Computerized Memory Training for Mild Cognitive Impairment

(COMET Trial)

Overseen By Nicole Nguyen, MA

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Vanderbilt University Medical Center

Must not be taking: Investigational drugs

Disqualifiers: Alzheimer's, Parkinson's, Schizophrenia, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 weeks

19 Participants Needed

Trial Summary

What is the purpose of this trial?

The investigators propose to apply neuroplasticity-based computerized cognitive remediation (nCCR) to improve memory function in patients with Mild Cognitive Impairment (MCI).

Research Team

Alexander C Conley, PhD

Principal Investigator

Vanderbilt University Medical Center

Eligibility Criteria

This trial is for adults aged 55-85 with Mild Cognitive Impairment (MCI), who have memory concerns but not severe dementia or Alzheimer's. Participants must be in good health, not pregnant, and fluent in English. They need a study partner available to assist during the study.

Inclusion Criteria

Have a subjective memory concern as reported by participant, study partner or clinician

Be between 55 and 85 years of age (inclusive)

Clinical Dementia Rating Global score of 0.5

Exclusion Criteria

Residence in a skilled nursing facility

Participants whom the Principal Investigator deems to be otherwise ineligible.

Use of any investigational drugs within 30 days or 5 half-lives, whichever is longer, prior to screening

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive 45 hours of Neuroplasticity-based Computerized Cognitive Remediation (nCCR) to improve memory function

6 weeks

Multiple visits (frequency not specified)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Neuroplasticity-based Computerized Cognitive Remediation

Trial Overview The trial tests a computer program designed to improve memory by using exercises that stimulate brain plasticity. It aims to see if regular use of this cognitive training can enhance memory function in those with MCI.

Participant Groups

Group I: Neuroplasticity-based Computerized Cognitive Remediation Experimental Treatment 1 Intervention

Participants will receive a 45-hour of Neuroplasticity-based Computerized Cognitive Remediation

Who Is Running the Clinical Trial?

Vanderbilt University Medical Center

Lead Sponsor

Trials

922

Recruited

939,000+