Lactated Ringers for Low Blood Pressure

Overseen By Antoinette Burger, PhD

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: University of Missouri-Columbia

Disqualifiers: Emergency surgeries, Amputations, Heart failure, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 1

100 Participants Needed

Trial Summary

What is the purpose of this trial?

This study aims to determine whether a standardized, weight-based crystalloid fluid bolus administered preoperatively reduces the incidence of postinduction hypotension (PIH) in patients undergoing cystoscopy.

Research Team

Sagar Bansal, MD

Principal Investigator

University of Missouri-Columbia

Eligibility Criteria

This trial is for patients scheduled for elective cystoscopy who may experience low blood pressure after anesthesia induction. Specific eligibility details are not provided, but typically include adults meeting certain health standards.

Inclusion Criteria

Able to provide informed consent

I am scheduled for a bladder examination surgery.

Exclusion Criteria

Past history of amputations of any body part

I am not allergic to any medications used in the study or lactated ringers.

My heart's right ventricle has been severely weak in the past year.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1 week

Preoperative Assessment

Participants receive an ultrasound scan to determine cardiac output and may receive a fluid bolus of Lactated Ringers

Up to 24 hours

1 visit (in-person)

Surgery

Participants undergo cystoscopy with monitoring for postinduction hypotension

Up to 24 hours

Follow-up

Participants are monitored for safety and effectiveness after surgery

1 week

Treatment Details

Interventions

• Lactated Ringers

Trial Overview The study tests if giving a specific amount of Lactated Ringers solution, based on the patient's weight before surgery, can prevent a drop in blood pressure that sometimes happens after anesthesia is given.

Participant Groups

Group I: Preoperative Fluid Bolus Experimental Treatment 1 Intervention

Patients will receive an ultrasound scan on their heart to determine cardiac output and will also receive a fluid bolus of Lactated Ringers before surgery.

Group II: No Treatment Active Control 1 Intervention

Patients will receive an ultrasound scan on their heart to determine cardiac output before surgery, but no fluid bolus will be given.

Who Is Running the Clinical Trial?

University of Missouri-Columbia

Lead Sponsor

Trials

387

Recruited

629,000+