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Procedure

MRF + IVIM MRI for Brain Cancer

N/A

Waitlist Available

Led By Lan Lu, PhD

Research Sponsored by Case Comprehensive Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Biopsy-proven cases of developed recurrent tumor or radiation necrosis

ECOG performance status 0-2.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within the total 30-45 minute scan time

Awards & highlights

Study Summary

This trial aims to help differentiate between brain tumors and radiation necrosis with MRI scan in just 5 minutes.

Who is the study for?

This trial is for individuals who have had radiation therapy and are diagnosed with either recurrent brain tumors or radiation necrosis. It's also open to healthy people without brain diseases. Participants should not have a history of stroke, cognitive impairments, be able to consent, and have a life expectancy over 6 months.Check my eligibility

What is being tested?

The study tests an MRI technique called Magnetic Resonance Fingerprinting (MRF) combined with IVIM MRI without contrast. The goal is to get high-quality images quickly to distinguish between brains affected by tumor recurrence and those with tissue death due to radiation.See study design

What are the potential side effects?

Since the intervention involves only non-invasive imaging techniques like MRF in conjunction with IVIM MRI without contrast, there are typically no direct side effects associated with this procedure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My tumor has come back or I have tissue damage from radiation.

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I can take care of myself and perform daily activities.

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I have never had a stroke or other brain blood vessel issues.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within the total 30-45 minute scan time

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within the total 30-45 minute scan time

This trial's timeline: 3 weeks for screening, Varies for treatment, and within the total 30-45 minute scan time for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Comparison of T1 relaxation times

Comparison of T2 relaxation times

Comparison of blood perfusion in brain tissues

+2 more

Trial Design

3Treatment groups

Experimental Treatment

Group I: Participants with Tumor RecurrenceExperimental Treatment1 Intervention

The MRI scans (MRF and IVIM) will be performed on participants with newly developed recurrent prior to any further therapy implementation, surgical biopsy, or resection. For the participants undergoing surgical biopsy or resection after the MRI scans, the findings from the analysis of pathological biopsied specimen will serve as pathological confirmation for the MRI imaging findings

Group II: Participants with Radiation NecrosisExperimental Treatment1 Intervention

The MRI scans (MRF and IVIM) will be performed on participants with newly developed necrosis prior to any further therapy implementation, surgical biopsy, or resection. For the participants undergoing surgical biopsy or resection after the MRI scans, the findings from the analysis of pathological biopsied specimen will serve as pathological confirmation for the MRI imaging findings

Group III: Healthy Volunteer ParticipantsExperimental Treatment1 Intervention

Healthy volunteers will be recruited to evaluate the capability of MRF in conjunction with intravoxel incoherent motion (IVIM) MRI and serve as healthy control data to compare with the participant data.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Case Comprehensive Cancer CenterLead Sponsor

452 Previous Clinical Trials

31,870 Total Patients Enrolled

The Cleveland ClinicOTHER

1,027 Previous Clinical Trials

1,364,238 Total Patients Enrolled

Lan Lu, PhDPrincipal InvestigatorCleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 50 or older eligible for participation in this medical experiment?

"According to the trial's eligibility criteria, only participants aged between 21 and 60 may enroll. There are 90 trials catering for minors below 18 years of age while 439 studies focus on older people beyond 65 year old individuals."

Answered by AI

Are there any particular demographics that are preferable to incorporate in this medical study?

"The prerequisites for this clinical trial include having a brain tumor and being between 21 to 60 years old. This research project is accepting around 40 participants in total."

Answered by AI

Is it possible to volunteer for this clinical trial at the present time?

"As of the 10th October 2023, clinicaltrials.gov shows that this medical trial has ceased recruitment. Initially posted on January 1st 2024, there are now 510 other studies actively recruiting individuals to participate in their respective interventions."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Development of MRF for Characterization of Brain Tumors After Radiotherapy

2024. "Development of MRF for Characterization of Brain Tumors After Radiotherapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06101069.

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