Cognitive and Physical Training for COPD

DR
Overseen ByDmitry Rozenberg, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University Health Network, Toronto
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how combining cognitive and physical exercises might help individuals with Chronic Obstructive Pulmonary Disease (COPD) enhance their physical and mental abilities. Participants will either engage in both cognitive and physical exercises at home or focus solely on physical training to determine which approach is more effective. The trial targets those with COPD who can move independently and have a reliable internet connection. This research could improve everyday tasks and overall quality of life for individuals living with COPD. As an unphased trial, it presents a unique opportunity to contribute to innovative research that could enhance daily living for COPD patients.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Studies have shown that exercise can improve thinking skills in older people with COPD, indicating it is generally safe and well-tolerated. Specifically, research suggests that high-intensity interval training (HIIT) can enhance quality of life and ease breathing for COPD patients.

Other studies have found that beginning exercise early during a hospital stay is safe for adults with COPD, helping them become stronger and more active.

In summary, various studies report that both mental and physical exercises are safe for people with COPD. They appear to be well-tolerated and can lead to better physical and mental performance.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores a novel approach to managing COPD by combining cognitive and physical training. Unlike traditional treatments that primarily focus on physical rehabilitation or medications targeting lung function, this method aims to enhance both mental and physical health, potentially improving overall well-being and quality of life for COPD patients. The cognitive-physical training program is unique as it leverages home-based exercises, making it more accessible and convenient for participants, which might lead to better adherence and outcomes. By integrating cognitive exercises, the trial seeks to address not just the physical symptoms but also the cognitive challenges often associated with COPD, offering a more holistic approach to treatment.

What evidence suggests that this trial's treatments could be effective for COPD?

Research has shown that combining mental and physical exercises can benefit people with COPD. In this trial, participants in the Cognitive-Physical Training (C-PT) arm will follow a home-based program that integrates mental and physical activities, which has shown promise in enhancing skills needed for everyday tasks. Participants in the Physical Training (PT) arm will engage in home-based physical exercise training. Studies have found that exercise can enhance brain function in those with COPD, and physical exercise alone has effectively improved functional ability and overall well-being in COPD patients. Overall, using both mental and physical exercises together might lead to even greater improvements in both brain and body functions.12678

Who Is on the Research Team?

DR

Dmitry Rozenberg, MD PhD

Principal Investigator

University Health Network, Toronto

Are You a Good Fit for This Trial?

This trial is for adults over 50 with COPD, which is a lung condition that makes it hard to breathe. They should be able to move on their own and have internet access. It's not for people outside this group or those who can't safely do the exercises.

Inclusion Criteria

I have been diagnosed with COPD and my lung function is between 30-80%.
I can move around on my own safely, with or without help like a cane.
I am 50 years old or older.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Baseline assessments including cognitive function, demographics, and physical activity levels

1 week
1 visit (virtual)

Treatment

Participants undergo 8 weeks of home-based cognitive and/or physical training

8 weeks
Weekly follow-up video calls

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks
2 visits (virtual)

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive-Physical Training
  • Physical Training
Trial Overview The study tests an 8-week home program combining brain games and physical exercise to see if it helps improve thinking, moving, daily activities, and life quality in COPD patients compared to just physical exercise.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Physical Training (PT)Experimental Treatment1 Intervention
Group II: Cognitive-Physical Training (C-PT)Experimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University Health Network, Toronto

Lead Sponsor

Trials
1,555
Recruited
526,000+

Canadian Institutes of Health Research (CIHR)

Collaborator

Trials
1,417
Recruited
26,550,000+

Boehringer Ingelheim

Industry Sponsor

Trials
2,566
Recruited
16,150,000+

Citations

Impact of exercise training on cognitive function in patients ...A systematic review and meta-analysis of RCTs indicates exercise training can improve cognitive performance to varying degrees in people with COPD.
Cognitive and Physical Training in Patients with Chronic ...Cognitive and physical function impairments are common in patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD).
3.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/37436794/
Feasibility of a Home-Based Cognitive-Physical Exercise ...A supervised home-based cognitive-physical training program may be an accessible intervention to improve dual-tasking ability in people living with COPD.
Benefits of pulmonary rehabilitation in COPD patients with ...Twenty-five COPD patients (42%) presented evidence of mild CI prior to PR. Both, CI and CN patients significantly improved global cognitive function, health ...
Effects of cognitive behavioral therapy in patients with chronic ...This review demonstrated that CBT improves the lung function, anxiety and depressive symptoms, treatment compliance, and quality of life of patients with COPD.
Feasibility of a Home-Based Cognitive-Physical Exercise ...We hypothesize that it will be feasible to safely recruit patients with COPD into a home-based cognitive-physical training program with 75% adherence and high ...
High-intensity interval training improves the outcomes of ...HIIT improved the quality of life (SMD = 0.30, 95%CI: 0.06–0.54) and reduced the dyspnea (SMD = −0.27, 95%CI: −0.51∼-0.03) in COPD patients (all ...
Effectiveness of a Long-term Home-Based Exercise ...The strength training program had no effect on dyspnea or other patient-reported outcomes in patients with COPD after 1 year, but show beneficial effects.
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