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Ozone Exposure and Exercise Intensity

MG
Overseen ByMatthew G Skirrow, BSc
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Michael Koehle
Must be taking: Hormonal birth control
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The project will look to investigate whether exercise during ozone exposure performed for a shorter duration at a higher intensity is more harmful than exercise performed for a longer duration at a lighter intensity. To assess this, participants will perform these exercise conditions with and without ozone exposure and researchers will assess changes in lung function, subjective symptoms, and breathing mechanics to determine which is more harmful.

Who Is on the Research Team?

MK

Michael Koehle, MD, PhD

Principal Investigator

University of British Columbia

Are You a Good Fit for This Trial?

This trial is for individuals who can safely perform exercises at varying intensities. Participants must be able to exercise with and without exposure to ozone, as the study aims to understand how different exercise intensities interact with ozone exposure.

Inclusion Criteria

Currently training and/or competing in endurance sport
My VO2max is above the required level for my gender.
Taking hormonal birth control (female participants only)
See 1 more

Exclusion Criteria

I have not had a cold or similar illness in the last 4 weeks.
I currently have symptoms of or am infected with COVID-19.
History of smoking
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks
1 visit (in-person)

Baseline Assessment

Participants undergo body plethysmography, spirometry, and a Step-ramp-step test to determine subject characteristics and exercise thresholds

1 day
1 visit (in-person)

Treatment

Participants perform exercise conditions with and without ozone exposure to assess changes in lung function, subjective symptoms, and breathing mechanics

4 weeks
4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks
2 visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Ozone
Trial Overview The trial is testing the effects of exercising under different conditions: heavy intensity with ozone, moderate intensity with ozone, and similar exercises in filtered air without ozone. Researchers will measure lung function, symptoms, and breathing mechanics.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Placebo Group
Group I: Ozone, Moderate IntensityExperimental Treatment2 Interventions
Group II: Ozone, High IntensityExperimental Treatment2 Interventions
Group III: Filtered Air, Moderate IntensityPlacebo Group2 Interventions
Group IV: Filtered Air, Heavy IntensityPlacebo Group2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Michael Koehle

Lead Sponsor

Trials
1
Recruited
20+

Natural Sciences and Engineering Research Council, Canada

Collaborator

Trials
63
Recruited
3,000+
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