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Neurolytic Agent

6% aqueous phenol for Osteoarthritis

Phase 4
Waitlist Available
Led By Paul So, MD
Research Sponsored by Kessler Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Knee pain of moderate intensity or greater (NRS of 4 or greater)
Knee pain for 3 months or longer
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 1 month, 3 months, 6 months
Awards & highlights

Study Summary

This trial is testing whether a nerve-blocking procedure using phenol helps relieve knee pain from osteoarthritis better than a placebo procedure.

Eligible Conditions
  • Osteoarthritis
  • Chronic Knee Pain

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are experiencing moderate to severe knee pain with a rating of 4 or more on a pain scale.
Select...
You have been experiencing knee pain continuously for 3 months or more.
Select...
Your knee has been hurting for a long time, and you have tried different treatments like pain medications, physical therapy, and injections but the pain has not gone away.
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You still have knee pain even after trying different treatments like painkillers, therapy, and injections.
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You have knee pain that is moderate or severe (rated 4 or higher on a pain scale).
Select...
You have been experiencing knee pain for at least three months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 1 month, 3 months, 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 1 month, 3 months, 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in NRS pain score from baseline
Secondary outcome measures
Change in WOMAC score from baseline

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment GroupExperimental Treatment1 Intervention
6% aqueous phenol, 1.5 mL per target site
Group II: Placebo GroupPlacebo Group1 Intervention
Isotonic saline, 1.5 mL per target site

Find a Location

Who is running the clinical trial?

Kessler FoundationLead Sponsor
172 Previous Clinical Trials
10,644 Total Patients Enrolled
2 Trials studying Osteoarthritis
30 Patients Enrolled for Osteoarthritis
Paul So, MDPrincipal InvestigatorKessler Institute for Rehabilitation

Media Library

Osteoarthritis Clinical Trial 2023: 6% aqueous phenol Highlights & Side Effects. Trial Name: NCT04989660 — Phase 4
Osteoarthritis Patient Testimony for trial: Trial Name: NCT04989660 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the FDA recognize 6% aqueous phenol as safe for use?

"Evidence from this Phase 4 trial led to our team at Power assigning 6% aqueous phenol with the highest safety rating of 3."

Answered by AI

Are there any available opportunities to participate in this trial?

"The information on clinicaltrials.gov indicates that this medical trial is accepting new participants. This study was initially unveiled on November 1st 2021, and its parameters were most recently revised at the end of March 2022."

Answered by AI

How many subjects are involved in the current clinical trial?

"Affirmative. Clinicaltrials.gov hosts details that indicate this clinical trial is actively seeking participants, with the first posting being recorded on November 1st 2021 and most recent update posted on March 30th 2022. This study demands a total of 30 subjects at one medical centre to be enrolled in order to complete recruitment goals."

Answered by AI

To what ailments has 6% aqueous phenol been applied as a remedy?

"By using 6% aqueous phenol, individuals can address throat irritation, ringworm, and psoriasis."

Answered by AI

Who else is applying?

What state do they live in?
Pennsylvania
New Jersey
How old are they?
65+
What site did they apply to?
Kessler Institute for Rehabilitation
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
2
3+

Why did patients apply to this trial?

Knee pain for 10 years. Bone on bone. Has. Trying to find another alternative other than replacement.
PatientReceived no prior treatments
I received a email about the trial and I thought that I would give it a try.
PatientReceived 2+ prior treatments
I've tried shots, PT, braces, everything and I sit here crying barely able to stand to take a shower because of the pain.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

Is the a financial incentive for time and transportation costs?
PatientReceived 1 prior treatment
~9 spots leftby Mar 2025