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Fasting + Exercise for NAFLD

Q: Does the age restriction for this medical experiment extend to persons below 30?

<p>In order to be accepted into this clinical trial, participants must meet the age-based requirements; they must be at least 18 years old and not over 65.</p>

N/A

Waitlist Available

Led By Krista Varady, PhD

Research Sponsored by University of Illinois at Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age between 18 to 65 years old

BMI between 30.0 and 49.9 kg/m2

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from week 1 to week 12

Awards & highlights

Study Summary

This trial will show that a combination of fasting and exercise can effectively treat non-alcoholic fatty liver disease, a condition related to obesity and diabetes.

Who is the study for?

This trial is for adults aged 18-65 with obesity (BMI between 30.0 and 59.9) who are sedentary and have non-alcoholic fatty liver disease confirmed by MRI, but not diabetes or other serious health conditions like heart, lung, or kidney diseases. Smokers and those on certain medications affecting the liver or weight are excluded.Check my eligibility

What is being tested?

The study tests if alternate day fasting combined with exercise can be an effective treatment for NAFLD in obese individuals. It aims to see if this lifestyle change improves liver health without medication.See study design

What are the potential side effects?

Potential side effects may include hunger, fatigue, dizziness during fasting days; muscle soreness from new exercise routines; possible changes in mood or sleep patterns due to diet alteration.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 65 years old.

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My BMI is between 30.0 and 49.9.

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My BMI is between 30.0 and 59.9.

Select...

I am between 18 and 65 years old.

Select...

My BMI is between 30.0 and 59.9.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from week 1 to week 12

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from week 1 to week 12

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from week 1 to week 12 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in hepatic steatosis

Secondary outcome measures

Change in Alanine Aminotransferase (ALT)

Change in Aspartate Aminotransferase (AST)

Change in HbA1c

+19 more

Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: ExerciseExperimental Treatment1 Intervention

These participants will participate in a supervised aerobic exercise program 5 times per week, 40-60 min per session, 60-85% HRmax.

Group II: Combination alternate day fasting plus exerciseExperimental Treatment2 Interventions

These participants will consume 600 kcal on the "fast day" and eat ad libitum at home on alternating "feed days". They will also participate in a supervised aerobic exercise program 5 times per week, 40-60 min per session, 60-85% HRmax.

Group III: Alternate day fastingExperimental Treatment1 Intervention

These participants will consume 600 kcal on the "fast day" and eat ad libitum at home on alternating "feed days".

Group IV: ControlActive Control1 Intervention

Controls will be instructed to maintain their weight throughout the trial, and not to change eating or physical activity habits.

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor

607 Previous Clinical Trials

1,559,276 Total Patients Enrolled

1 Trials studying Non-alcoholic Fatty Liver Disease

12 Patients Enrolled for Non-alcoholic Fatty Liver Disease

Krista Varady, PhDPrincipal InvestigatorUniversity of Illinois Chicago

5 Previous Clinical Trials

581 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the recruitment period still open for this experiment?

"This experiment is no longer recruiting, having been initially posted on September 1st 2019 and last modified nearly three years later. However, a plethora of other clinical trials are actively seeking participants at this moment in time — 1436 to be exact."

Answered by AI

Is there any way I can participate in this research endeavor?

"This research trial is currently enrolling 80 individuals aged 18-65 who are considered to be obese, with a BMI of 30.0 to 49.9 kg/m2 and minimal activity (<20 minutes 2 times per week for 3 months prior to the study)."

Answered by AI

Does the age restriction for this medical experiment extend to persons below 30?

"In order to be accepted into this clinical trial, participants must meet the age-based requirements; they must be at least 18 years old and not over 65."

Answered by AI

Who else is applying?

What state do they live in?

Illinois

North Carolina

Indiana

How old are they?

18 - 65

What site did they apply to?

University of Illinois Chicago

What portion of applicants met pre-screening criteria?

Met criteria

How many prior treatments have patients received?

Why did patients apply to this trial?

In the last four years, I have been able to slowly take off weight. While I have lost way more, due to my yo-yo ing, I am currently down 106lbs. I have been stalled for months and frustrated. I am worried the excess weight is causing additional health related problems I am unaware of.

PatientReceived 1 prior treatment

Recent research and studies

clinicaltrials.govStudy

Alternate Day Fasting, Exercise, and NAFLD

Krista Varady 2019. "Alternate Day Fasting, Exercise, and NAFLD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04004403.

All > Nafld > Obesity