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Contrast Enhanced Ultrasound for Acute Kidney Injury

N/A

Waitlist Available

Research Sponsored by University of Virginia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

For specific aim 2 - Subjects with normal kidney function: Adult (>18 years of age) men and women of all races and ethnicities being scheduled for a coronary angiography study with estimated GFR greater than or equal to 60 ml/min/1.73 m2

For specific aim 1 - Subjects with reduced kidney function: Adult (>18 years of age) men and women of all races and ethnicities with chronic kidney disease stage 3 and an estimated GFR by MDRD formula between 30 - 59 ml/min/1.73 m2, being scheduled for a coronary angiography study as part of their clinical care

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 - 72 hours

Awards & highlights

Study Summary

This trial looks at whether measuring renal blood flow could help predict which patients are at risk for contrast-induced nephropathy (a type of kidney damage).

Who is the study for?

Adults over 18 with chronic kidney disease stage 3 (eGFR of 30-59 ml/min/1.73 m2) scheduled for coronary angiography can join this trial. A separate group with normal kidney function (eGFR ≥60 ml/min/1.73 m2) is also included. Exclusions apply to those with GFR outside these ranges, history of kidney transplant, certain heart conditions, pregnancy, lactation, allergies to Definity®, or pulmonary hypertension.Check my eligibility

What is being tested?

The study tests if monitoring renal blood flow using contrast enhanced ultrasound (CEU) can predict the risk of contrast induced nephropathy after a coronary angiogram in patients with varying levels of kidney function.See study design

What are the potential side effects?

Potential side effects may include allergic reactions to the perflutren used in CEU and risks associated with volume expansion such as fluid overload. The procedure itself carries standard risks linked to coronary angiograms.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am an adult with normal kidney function scheduled for a heart vessel exam.

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I am an adult with stage 3 chronic kidney disease and a GFR between 30-59, scheduled for a coronary angiography.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 - 72 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 - 72 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 - 72 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Acute Kidney Injury

Secondary outcome measures

Change in novel biomarkers of AKI

Trial Design

1Treatment groups

Experimental Treatment

Group I: Contrast Enhanced UltrasoundExperimental Treatment1 Intervention

Renal blood flow before and after exposure to iodinated contrast agent (perflutren) also known as Definity will be measured using contrast enhanced ultrasound (CEUS).

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of VirginiaLead Sponsor

753 Previous Clinical Trials

1,244,881 Total Patients Enrolled

2 Trials studying Acute Kidney Injury

2,211 Patients Enrolled for Acute Kidney Injury

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,356 Previous Clinical Trials

4,314,916 Total Patients Enrolled

24 Trials studying Acute Kidney Injury

26,650 Patients Enrolled for Acute Kidney Injury

Media Library

Acute Kidney Injury Research Study Groups: Contrast Enhanced Ultrasound

Contrast Enhanced Ultrasound 2023 Treatment Timeline for Medical Study. Trial Name: NCT01544036 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Contrast Enhanced Ultrasound a well-studied medical technique?

"Presently, 19 clinical trials are examining Contrast Enhanced Ultrasound and 1 of them is in its 3rd phase. While Philadelphia, Pennsylvania has the most trials for this medical procedure, there are 26 research sites in total spread across multiple states."

Answered by AI

What is the total number of participants in this medical experiment?

"This trial is not currently in need of recruitment. It was initially posted on February 1st 2012, and last updated December 18th 2013. If you are seeking other trials, 123 opportunities exist for individuals with acute kidney injury while 19 studies focus on Contrast Enhanced Ultrasound searches for participants."

Answered by AI

Does this research undertaking currently have any unfilled positions?

"This particular trial is currently not accepting recruitments, having last been modified on December 18th 2013. For those looking for similar studies, there are 123 medical trials recruiting patients with acute kidney injury and 19 Contrast Enhanced Ultrasound clinical tests actively seeking participants."

Answered by AI

What clinical issues does Contrast Enhanced Ultrasound commonly address?

"Through the use of Contrast Enhanced Ultrasound, echocardiography can be aided. This type of imaging also has potential applications in addressing cardiovascular issues and aiding diagnoses for left ventricular problems."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Monitoring Renal Blood Flow With Contrast Enhanced Ultrasound During Coronary Angiogram

2012. "Monitoring Renal Blood Flow With Contrast Enhanced Ultrasound During Coronary Angiogram". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01544036.

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