Exercise Training for Healthy Cognition

Phase-Based Progress Estimates
Healthy CognitionExercise Training - Other
60 - 80
All Sexes
What conditions do you have?

Study Summary

This trial is comparing the effects of six months of moderate exercise to six months of flexibility training on brain function, cognition, and physical function in adults aged 60-80.

Eligible Conditions
  • Healthy Cognition

Treatment Effectiveness

Study Objectives

2 Primary · 2 Secondary · Reporting Duration: Baseline and 6 months

Baseline and 6 months
Change from Baseline to 6 months in 6 Minute Walk Test
Change from Baseline to 6 months in Resting Cerebral Blood Flow
Change from Baseline to 6 months in Rey Auditory Verbal Learning Test Sum of Trials 1-5
Change from Baseline to 6 months in VO2peak

Trial Safety

Trial Design

2 Treatment Groups

Flexibility Control
1 of 2
Exercise Training
1 of 2

Active Control

Experimental Treatment

152 Total Participants · 2 Treatment Groups

Primary Treatment: Exercise Training · No Placebo Group · N/A

Exercise Training
Experimental Group · 1 Intervention: Exercise Training · Intervention Types: Other
Flexibility Control
ActiveComparator Group · 1 Intervention: Flexibility Control · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and 6 months

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,417 Previous Clinical Trials
3,486,403 Total Patients Enrolled
Johns Hopkins UniversityOTHER
2,080 Previous Clinical Trials
31,020,266 Total Patients Enrolled
University of Maryland, College ParkLead Sponsor
143 Previous Clinical Trials
42,025 Total Patients Enrolled
Marquette UniversityOTHER
56 Previous Clinical Trials
202,184 Total Patients Enrolled
University of Maryland, BaltimoreOTHER
610 Previous Clinical Trials
333,645 Total Patients Enrolled
J. Carson Smith, PhDPrincipal InvestigatorUniversity of Maryland

Eligibility Criteria

Age 60 - 80 · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are fluent in English.
You are willing to make the time commitment to participate in the project, including randomization to treatments.
You are 60 to 80 years old.
You are physically inactive for more than 2 days per week for the past 6 months.
You are determined to be safe for MRI.