the heart using advanced cardiac MRI. It aims to better understand coronary microvascular dysfunction in women with chest pain but no large artery blockages.See study design

What are the potential side effects?

Since this trial involves physical stress tests rather than medication or invasive procedures, side effects may include temporary muscle fatigue or soreness from exercise and discomfort from being in confined spaces during MRI scans.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Diastolic function by MRI

Trial Design

3Treatment groups

Experimental Treatment

Group I: calibrationExperimental Treatment3 Interventions

10 healthy individuals who will help to synchronize our imaging and stress testing maneuvers.

Group II: Women w/microvascular diseaseExperimental Treatment3 Interventions

10 women with microvascular disease

Group III: Normal controlsExperimental Treatment3 Interventions

10 age-matched women with no evidence of microvascular disease

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Cedars-Sinai Medical CenterLead Sponsor

500 Previous Clinical Trials

164,869 Total Patients Enrolled

6 Trials studying Nephrotic Syndrome

667 Patients Enrolled for Nephrotic Syndrome

Michael Nelson, PhDPrincipal InvestigatorCedars-Sinai Medical Center

Media Library

Handgrip Clinical Trial Eligibility Overview. Trial Name: NCT02301663 — N/A

Nephrotic Syndrome Research Study Groups: Women w/microvascular disease, calibration, Normal controls

Nephrotic Syndrome Clinical Trial 2023: Handgrip Highlights & Side Effects. Trial Name: NCT02301663 — N/A

Handgrip 2023 Treatment Timeline for Medical Study. Trial Name: NCT02301663 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients still being recruited for this research study?

"According to the clinicaltrials.gov website, this research is currently looking for 30 individuals at 1 location. The listing was created on November 1st, 2014 and updated on August 17th, 2021."

Answered by AI

Does this research allow for elderly participation?

"Eligibility criteria for this clinical trial include being between 18-60 years old."

Answered by AI

How do I qualify to participate in this clinical research?

"Up to 30 patients that are male or female, aged 18 or older may participate in this trial if they have nephrotic syndrome and meet the other listed requirements. These include: being willing and able to undergo study procedures and fully comprehending the risks involved as well as signing a consent form."

Answered by AI

How many people are currently signed up for this experiment?

"That is correct. The clinical trial was first posted on 11/1/2014, and the most recent update was on 8/17/2021. According to the information available on clinicaltrials.gov, they are recruiting 30 participants from 1 location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease

Noel Bairey Merz 2014. "Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02301663.

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