APG-115 for Prolymphocytic Leukemia

Phase-Based Progress Estimates
City of Hope, Duarte, CAProlymphocytic LeukemiaAPG-115 - Drug
All Sexes
What conditions do you have?

Study Summary

This trial is testing a new cancer drug, APG-115, to see if it is safe and effective at treating T-PLL. The study will enroll 24-36 patients.

Eligible Conditions
  • T-Cell Prolymphocytic Leukemia

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: 28 days

28 days
Maximum tolerated dose of APG-115
Maximum tolerated dose of APG-115+APG-2575

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Similar Trials

Trial Design

2 Treatment Groups

APG-115 monotherapy
1 of 2
APG-115 + APG-2575 combination
1 of 2

Experimental Treatment

36 Total Participants · 2 Treatment Groups

Primary Treatment: APG-115 · No Placebo Group · Phase 2

APG-115 monotherapy
Experimental Group · 1 Intervention: APG-115 · Intervention Types: Drug
APG-115 + APG-2575 combinationExperimental Group · 2 Interventions: APG-2575, APG-115 · Intervention Types: Drug, Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 1

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 28 days

Who is running the clinical trial?

Ascentage Pharma Group Inc.Lead Sponsor
42 Previous Clinical Trials
3,131 Total Patients Enrolled
Yifan Zhai, MD, PhDStudy ChairAscentage Pharma Group Inc.
17 Previous Clinical Trials
1,235 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 13 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a type of leukemia called T-PLL that has come back or not responded to previous treatment, and you have already received at least one kind of therapy.

Frequently Asked Questions

Does the APG-115 drug have governmental approval for use?

"While there is some data suggesting that APG-115 is safe, it only received a 2 because there is no evidence yet that the medication is effective." - Anonymous Online Contributor

Unverified Answer

Are new patients still being sought for this experiment?

"The data on clinicaltrials.gov does indicate that this clinical trial is currently recruiting participants. The trial was initially posted on 7/12/2021 and was most recently edited on 7/8/2022. The clinical trial is enrolling 36 patients across 3 locations." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.