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Monoclonal Antibodies

Active Treatment for Psoriasis

Phase 2
Waitlist Available
Led By Joel Neutel, MD
Research Sponsored by Abcentra
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up weeks 1, 3, 7, 11, 15
Awards & highlights

Study Summary

This trial is testing a new drug for people with psoriasis and heart/metabolism problems to see if it's safe and effective.

Eligible Conditions
  • Psoriasis
  • Coronary Artery Disease
  • Inflammation
  • Cardiometabolic Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~weeks 1, 3, 7, 11, 15
This trial's timeline: 3 weeks for screening, Varies for treatment, and weeks 1, 3, 7, 11, 15 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of Treatment Emergent Adverse Events (TEAEs)
Incidence of abnormal hemodynamic parameters
Incidence of abnormal laboratory tests results
+3 more
Secondary outcome measures
Mean change from Baseline in Dermatology Life Quality Index (DLQI) score
Mean change from Baseline in Itch Numerical Rating Scale (INRS) Score
Mean percent change from Baseline in Psoriasis Area Severity Index (PASI)
+2 more
Other outcome measures
Change in Coronary Artery Inflammation by CCTA
Change in coronary artery plaque burden by CCTA

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Active TreatmentActive Control1 Intervention
Dosage: Repeating intravenous dose. Administered by infusion over 30 minutes. Frequency and duration: once weekly x 4 weeks, then once monthly x 2 months.
Group II: PlaceboPlacebo Group1 Intervention
Dosage: Repeating intravenous dose. Administered by infusion over 30 minutes. Frequency and duration: once weekly x 4 weeks, then once monthly x 2 months.

Find a Location

Who is running the clinical trial?

AbcentraLead Sponsor
Joel Neutel, MDPrincipal InvestigatorOrange County Research Center
11 Previous Clinical Trials
525 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there other scientific research projects that have studied Active Treatment?

"One clinical trial is currently underway for Active Treatment. None of the trials are in Phase 3, however. The majority of research sites for Active Treatment are located in Indianapolis, Indiana--though there are a total of 13 different locations running these trials."

Answered by AI

Does Active Treatment have FDA approval?

"While there is some evidence backing Active Treatment's safety, it remains unproven whether or not the intervention is effective. Consequently, it received a score of 2."

Answered by AI

Can people with the specified condition join this research project at this time?

"The clinicaltrials.gov website reports that this study is not currently looking for candidates. The trial was first posted on 6/30/2021 and was last updated on 9/8/2022; however, there are 1242 other trials which are presently recruiting patients."

Answered by AI

What are the goals that researchers are hoping to achieve with this trial?

"The goal of this 106-day clinical trial is to assess the incidence of serious adverse events (SAEs). Additionally, the study will track mean changes in itch severity (as measured by the Itch NRS scale) and quality of life (as measured by the DLQI questionnaire). Finally, the percentage of participants achieving a 75% or 50% reduction in PASI score will be monitored."

Answered by AI

Would you happen to know how many places are running this experiment?

"Currently, there are 13 sites where this study is recruiting patients from. The locations include Scottsdale, Tustin and Jacksonville among other places. If you are interested in participating, please choose the clinic that is nearest to you to reduce travel time requirements."

Answered by AI

What is unique about this clinical research?

"Active Treatment has been researched since 2021 when Abcentra ran the first clinical trial. 77 patients were studied in order to help Active Treatment reach Phase 2 of drug approval. As of now, there is only one ongoing study being conducted by Abcentra."

Answered by AI

How many test subjects are involved in this clinical trial?

"Unfortunately, this study is no longer recruiting patients. It was originally posted on June 30th, 2021 but has not been updated since September 8th, 2022. If you are looking for other studies, there are 1241 trials actively recruiting patients with coronary artery disease and 1 study for Active Treatment that is currently seeking participants."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
A Proof-of-Activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors
2021. "A Proof-of-Activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04776629.
~21 spots leftby Apr 2025
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