Therapies for PTSD
(ADAPT-PTSD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how different therapy strategies can better support veterans with PTSD, especially those not benefiting from their initial treatment or struggling with therapy homework. It examines whether switching to therapies like Cognitive Processing Therapy (CPT) or Prolonged Exposure (PE), or using modular versions of these therapies, can improve outcomes. Participants receive text message prompts to assist with homework between sessions. Veterans with PTSD who own a mobile device and are eligible for PE and CPT at a participating clinic might be suitable for this study. As an unphased trial, this study offers veterans the opportunity to explore innovative therapy strategies that could enhance their treatment experience.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that both Cognitive Processing Therapy (CPT) and Prolonged Exposure (PE) therapy have been thoroughly studied for treating post-traumatic stress disorder (PTSD). Studies indicate that CPT is generally well-tolerated, with only 14.7% of patients experiencing some side effects, which is low compared to other treatments. Most people notice improvements in PTSD and depression symptoms.
Prolonged Exposure therapy has also significantly reduced PTSD symptoms. Many studies demonstrate that PE is effective, with success rates between 65% and 80%. This means that most people find it helpful and safe.
Both therapies have been adapted into flexible forms, allowing for more personalized treatment plans. These adaptations have also improved PTSD symptoms without increasing side effects.
Since these therapies are well-researched and commonly used in clinical practice, they are considered safe with few side effects for most people. However, as with any treatment, individual experiences may vary. It's always important to consult a healthcare provider to ensure it's the right fit.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores how different therapy approaches can be personalized for treating PTSD more effectively. Unlike traditional treatments that stick to a single method, this trial looks at how switching or modifying treatments, like transitioning from Cognitive Processing Therapy (CPT) to Prolonged Exposure (PE) therapy or using modular versions of these therapies, might benefit patients who don't initially respond. By adapting treatments based on early responses, the trial aims to find out if tailored therapy strategies lead to better outcomes and more flexibility in managing PTSD.
What evidence suggests that this trial's treatments could be effective for PTSD?
Research has shown that Cognitive Processing Therapy (CPT), one of the therapies studied in this trial, effectively treats PTSD by reducing symptoms and depression over time. Participants may receive either CPT or Prolonged Exposure (PE) therapy, another treatment option in this trial. Studies have found PE to be effective, with success rates between 65% and 80%. The trial also includes flexible versions of CPT and PE, tailored to individual needs, which lead to significant improvements in PTSD and depression. Additionally, Step Down Treatment, involving a transition to less intense therapy, is evaluated to help maintain progress and continue improvement after initial treatment. Each of these therapies has been tested in various settings and has shown positive results in reducing PTSD symptoms.12678
Who Is on the Research Team?
Stefanie LoSavio, PhD
Principal Investigator
The University of Texas Health Science Center at San Antonio
Rebecca Sripada, PhD
Principal Investigator
VA Ann Arbor-506
Are You a Good Fit for This Trial?
This trial is for veterans struggling with Post-Traumatic Stress Disorder (PTSD) who haven't seen improvement from their initial treatment or have difficulty completing homework between therapy sessions. Specific eligibility details are not provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo multiple, sequential randomizations to both therapist-delivered and digital interventions to optimize PTSD treatment response
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cognitive Processing Therapy (CPT)
- Digital Interventions
- Modular Cognitive Processing Therapy
- Modular Prolonged Exposure Therapy
- Prolonged Exposure (PE)
- Step Down Treatment
Trial Overview
The ADAPT-PTSD trial is testing various PTSD treatments, including Modular Cognitive Processing Therapy and Prolonged Exposure, both in traditional and digital formats. It also explores the effectiveness of text message prompts to enhance homework completion.
How Is the Trial Designed?
8
Treatment groups
Active Control
Early NON-RESPONDERS to CPT will transition to MODULAR CPT
Early RESPONDERS to CPT will CONTINUE in their CPT treatment
Early NON-RESPONDERS to PE will SWITCH to CPT
Early NON-RESPONDERS to PE will transition to MODULAR PE
Early RESPONDERS to CPT will STEP DOWN to self-managed CPT
Early NON-RESPONDERS to CPT will SWITCH to PE
Early RESPONDERS to PE will STEP DOWN to self-managed PE
Early RESPONDERS will CONTINUE in their PE treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center at San Antonio
Lead Sponsor
United States Department of Defense
Collaborator
Citations
A meta-analytic review of cognitive processing therapy for ...
These meta-analytic findings indicate that CPT is an effective PTSD treatment with lasting benefits across a range of outcomes.
Effectiveness of Cognitive Processing Therapy for PTSD in ...
This study provides promising data on the outcomes associated with a modified CPT protocol for treating PTSD in a high need but under-treated SMI population.
Cognitive Processing Therapy for Posttraumatic Stress ...
The CPT-TAU group maintained improvements in all outcomes from 17 to 34 weeks. Sensitivity analyses controlling for the types of traumatic ...
Cognitive Processing Therapy for PTSD
Participants in the active treatment conditions (both CPT and PE) demonstrated significant improvement in PTSD and depression over the course of treatment as ...
Long-Term Outcomes of Cognitive–Behavioral Treatments ...
CPT and PE resulted in lasting changes in PTSD and related symptoms over an extended period of time for female rape victims with extensive histories of trauma.
Clinician Concerns About Cognitive Processing Therapy
A secondary analysis of randomized clinical trial data showed that 14.7% of patients receiving CPT and 28.6% of clients receiving CPT with a written trauma ...
Cognitive Processing Therapy for Posttraumatic Stress ...
Cognitive processing therapy (CPT) is an evidence-based treatment for posttraumatic stress disorder (PTSD). However, there is little evidence on ...
NCT04230668 | Cognitive Processing Therapy (CPT) for ...
A pilot effectiveness trial of cognitive processing therapy augmented with suicide risk management for individuals with comorbid PTSD and BPD conditions.
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