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Venetoclax for Chronic Lymphocytic Leukemia
Study Summary
This trial is studying venetoclax in people with relapsed or refractory chronic lymphocytic leukemia. Venetoclax will be given to see if it can help to control the disease.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My bone marrow is failing and getting worse.I am not currently pregnant or nursing.I have anemia or low platelet count.I have lost 10% or more of my weight in the last 6 months.I am currently receiving treatment for cancer.I am 18 years old or older.I understand this is a research study and I can give my consent.I experience extreme tiredness that doesn't improve with rest.I am not taking strong CYP3A4 inhibitor medications.My cancer doctor will continue my venetoclax treatment after the initial phase.My spleen is significantly enlarged or getting worse.My condition has transformed into a more aggressive form known as Richter's.I have had a fever over 100.5 F for 2 weeks or more without signs of infection.My low blood cell counts are due to my CLL and expected to improve with treatment.I have had night sweats for over a month without being sick.I am able to care for myself and perform daily activities.I have uncontrolled autoimmune blood disorders.I do not have any ongoing infections that aren’t being treated.I have never been treated with BCL-2 inhibitors.I have another cancer that is getting worse or needs treatment.I have been tested for allopurinol hypersensitivity.My condition significantly impacts my stomach or intestine's ability to function or absorb nutrients.My condition is officially diagnosed as CLL/SLL.I have been tested for G6PD to see if I can receive rasburicase.My lymph nodes are significantly enlarged or worsening.
- Group 1: Relapsed/Refractory CLL pts
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Can adults within a certain age range participate in this research study?
"This clinical trial is open to patients aged 18-90. There are 469 other studies available for minors and 1491 research options for senior citizens."
What are the possible side effects associated with taking Venetoclax?
"While there is some evidence to support the safety of Venetoclax, it did not receive a higher score because this is only a Phase 2 trial. This means that while there are data supporting safety, there are no reports indicating its efficacy."
Could you give me the screening criteria for this research project?
"Up to 55 patients, who are between 18 and 90 years old and have leukemia, will be included in this trial. To qualify for the study, participants must also suffer from fatigue, night sweats (with no evidence of infection), large nodes or clusters, progressive lymphadenopathy, weight loss of 10% or more in the last 6 months, fevers of 100.5 F or higher for 2 weeks or more (without evidence of infection), massive or progressive splenomegaly."
Are people still able to join this clinical trial?
"The study is still recruiting patients, according to the information available on clinicaltrials.gov. This trial was first posted on June 26th, 2019 and was last updated on October 1st, 2022."
Has Venetoclax been researched before in other clinical trials?
"As of now, there are 226 clinical trials involving During Venetoclax with 29 in Phase 3. Most investigations for During Venetoclax are happening in Boston, Massachusetts; however, there are 7269 locations running these tests."
How many guinea pigs are currently testing this new medication?
"That is correct, the most recent information available on clinicaltrials.gov demonstrates that this trial is still recruiting patients. This study was first posted on June 26th, 2019 and has been updated as recently as October 1st, 2020. 55 participants are needed from 1 site to complete this research."
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