VAMP™ ADVANCED and Microneedling for Cosmetic Skin Health

Overseen By Laura Raco

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: Erevna Innovations Inc.

Must not be taking: Immunosuppressants, Corticosteroids, Chemotherapy, others

Disqualifiers: Allergies, Autoimmune, Cancer, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 6

Duration: 8 weeks for Group A, 12 weeks for Group B

30 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new skin treatment to improve skin quality, focusing on hydration, elasticity, and radiance. It uses a multivitamin serum with polynucleotides (small DNA fragments) from fish, which have been linked to skin regeneration and anti-inflammation. Participants will undergo microneedling—a procedure using tiny needles to rejuvenate the skin—followed by the application of this serum, known as VAMP™ ADVANCED. Individuals with stable skincare routines seeking to enhance their facial skin appearance might be a good fit. As a Phase 4 trial, this research involves an FDA-approved treatment, aiming to understand its benefits for more patients.

Do I have to stop taking my current medications for the trial?

You may need to stop certain medications before joining the trial. Specifically, you should not use topical corticosteroids, retinoids, or depigmenting agents in the treatment area within 4 weeks before the trial. Also, avoid immunosuppressive therapy, systemic corticosteroids, or chemotherapy within 3 months before the trial. If you take medications that affect bleeding, like anticoagulants or NSAIDs, you should stop them 14 days before the trial.

What is the safety track record for VAMP™ ADVANCED?

Research has shown that VAMP™ ADVANCED, a multivitamin serum, contains ingredients such as polynucleotides, amino acids, and vitamins. These components are known to aid in healing and reducing inflammation. PDRN, a key ingredient derived from fish, has been used to heal wounds and improve skin elasticity and smoothness.

The serum aims to enhance skin moisture, flexibility, and glow. While early research suggests potential benefits, further studies are needed to confirm its safety and effectiveness. VAMP™ ADVANCED is currently being tested in a later stage of clinical trials, indicating it has likely been found safe in earlier tests. This suggests the serum is likely well-tolerated, though participants might still experience mild side effects, which is common with skin treatments. ^{1 2 3 4 5}

Why are researchers enthusiastic about this study treatment?

Researchers are excited about VAMP™ ADVANCED for cosmetic skin health because it combines microneedling with a multivitamin serum application, potentially enhancing skin rejuvenation better than standard treatments like topical retinoids or hyaluronic acid serums alone. Unlike other treatments, VAMP™ ADVANCED leverages microneedling to create tiny channels in the skin, allowing the multivitamin serum to penetrate more deeply and work more effectively. This combination is believed to boost collagen production and improve skin texture and tone, offering a unique approach to skin health that could yield impressive results.

What evidence suggests that VAMP™ ADVANCED might be an effective treatment for cosmetic skin health?

In this trial, participants will receive treatments involving VAMP™ ADVANCED combined with microneedling. Studies have shown that PDRN, a key ingredient in VAMP™ ADVANCED, improves skin moisture, color, and strength. Derived from fish DNA, this ingredient helps repair and reduce inflammation. It aids in healing wounds, improving scars, and refreshing the skin. When combined with microneedling, VAMP™ ADVANCED delivers active ingredients deep into the skin, enhancing its flexibility and glow. Early clinical data showed noticeable improvements after just one session, although more research is needed to confirm long-term benefits. Participants in Group A will receive treatments every two weeks, while those in Group B will receive treatments every four weeks. ^{1 2 5 6 7}

Who Is on the Research Team?

Andreas Nikolis, MD, PhD

Principal Investigator

Erevna Innovations Inc.

Are You a Good Fit for This Trial?

This trial is for individuals seeking cosmetic improvement in skin quality. Participants should be interested in a non-invasive treatment involving microneedling and topical serum application to enhance skin hydration, elasticity, and radiance.

Inclusion Criteria

I have not changed my skincare or lifestyle habits in the last 4 weeks.

I want to improve my skin quality.

If the participant is a female of childbearing potential, she agrees to use an acceptable form of effective birth control for the duration of the study and is willing to take a urine pregnancy test (UPT) at Baseline and prior to receiving any study treatment

Exclusion Criteria

Tattoos, piercings, or skin bleaching agents in the treatment area that may interfere with assessments, as judged by the Investigator

Known allergy or intolerance to topical anesthetics or lidocaine

Current pregnancy, positive urine pregnancy test at screening, breastfeeding, or intent to become pregnant during the study

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Initial Treatment

Participants undergo an initial microneedling session followed by a topical application of standardized, non-crosslinked hyaluronic acid

1 session

1 visit (in-person)

Treatment

Participants receive three treatments of microneedling immediately followed by topical application of VAMP™ ADVANCED Topical Multivitamin Serum

8 weeks for Group A, 12 weeks for Group B

4 visits (in-person) for Group A, 4 visits (in-person) for Group B

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks for Group A, 4 weeks for Group B

1 visit (in-person) for Group A, 1 visit (in-person) for Group B

What Are the Treatments Tested in This Trial?

Interventions

• VAMP(TM) ADVANCED

Trial Overview The study tests the effects of VAMP™ ADVANCED Topical Multivitamin Serum applied after microneedling. The serum contains PDRN from fish sources and aims to rejuvenate the skin by improving its texture and reducing fine lines.

How Is the Trial Designed?

Group I: Group A - biweekly treatment schedule Active Control 1 Intervention

Participants in this group will undergo an initial microneedeling session followed by a topical application of standardized, non-crosslinked hyaluronic acid. Following this initial treatment participants in Group A will receive three treatments of microneedeling immediately followed by topical application of VAMP™ ADVANCED Topical Multivitamin Serum every two (2) weeks

Group II: Group B - month treatment schedule Active Control 1 Intervention

Participants in this group will undergo an initial microneedeling session followed by a topical application of standardized, non-crosslinked hyaluronic acid. Following this initial treatment participants in Group B will receive three treatments of microneedeling immediately followed by topical application of VAMP™ ADVANCED Topical Multivitamin Serum every four (4) weeks

Who Is Running the Clinical Trial?

Erevna Innovations Inc.

Lead Sponsor

Trials

13

Recruited

340+

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT07210190

VAMP(TM) ADVANCED and Microneedling for Skin Heath While early data suggest potential benefits, clinical research is still limited, and further study is needed. Official Title. A Prospective ...

2. medicaldevicenavigator.com medicaldevicenavigator.com/microneedling_innovation_vamp_advanced_serum_trial_skin_health/

VAMP™ ADVANCED Serum Trial Commences for Skin Health The study investigates the combined use of a microneedling device and the VAMP™ ADVANCED Topical Multivitamin Serum in improving skin health.

3. nuveau.co nuveau.co/microneedling-with-vamp-vitamins-amino-acids-minerals-and-pdrn-the-next-level-skin-rejuvenation-treatment/

Microneedling with VAMP (Vitamins, Amino Acids, Minerals ... In recent clinical data, PDRN treatments showed a noticeable improvement in skin hydration, tone, and resilience after just one session. What Are the Benefits?

4. hushla.net hushla.net/the-vamp-facial-treatment-a-revolutionary-approach-to-skin-rejuvenation/

The VAMP facial treatment: A revolutionary approach to ... The VAMP facial treatment is an advanced skincare procedure that utilizes microneedling technology to deliver potent bioactive ingredients deep into the skin.

5. elpasoplasticsurgery.com elpasoplasticsurgery.com/blog/why-the-vamp-facial-is-the-hottest-skin-treatment-of-2025/

Why the VAMP Facial Is the Hottest Skin Treatment of 2025 Despite its unusual name, the VAMP facial has gained popularity due to its natural approach to skin rejuvenation and impressive results.

6. vampaesthetics.com vampaesthetics.com/

VAMP™ Aesthetics Vamp™ is a bio-revilatizing solution enriched with a powerful blend of vitamins, amino acids, and materials for your skin's rejuvenation and regeneration.

7. eurobeauty.ca eurobeauty.ca/skin-care/vamp/vamp-multi-vitamin-serum-detail

VAMP Multi-Vitamin Serum VAMP helps to improve skin tonicity, tighten pores and smooth wrinkles. It also contributes to restoring skin's glow, hydration and improve skin texture post- ...