24 Participants Needed

Cognitive and Physical Training for COPD

DR
Overseen ByDmitry Rozenberg, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University Health Network, Toronto
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

Cognitive and physical function impairments are common in patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Research has shown that cognitive and physical exercise training may be a beneficial strategy to improve physical and cognitive performance in COPD patients; however, interventions combining physical and cognitive training have not been evaluated in this population. The objectives of this research are i) to evaluate the feasibility of an 8-week home-based cognitive-physical training program in COPD patients; and ii) to derive preliminary estimates on intervention efficacy with cognitive-physical training on dual-task performance, physical function, activities of daily living, and health-related quality of life. Related to our research objectives, we hypothesize that i) it will be feasible to safely recruit COPD patients into a home-based cognitive physical training program with 75% adherence and high satisfaction ratings with the prescribed training; and that ii) the combination of cognitive and physical training will be superior to physical training alone for improving dual-task and cognitive performance, physical function, activities of daily living, and health-related quality of life.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Cognitive-Physical Training, Physical Training for COPD?

Research shows that physical training, including both endurance and strength exercises, is crucial for improving muscle strength and overall physical function in COPD patients. Additionally, cognitive function is linked to physical performance, suggesting that combining cognitive and physical training could enhance balance and movement in COPD patients.12345

Is cognitive and physical training safe for people with COPD?

Research shows that combining cognitive and physical training is generally safe for people with COPD, as it improves exercise endurance and cognitive performance without reported safety issues.26789

How is Cognitive-Physical Training different from other treatments for COPD?

Cognitive-Physical Training for COPD is unique because it combines cognitive training with physical rehabilitation, aiming to improve both mental and physical functions in patients. This dual approach addresses cognitive impairments and physical deconditioning, which are common in COPD, unlike traditional treatments that often focus solely on physical exercise.2671011

Research Team

DR

Dmitry Rozenberg, MD PhD

Principal Investigator

University Health Network, Toronto

Eligibility Criteria

This trial is for adults over 50 with COPD, which is a lung condition that makes it hard to breathe. They should be able to move on their own and have internet access. It's not for people outside this group or those who can't safely do the exercises.

Inclusion Criteria

I have been diagnosed with COPD and my lung function is between 30-80%.
I can move around on my own safely, with or without help like a cane.
I am 50 years old or older.
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Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Baseline assessments including cognitive function, demographics, and physical activity levels

1 week
1 visit (virtual)

Treatment

Participants undergo 8 weeks of home-based cognitive and/or physical training

8 weeks
Weekly follow-up video calls

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks
2 visits (virtual)

Treatment Details

Interventions

  • Cognitive-Physical Training
  • Physical Training
Trial OverviewThe study tests an 8-week home program combining brain games and physical exercise to see if it helps improve thinking, moving, daily activities, and life quality in COPD patients compared to just physical exercise.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Physical Training (PT)Experimental Treatment1 Intervention
Participants in the PT group will perform eight weeks of home-based physical exercise training.
Group II: Cognitive-Physical Training (C-PT)Experimental Treatment2 Interventions
Participants in the C-PT will perform eight weeks of home-based cognitive and physical training.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University Health Network, Toronto

Lead Sponsor

Trials
1,555
Recruited
526,000+

Canadian Institutes of Health Research (CIHR)

Collaborator

Trials
1,417
Recruited
26,550,000+

Boehringer Ingelheim

Industry Sponsor

Trials
2,566
Recruited
16,150,000+

References

"Can do, don't do" are not the lazy ones: a longitudinal study on physical functioning in patients with COPD. [2021]
[Chronic obstructive pulmonary disease and sports]. [2006]
An evaluation of the short physical performance battery following pulmonary rehabilitation in patients with chronic obstructive pulmonary disease. [2023]
Impact of cognitive capacity on physical performance in chronic obstructive pulmonary disease patients: A scoping review. [2023]
Pulmonary Rehabilitation and Physical Activity in Patients with Chronic Obstructive Pulmonary Disease. [2022]
Effect of a pulmonary rehabilitation program combined with cognitive training on exercise tolerance and cognitive functions among Tunisian male patients with chronic obstructive pulmonary disease: A randomized controlled trial. [2023]
Effects of combined training vs aerobic training on cognitive functions in COPD: a randomized controlled trial. [2018]
Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease. [2022]
[Cognitive function in patients with chronic obstructive pulmonary disease]. [2022]
[Medical therapy by training in the rehabilitation of patients with COPD]. [2019]
Respiratory Muscle Training Can Improve Cognition, Lung Function, and Diaphragmatic Thickness Fraction in Male and Non-Obese Patients with Chronic Obstructive Pulmonary Disease: A Prospective Study. [2022]