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Blood Transfusion Strategies for Heart Attack Patients (TOP Trial)
TOP Trial Summary
This trial will compare two transfusion strategies in order to see which is associated with better outcomes in high-risk surgical patients.
TOP Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTOP Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.TOP Trial Design
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Who is running the clinical trial?
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- I am a veteran with a genetic bleeding disorder.You had a bad reaction to receiving blood before, like getting a fever, rash, or having your red blood cells break down.You are already taking part in another study that looks at how blood transfusions affect health.I am currently pregnant.I have had surgery related to artery disease or for major organ removal.I am a veteran with a genetic blood disorder like Thalassemia or Sickle cell disease.I am unwilling or unable to follow the study protocol due to personal beliefs.I am eligible for the study no matter my blood hemoglobin levels or if I've had blood transfusions.I have not tested positive for COVID-19 during screening or have fully recovered if I did.I am over 18 and my hemoglobin level was below 10gm/dl after surgery.I have been in a critical heart condition for more than 48 hours after a procedure.I have not tested positive for COVID-19, or if I have, I am fully recovered.I am a veteran who has had a stroke, heart disease, or artery disease and need surgery.
- Group 1: Restrictive
- Group 2: Liberal
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are participants still being accepted for this experiment?
"As indicated on clinicaltrials.gov, applications for this medical study are now open. The original posting was registered on February 5th 2018, and the most recent update was done March 4th 2022."
In what geographic regions is this clinical trial taking place?
"Presently, this trial is searching for candidates from 14 different locations. These sites are situated in Houston, Pittsburgh and Minneapolis as well as other cities scattered across the country. To make participating more convenient, you should select a site closest to your residence to reduce travel requirements."
How many individuals have registered for this medical trial?
"To initiate this research project, 3070 eligible volunteers are required. Those wishing to take part can sign up at the Michael E. DeBakey VA Medical Center in Houston, Texas and the VA Pittsburgh Healthcare System University Drive Division in Pennsylvania's largest city."
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