Ozone Exposure and Exercise Intensity

Overseen By Matthew G Skirrow, BSc

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Michael Koehle

Must be taking: Hormonal birth control

Disqualifiers: Smoking history, Respiratory disease, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 8

Duration: 4 weeks

Trial Summary

What is the purpose of this trial?

The project will look to investigate whether exercise during ozone exposure performed for a shorter duration at a higher intensity is more harmful than exercise performed for a longer duration at a lighter intensity. To assess this, participants will perform these exercise conditions with and without ozone exposure and researchers will assess changes in lung function, subjective symptoms, and breathing mechanics to determine which is more harmful.

Research Team

Michael Koehle, MD, PhD

Principal Investigator

University of British Columbia

Eligibility Criteria

This trial is for individuals who can safely perform exercises at varying intensities. Participants must be able to exercise with and without exposure to ozone, as the study aims to understand how different exercise intensities interact with ozone exposure.

Inclusion Criteria

Currently training and/or competing in endurance sport

My VO2max is above the required level for my gender.

Taking hormonal birth control (female participants only)

Exclusion Criteria

I have not had a cold or similar illness in the last 4 weeks.

I currently have symptoms of or am infected with COVID-19.

History of smoking

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

1 visit (in-person)

Baseline Assessment

Participants undergo body plethysmography, spirometry, and a Step-ramp-step test to determine subject characteristics and exercise thresholds

1 day

1 visit (in-person)

Treatment

Participants perform exercise conditions with and without ozone exposure to assess changes in lung function, subjective symptoms, and breathing mechanics

4 weeks

4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

2 visits (in-person)

Treatment Details

Interventions

• Ozone

Trial Overview The trial is testing the effects of exercising under different conditions: heavy intensity with ozone, moderate intensity with ozone, and similar exercises in filtered air without ozone. Researchers will measure lung function, symptoms, and breathing mechanics.

Participant Groups

Group I: Ozone, Moderate Intensity Experimental Treatment 2 Interventions

Participants will exercise for 75 minutes in the moderate intensity domain while exposed to 180 ppb ozone

Group II: Ozone, High Intensity Experimental Treatment 2 Interventions

Participants will exercise for 45 minutes in the heavy intensity domain while exposed to 180 ppb ozone

Group III: Filtered Air, Moderate Intensity Placebo Group 2 Interventions

Participants will exercise for 75 minutes in the moderate intensity domain while exposed to filtered air

Group IV: Filtered Air, Heavy Intensity Placebo Group 2 Interventions

Participants will exercise for 45 minutes in the heavy intensity domain while exposed to filtered air.

Who Is Running the Clinical Trial?

Michael Koehle

Lead Sponsor

Trials

1

Recruited

20+

Natural Sciences and Engineering Research Council, Canada

Collaborator

Trials

63

Recruited

3,000+