MRF + IVIM MRI for Brain Cancer
Trial Summary
What is the purpose of this trial?
The purpose of this study is to discover the potential convenience and ease of using a Magnetic Resonance Imaging (MRI) technique, named Magnetic Resonance Fingerprinting (or MRF), to achieve high-quality images within a short scan time of 5 min for viewing the entire brain. This is an advanced quantitative assessment of brain tissues. This method is being applied with IVIM MRI to be able to tell the difference between a brain with radiation necrosis and a brain with tumor recurrence. Participants will consist of individuals who have received radiation therapy in the past and were diagnosed with radiation necrosis, individuals with recurrent tumors, and healthy individuals who have no brain diseases and have not had radiation treatment to the brain. Participants will undergo an MRI scan at a one-time research study visit; no extra tests or procedures will be required for this research study. The primary objectives of this study are: * To demonstrate the clinical feasibility of combining MRF with state-of-the-art parallel imaging techniques to achieve high-resolution quantitative imaging within a reasonable scan time of 5 min for whole brain coverage. * To apply the developed quantitative approach in combination with IVIM MRI for differentiation of tumor recurrence and radiation necrosis.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It seems focused on MRI imaging and does not mention medication restrictions.
What data supports the effectiveness of the treatment MRF + IVIM MRI for brain cancer?
Is Magnetic Resonance Fingerprinting (MRF) safe for use in humans?
Magnetic Resonance Fingerprinting (MRF) is a new MRI technique that has been used in various clinical applications, including brain and prostate imaging, without specific safety concerns reported in the available research. It is generally considered safe as it is a type of MRI, which is a non-invasive imaging method commonly used in medical practice.24678
How is the MRF + IVIM MRI treatment for brain cancer different from other treatments?
The MRF + IVIM MRI treatment is unique because it combines Magnetic Resonance Fingerprinting (MRF) and Intravoxel Incoherent Motion (IVIM) MRI to provide detailed, quantitative imaging of brain tumors, which can help differentiate between types of gliomas and assess tumor perfusion, potentially aiding in personalized treatment planning.1591011
Research Team
Samuel T. Chao, MD
Principal Investigator
Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center
Lan Lu, PhD
Principal Investigator
Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center
Eligibility Criteria
This trial is for individuals who have had radiation therapy and are diagnosed with either recurrent brain tumors or radiation necrosis. It's also open to healthy people without brain diseases. Participants should not have a history of stroke, cognitive impairments, be able to consent, and have a life expectancy over 6 months.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
MRI Scan
Participants undergo a one-time MRI scan using MRF and IVIM techniques to differentiate between tumor recurrence and radiation necrosis
Follow-up
Participants are monitored for safety and effectiveness after the MRI scan
Treatment Details
Interventions
- MRF in conjunction with IVIM MRI
MRF in conjunction with IVIM MRI is already approved in United States, European Union for the following indications:
- Diagnostic imaging for brain tumors
- Differentiation of tumor recurrence and radiation necrosis
- Diagnostic imaging for brain tumors
- Differentiation of tumor recurrence and radiation necrosis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Case Comprehensive Cancer Center
Lead Sponsor
The Cleveland Clinic
Collaborator