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tFUS Modulation of Brain Activity in Healthy Subjects

N/A

Recruiting

Research Sponsored by Medical University of South Carolina

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 20 minutes

Awards & highlights

Study Summary

This trial will test if ultrasound can modify the connection between two key brain regions and potentially help develop treatments for mental health conditions.

Who is the study for?

This trial is for healthy individuals aged 18-65 who can consent to participate. It's not suitable for those with frequent headaches, untreated medical conditions, heart issues, seizure history, severe brain injuries, psychosis or mania, metal implants in head/heart/neck, MRI contraindications, brain surgery history, heavy alcohol/substance use or pregnant/lactating women.Check my eligibility

What is being tested?

The study tests if transcranial focused ultrasound (tFUS) affects the connection between two brain areas—the Nucleus Accumbens and Prefrontal Cortex—in healthy people. Participants will receive tFUS inside an MRI scanner to see if it changes their resting state brain connectivity.See study design

What are the potential side effects?

As this is a pilot trial involving healthy subjects and non-invasive technology like tFUS within an MRI environment; specific side effects are not detailed but may include discomfort from the ultrasound application or unforeseen reactions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 20 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~20 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 20 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Resting State Functional Connectivity

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active tFUSExperimental Treatment1 Intervention

tFUS will be administered within the MRI scanner. Participants receive two, 10-min sessions of active tFUS spread 10 min apart targeting the nucleus accumbens.

Group II: Sham tFUSPlacebo Group1 Intervention

The sham sessions will include a transducer that is connected in a similar fashion to that of active tFUS, however the cable will not be plugged into the system, thus no ultrasound will be delivered to the participant. Participants will not know or be told whether they are receiving active- or sham- tFUS.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor

933 Previous Clinical Trials

7,394,626 Total Patients Enrolled

Media Library

Active tFUS Clinical Trial Eligibility Overview. Trial Name: NCT05986019 — N/A

Healthy Subjects Research Study Groups: Active tFUS, Sham tFUS

Healthy Subjects Clinical Trial 2023: Active tFUS Highlights & Side Effects. Trial Name: NCT05986019 — N/A

Active tFUS 2023 Treatment Timeline for Medical Study. Trial Name: NCT05986019 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do I meet the requirements to participate in this research?

"To be considered for the trial, applicants must present as healthy and fall between 18 to 65 years of age. This clinical study is in search of 10 individuals that meet these criteria."

Answered by AI

Does this clinical trial accept individuals aged 50 and over?

"The criteria for this medical investigation necessitate that applicants must be between 18 and 65 years of age. For those under the legal limit or above senior citizen status, there are 54 trials and 384 studies respectively."

Answered by AI

What is the cap on the number of participants in this clinical trial?

"Affirmative, the information found on clinicaltrials.gov indicates that this trial is currently enrolling participants. It was initially posted on July 25th 2023 and updated as recently as August 9th of the same year. This study requires 10 patients to be recruited from 1 centre."

Answered by AI

Are there any vacancies available to join this clinical experiment?

"Indeed, according to the information available on clinicaltrials.gov this medical experiment is currently recruiting participants. It was first posted on July 25th 2023 and latest updated on August 9th 2023 with a target of 10 patients for one site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Transcranial Focused Ultrasound (tFUS) Modulation of Reward Network

Bashar Badran 2023. "Transcranial Focused Ultrasound (tFUS) Modulation of Reward Network". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05986019.