AGE Serum for Loose Skin

Overseen By Andrea Paccheco

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Goldman, Butterwick, Fitzpatrick and Groff

Must be taking: GLP-1 agonists

Must not be taking: Immunosuppressives, Anticoagulants

Disqualifiers: Pregnancy, Menopause, Autoimmune diseases, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 12 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the safety and effectiveness of a new topical serum, called AGE serum, designed to improve visible signs of aging such as fine lines, wrinkles, and sagging skin on the face and neck. It targets individuals currently using GLP-1 agonist medications (such as Ozempic, Rybelsus, or Wegovy) for weight loss who have mild to moderate facial aging signs. Participants should not be experiencing menopause and must not have any active skin conditions or recent cosmetic treatments in the target areas. Those who have used a GLP-1 agonist for at least six months and notice signs of aging on their face may find this trial suitable. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on aging treatments.

Will I have to stop taking my current medications?

The trial requires participants to continue their current GLP-1 agonist medication, like Ozempic, Rybelsus, or Wegovy, at a stable dose. The protocol does not specify if you need to stop other medications, so it's best to discuss with the study team.

Is there any evidence suggesting that AGE Serum is likely to be safe for humans?

Research has shown that AGE Serum is generally safe to use. In one study comparing two anti-aging serums, participants using AGE Serum reported no serious side effects. Some experienced mild reactions like skin redness or irritation, but these were rare and resolved quickly.

Another study on a similar anti-aging product found it improved skin hydration and texture without causing significant problems. Although specific data on AGE Serum is limited, these results suggest it is safe for most people. However, consulting a healthcare provider before starting any new treatment is always wise. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike the standard treatments for loose skin, which often involve surgical procedures or laser therapies, AGE Serum offers a non-invasive alternative. This serum is unique because it likely contains advanced glycation end-products (AGEs) or targets them, which are associated with skin aging and loss of elasticity. Researchers are excited because AGE Serum could potentially improve skin firmness and texture without the need for more aggressive treatments, offering a simpler and potentially safer option for those looking to enhance their skin's appearance.

What evidence suggests that AGE Serum might be an effective treatment for visible signs of aging?

Studies have shown that the AGE Serum, which participants in this trial will receive, can effectively firm and tighten skin, particularly on the face and neck. In real-world examples, this serum improved skin texture and reduced fine lines and wrinkles. Research indicates that by week 24, participants using a similar serum experienced significant skin improvements. This suggests that the AGE Serum could help with visible signs of aging, such as sagging and reduced glow. The serum works by addressing the natural decline of collagen and elastin, proteins that keep skin firm and stretchy. ^{1 2 3 6 7}

Are You a Good Fit for This Trial?

This trial is for non-menopausal men and women who are using GLP-1 agonist therapy for weight loss. Participants should be interested in improving signs of aging on their face and neck, such as wrinkles or sagging skin.

Inclusion Criteria

Presence of mild to moderate signs of facial aging based on modified Griffith scale

Fitzpatrick skin types I-IV

Must be willing to sign a photography release and ICF, and complete the entire course of the study

Exclusion Criteria

History of autoimmune connective tissue disease

Significant history or current evidence of a medical, psychological or other disorder that, in the investigator's opinion, would preclude enrollment into the study

History of specific medical conditions or sensitivities

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants apply AGE Serum to the full face and neck twice daily

12 weeks

2 visits (in-person) at Week 6 and Week 12

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• AGE Serum

Trial Overview The trial is testing the safety and effectiveness of a topical serum called AGE Serum. It aims to see if this serum can improve the appearance of aging on the full face and neck when used by individuals undergoing GLP-1 agonist therapy.

How Is the Trial Designed?

Group I: AGE Product Experimental Treatment 1 Intervention

Enrolled subjects will received AGE Serum.

Who Is Running the Clinical Trial?

Goldman, Butterwick, Fitzpatrick and Groff

Lead Sponsor

Trials

32

Recruited

660+

L'Oreal

Industry Sponsor

Trials

22

Recruited

11,100+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12291436/

Real World Case Series: A.G.E. Interrupter Ultra Serum The A.G.E. Interrupter Ultra serum offers multiple benefits, notably firming and tightening skin in four key areas across the face and neck.

2. withpower.com withpower.com/trial/phase-laxity-skin-9-2025-8082a

AGE Serum for Loose Skin · Info for Participants The primary objective is to evaluate the safety and efficacy of a topical serum (AGE serum) in improving visible signs of aging (e.g., fine lines, wrinkles, ...

3. trial.medpath.com trial.medpath.com/clinical-trial/8f14c6dfe92ee0aa/nct07216352-age-serum-safety-efficacy-glp1-agonists

Evaluate the Safety and Efficacy of a Topical Serum (AGE ... The primary objective is to evaluate the safety and efficacy of a topical serum (AGE serum) in improving visible signs of aging (e.g., ...

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10667605/

A randomized, double‐blind, controlled study evaluating ... By week 24, the participants that used the facial serum with Liposomal Blend showed significant improvements of the following skin ...

5. latrenta.com latrenta.com/blog/skin-tightening-without-surgery-the-most-effective-options-in-2025-supporting-statistics-on-treatment-efficacy

Skin Tightening Without Surgery: The Most Effective ... With aging, the natural decline of collagen and elastin leads to skin laxity, prompting many to seek effective skin tightening without surgery.

6. app.trialscreen.org app.trialscreen.org/trials/evaluate-safety-efficacy-topical-serum-age-improving-visible-signs-aging-trial-nct07216352

Evaluate the Safety and Efficacy of a Topical Serum (AGE ... Participants may experience improvement in their skin's appearance including reduced fine lines and wrinkles, better skin texture, and increased ...

7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC7442306/

Safety and Efficacy of a Novel Antiaging Skin Care ... This novel, topical antiaging skin care regimen demonstrated improvements in facial skin hydration, skin barrier function, and skin lift over a 12-week period.