Ozone Exposure and Exercise Intensity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how exercise intensity and ozone exposure affect lung health. Researchers seek to determine whether short, intense workouts with ozone (a gas commonly found in air pollution) are more harmful than longer, moderate workouts. Participants will exercise under different conditions, some with ozone and some with clean air, to observe changes in breathing and lung function. This trial suits individuals actively involved in endurance sports who meet specific fitness criteria. As an unphased trial, it offers participants the chance to contribute to important research on environmental impacts on athletic performance.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. However, female participants must be on hormonal birth control.
What prior data suggests that this protocol is safe for participants?
Research shows that breathing in ozone can harm health. Studies have found that it can trigger more asthma attacks, lead to more hospital visits, and even increase the risk of death. Ozone can also cause heart problems and inflammation in the body. During exercise, especially at high intensities, people breathe more deeply and take in more air, which can include pollutants like ozone. This increases exposure to harmful substances during exercise. While exercise is generally beneficial, doing it in areas with high ozone levels can be risky. These findings emphasize the importance of understanding how ozone exposure affects the body, especially during physical activities.12345
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover how different levels of exercise intensity affect the body's response to ozone exposure. Unlike typical studies that might focus on medication or therapies, this trial is unique in examining the impact of environmental factors like ozone on exercise performance and health. By understanding these interactions, scientists hope to provide insights into how environmental pollution affects human health, potentially leading to new guidelines for safe exercise practices in polluted areas.
What evidence suggests that this trial's treatments could be effective?
This trial will compare the effects of ozone exposure at different exercise intensities. Studies have shown that inhaling ozone can impair lung and heart function during exercise. Research has indicated that higher daily ozone levels correlate with more asthma attacks and increased hospital visits. In some cases, ozone exposure has been linked to more heart problems. Evidence suggests that even short-term exposure to ozone can temporarily reduce lung function. Overall, ozone exposure is known to make breathing more difficult and increase certain health risks.16789
Who Is on the Research Team?
Michael Koehle, MD, PhD
Principal Investigator
University of British Columbia
Are You a Good Fit for This Trial?
This trial is for individuals who can safely perform exercises at varying intensities. Participants must be able to exercise with and without exposure to ozone, as the study aims to understand how different exercise intensities interact with ozone exposure.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo body plethysmography, spirometry, and a Step-ramp-step test to determine subject characteristics and exercise thresholds
Treatment
Participants perform exercise conditions with and without ozone exposure to assess changes in lung function, subjective symptoms, and breathing mechanics
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ozone
Trial Overview
The trial is testing the effects of exercising under different conditions: heavy intensity with ozone, moderate intensity with ozone, and similar exercises in filtered air without ozone. Researchers will measure lung function, symptoms, and breathing mechanics.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Placebo Group
Participants will exercise for 75 minutes in the moderate intensity domain while exposed to 180 ppb ozone
Participants will exercise for 45 minutes in the heavy intensity domain while exposed to 180 ppb ozone
Participants will exercise for 75 minutes in the moderate intensity domain while exposed to filtered air
Participants will exercise for 45 minutes in the heavy intensity domain while exposed to filtered air.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Michael Koehle
Lead Sponsor
Natural Sciences and Engineering Research Council, Canada
Collaborator
Citations
Ozone exposure limits cardiorespiratory function during ...
We tested the hypothesis that pulmonary function and exercise capability would be diminished, and symptom development would be increased during peak real-world ...
Health Effects of Ozone in the General Population
Higher daily ozone concentrations are associated with increased asthma attacks, increased hospital admissions, increased daily mortality, and other markers of ...
Exposure to medium and high ambient levels of ozone ...
Epidemiological evidence suggests that exposure to ozone increases cardiovascular morbidity. However, the specific biological mechanisms mediating ...
Ozone Exposure and Exercise Intensity · Info for Participants
The project will look to investigate whether exercise during ozone exposure performed for a shorter duration at a higher intensity is more harmful than ...
The dose-dependent effect of acute ozone exposure on ...
Our results showed that 0.2 ppm ozone was the maximum tolerated dose that elicited a temporal decline in lung function in healthy participants and that BerriQi ...
Exposure to medium and high ambient levels of ozone ...
Inhalation of ozone causes adverse systemic inflammatory and cardiac autonomic effects that may contribute to the cardiovascular mortality associated with ...
Inhalation exposure to indoor air pollutants during moderate
Physical exercise increases pollutant inhalation doses, with high-intensity exercise activities resulting in higher exposures compared to ...
Air Pollution and Endurance Exercise: A Systematic Review of ...
This study highlights that exposure to air pollution during endurance activities, such as cycling and outdoor running, significantly affects cardiopulmonary ...
Impact of air pollution on running performance
Training and competing at elevated air pollution levels, even at exposures within AQI's good-to-moderate classifications, was associated with slower race times.
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