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Behavioural Intervention

rTMS for Stimulant Use Disorder (CTN-0108 Trial)

N/A
Waitlist Available
Led By Kathleen T Brady, MD PHD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-65
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from first treatment week (week 1) to end of treatment at 8 weeks
Awards & highlights

CTN-0108 Trial Summary

This trial is testing if a non-invasive brain stimulation technique could help people with cocaine or methamphetamine addiction to cut down or stop use.

Who is the study for?
Adults aged 18-65 with moderate to severe cocaine or methamphetamine use disorder, who have used these substances frequently in the last month and are interested in reducing their usage. Women must agree to use birth control during the study. Participants should not be currently receiving substance use disorder treatment and must be on a stable dose of certain medications if prescribed.Check my eligibility
What is being tested?
The trial is testing repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for cocaine or methamphetamine addiction. Over eight weeks, participants will receive either real rTMS or sham (placebo) rTMS, with follow-ups at the end of treatment and up to 16 weeks after starting.See study design
What are the potential side effects?
While specific side effects are not listed here, rTMS can sometimes cause discomfort at the stimulation site, headache, lightheadedness, or seizures in very rare cases. The placebo group may experience no actual side effects from the sham procedure.

CTN-0108 Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 65 years old.

CTN-0108 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from first treatment session (week 1, first study visit) to end of treatment at 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and from first treatment session (week 1, first study visit) to end of treatment at 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of participants who receive at least 20 sessions of rTMS/sham over the treatment period.
Secondary outcome measures
Percent of negative UDS from weekly UDS

CTN-0108 Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: rTMSActive Control1 Intervention
Participants will receive up to 30 rTMS sessions within the 8-week treatment period.
Group II: Sham (Placebo)Placebo Group1 Intervention
Participants will receive up to 30 sham rTMS sessions within the 8-week treatment period.

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
929 Previous Clinical Trials
7,393,688 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,447 Previous Clinical Trials
2,593,937 Total Patients Enrolled
1 Trials studying Methamphetamine Addiction
8 Patients Enrolled for Methamphetamine Addiction
Kathleen T Brady, MD PHDPrincipal InvestigatorMedical University of South Carolina

Media Library

rTMS (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04907357 — N/A
Methamphetamine Addiction Research Study Groups: rTMS, Sham (Placebo)
Methamphetamine Addiction Clinical Trial 2023: rTMS Highlights & Side Effects. Trial Name: NCT04907357 — N/A
rTMS (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04907357 — N/A
Methamphetamine Addiction Patient Testimony for trial: Trial Name: NCT04907357 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would participants aged 55 and over be eligible for this clinical trial?

"This trial welcomes participants of legal age (above 18) and who are below the pensionable age (less than 65)."

Answered by AI

Are there any unfilled positions for participants in this research project?

"Data from clinicaltrials.gov indicates that the recruitment process for this trial is still underway, having been first posted on 3rd January 2022 and last updated 16th February of the same year."

Answered by AI

To what extent has the trial been implemented across various sites?

"Patients for this clinical study are being recruited from multiple locations, including the Medical University of South carolina in Charleston, Wake Forest School of Medicine in Winston-Salem, and University of Texas Southwestern in Dallas. Additionally, there are 4 other sites that have opened enrollment."

Answered by AI

How many individuals are being recruited for this experiment?

"This medical trial necessitates 160 suitable candidates. Eligible participants may attend either Medical University of South carolina, located in Charleston, or Wake Forest School of Medicine which is situated in Winston-Salem, North carolina."

Answered by AI

Who fulfills the criteria to take part in this trial?

"To be considered for inclusion in the trial, applicants must have a history of cocaine abuse and lie between the age brackets 18-65. A total of 160 people will ultimately participate."

Answered by AI

Who else is applying?

What state do they live in?
Virginia
Texas
How old are they?
18 - 65
What site did they apply to?
Other
University of Texas Health Science Center San Antonio
Wake Forest School of Medicine
University of Texas Southwestern
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+
0

Why did patients apply to this trial?

I’m trying to stop my meth use and start drug court. I would like to not be addicted to methamphetamines anymore.
PatientReceived no prior treatments
I want to get off of this drug.. it's been ruining my life for over 10 years now.
PatientReceived 1 prior treatment
I've never tried any drug replacement therapy treatments. I never saw the use in trying opi.
PatientReceived no prior treatments
I'm 32 been addicted since I was 18. High functioning, would give ANYTHING to not be burdened by my addiction.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

Is this a paid trial? And if so how much? Is it inpatient or outpatient? And how long does the whole trial itself last?
PatientReceived no prior treatments

How responsive is this trial?

Average response time
  • < 1 Day
Typically responds via
Email
Phone Call
Most responsive sites:
  1. Wake Forest School of Medicine: < 24 hours
  2. University of Texas Southwestern: < 24 hours
~5 spots leftby May 2024