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Polyphenol

Curcumin for Brain Health Safety & Bioavailability Study

Phase 1 & 2

Recruiting

Led By Chwan-Li (Leslie) Shen, PhD

Research Sponsored by Texas Tech University Health Sciences Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after 2 weeks

Awards & highlights

Study Summary

This trial tests if curcumin can safely pass from the blood to the brain, and if it affects gut bacteria.

Who is the study for?

This trial is for people aged 40-89 with amyloid beta deposits in their retina, without liver or kidney diseases. It's not for pregnant/breastfeeding women, those with certain eye diseases, recent antibiotic use, or allergies to black pepper and turmeric.Check my eligibility

What is being tested?

The study tests how two different doses of curcumin supplements affect the brain and gut over two weeks—whether they can cross into the brain and bind to specific proteins, as well as change gut bacteria.See study design

What are the potential side effects?

Potential side effects are not detailed but monitoring safety suggests watching for any adverse reactions due to curcumin intake which could include digestive discomfort or allergic responses.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after 2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and after 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Retinal imaging- amyloid fluorescent intensity

Retinal imaging-amyloid fluorescent deposit number

Retinal imaging-amyloid fluorescent intensity

+1 more

Secondary outcome measures

Bioavailability- curcumin concentrations in plasma

Bioavailability-curcumin concentrations in plasma

Bioavailability-curcumin concentrations in red blood cells

+5 more

Trial Design

2Treatment groups

Active Control

Group I: High curcumin groupActive Control1 Intervention

Group II: Low curcumin groupActive Control1 Intervention

Do I qualify?Apply below to find out

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Texas Tech University Health Sciences CenterLead Sponsor

104 Previous Clinical Trials

10,714 Total Patients Enrolled

Chwan-Li (Leslie) Shen, PhDPrincipal InvestigatorTexas Tech University Health Sciences Center

2 Previous Clinical Trials

266 Total Patients Enrolled

Media Library

Curcumin (Polyphenol) Clinical Trial Eligibility Overview. Trial Name: NCT05774704 — Phase 1 & 2

Gut Microbiome Research Study Groups: High curcumin group, Low curcumin group

Gut Microbiome Clinical Trial 2023: Curcumin Highlights & Side Effects. Trial Name: NCT05774704 — Phase 1 & 2

Curcumin (Polyphenol) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05774704 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age limit for enrollment in this trial restricted to those under 30?

"This study is accepting applicants in the range of 40 - 89 years old."

Answered by AI

Who can qualify to join this medical test?

"To be eligible for participation, candidates must have bioavailability and fall in the 40-89 year old age range. There are a total of 60 spots available for this trial."

Answered by AI

What are the fundamental aims of this research endeavor?

"This trial has been designed to evaluate the retinal imaging-amyloid fluorescent deposit number over a baseline period. Subsequently, secondary objectives are set in place to measure curcumin concentrations in both plasma and red blood cells as well as conduct serum AST assessments for liver function analysis."

Answered by AI

Are the enrollment criteria for this experiment still open?

"As per the clinicaltrials.gov website, this medical trial is not currently enrolling patients. The study was initially posted on April 1st 2023 and had its latest update March 15th 2023. Although the current research does not require new participants, there are 34 other trials that do accept subjects at present."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Curcumin and Retinal Study

2023. "Curcumin and Retinal Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05774704.