CASCADE (CAre Supporters Coached to be Adept DEcision partners) for Family Members

Phase-Based Estimates
2
Effectiveness
3
Safety
University of Alabama at Birmingham, Birmingham, AL
+1 More
CASCADE (CAre Supporters Coached to be Adept DEcision partners) - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Family Members

Study Summary

Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial

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Eligible Conditions

  • Family Members
  • Malignancies

Treatment Effectiveness

Effectiveness Estimate

2 of 3
This is better than 85% of similar trials

Study Objectives

This trial is evaluating whether CASCADE (CAre Supporters Coached to be Adept DEcision partners) will improve 1 primary outcome and 5 secondary outcomes in patients with Family Members. Measurement will happen over the course of Baseline to 24 weeks.

Baseline to 24 weeks
Caregiver distress as measured by the Hospital Anxiety and Depression Scale
Caregiver quality of life as measured by the PROMIS Global Health 10
Patient distress as measured by the Hospital Anxiety and Depression Scale
Patient healthcare utilization including advance directive completion as reported by family caregivers
Patient quality of life as measured by the PROMIS Global Health 10
Patient reported decisional conflict using the Decisional Conflict Scale

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Trial Design

16 Treatment Groups

No Control Group
Basic social support + Ottawa guide + monthly follow up calls for 24 weeks

This trial requires 352 total participants across 16 different treatment groups

This trial involves 16 different treatments. CASCADE (CAre Supporters Coached To Be Adept DEcision Partners) is the primary treatment being studied. Participants will be divided into 16 treatment groups. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.

Basic social support + Ottawa guide + monthly follow up calls for 24 weeks
Behavioral
2 in-person/telephone weekly sessions on providing social support, decision support tools, and monthly follow-up calls for 6 months
Advanced social support + communication + monthly follow up calls for 24 weeks
Behavioral
4 in-person/telephone weekly sessions on providing social support, tips for good communication, and monthly follow-up calls for 6 months
Advanced social support + communication + 1 monthly follow up call
Behavioral
4 in-person/telephone weekly sessions on providing social support, tips for good communication, and a single monthly follow-up call
Basic social support + monthly follow up calls for 24 weeks
Behavioral
1 in-person/telephone weekly sessions on providing social support and monthly follow-up calls for 6 months
Advanced social support + communication + Ottawa guide + monthly follow up calls for 24 weeks
Behavioral
5 in-person/telephone weekly sessions on providing social support, tips for good communication, decision support tools, and monthly follow-up calls for 6
Basic social support + communication + Ottawa guide + monthly follow up calls for 24 weeks
Behavioral
3 in-person/telephone weekly sessions on providing social support, tips for good communication, decision support tools, and monthly follow-up calls for 6 months
Basic social support + communication + monthly follow up calls for 24 weeks
Behavioral
2 in-person/telephone weekly sessions on providing social support, tips for good communication, and monthly follow-up calls for 6 months
Advanced social support + communication + Ottawa guide + 1 monthly follow up call
Behavioral
5 in-person/telephone weekly sessions on providing social support, tips for good communication, decision support tools, and a single monthly follow-up call
Advanced social support + Ottawa guide + monthly follow up calls for 24 weeks
Behavioral
4 in-person/telephone weekly sessions on providing social support, decision support tools, and monthly follow-up calls for 6 months
Advanced social support + Ottawa guide + 1 monthly follow up call
Behavioral
4 in-person/telephone weekly sessions on providing social support, decision support tools, and a single monthly follow-up call
Basic social support + 1 monthly follow up call
Behavioral
1 in-person/telephone weekly sessions on providing social support and a single monthly follow-up call
Advanced social support + 1 monthly follow up call
Behavioral
3 in-person/telephone weekly sessions on providing social support, and a single monthly follow-up call
Advanced social support + monthly follow up calls for 24 weeks
Behavioral
3 in-person/telephone weekly sessions on providing social support, and monthly follow-up calls for 6 months
Basic social support + communication + 1 monthly follow up call
Behavioral
2 in-person/telephone weekly sessions on providing social support, tips for good communication, and a single monthly follow-up call
Basic social support + Ottawa guide + 1 monthly follow up call
Behavioral
2 in-person/telephone weekly sessions on 1 coaching session on providing social support, decision support tools, and a single monthly follow-up call
Basic social support + communication + Ottawa guide + 1 monthly follow up call
Behavioral
3 in-person/telephone weekly sessions on providing social support, tips for good communication, decision support tools, and a single monthly follow-up call
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CASCADE (CAre Supporters Coached to be Adept DEcision partners)
2019
N/A
~100

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline to 24 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline to 24 weeks for reporting.

Who is running the study

Principal Investigator
J. N. D.
Prof. James N Dionne-Odom, Assistant Professor
University of Alabama at Birmingham

Closest Location

University of Alabama at Birmingham - Birmingham, AL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
FAMILY CAREGIVERS
≥21 years of age;
self-endorsing or identified by the patient as "a relative, friend, or partner that has a close relationship with you and who assists you with your medical decisions and who may or may not live in the same residence as you and who is not paid for their help";
caring for a patient with advanced-stage cancer (see definition under Patient Inclusion criteria below);
caregivers will need to have an agreeable patient willing to participate in the study for data collection;
English-speaking and able to complete baseline measures.

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get family members a year in the United States?

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Around 20 million American citizens have one or more major problems with a family member each year. This supports that the majority of patients suffering from MDD develop their disorder as a result of negative experiences with family members.

Unverified Answer

Can family members be cured?

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The risk of relatives developing a curable cancer is high for prostate cancer (18%) and breast cancer (11%); however, the risk is very low for ovarian cancer (1%). A risk has been identified for siblings, who, although not diagnosed at the time of diagnosis, did have a two-fold increased risk of dying from a previously diagnosed cancer.

Unverified Answer

What are common treatments for family members?

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The treatments received by patients differed from those recommended in the guidelines for their family members. Interventions may be needed to assist individuals with family members with complex chronic problems in the context of their social relationships.

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What are the signs of family members?

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The most common sign for family members is change in behavior. Common signs of relatives are memory problems, dizziness and constipation. Other less common signs are muscle atrophy, dizziness or vertigo, hearing problems, change in sleep, dizziness and blurred vision. As individuals ages, they commonly show signs of dementia.

Unverified Answer

What causes family members?

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Depression may be caused by many factors, including emotional health, family history, stressful experiences, attitudes and beliefs, and physical health problems. There are currently many research gaps about the causes of depression in family members. At a basic level, family members often have psychological, physical and social health problems but are often not aware of them despite their effect on their mental health. More study is required about this and how to manage and care for family members with depression.

Unverified Answer

What is family members?

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Family members and the whole family contribute to the well being and coping of everyone affected by rheumatoid arthritis and are both important sources and recipients of information, support, care and treatment. It is especially important for patients, and for health care professionals who provide information, support, treatment and rehabilitation, to inform and educate family members of their role and part in the care process.

Unverified Answer

What are the latest developments in cascade (care supporters coached to be adept decision partners) for therapeutic use?

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More research is needed to determine the effectiveness of cascade in the therapeutic use scenario. To date, there is insufficient empirical evidence to support use of cascade for therapeutic interventions.

Unverified Answer

Who should consider clinical trials for family members?

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Given that a quarter of cancer patients want their family members to know about clinical trials, and the fact that over one-third of people with solid cancer, especially those living with solid tumors, and over 70% of people with solid cancers who are already receiving treatment would like clinical trials for them, it would make sense to try to recruit family members of cancer patients in clinical trials. There are various ways to approach this, and it should be discussed with family members. At the very least, clinicians who intend to enroll patients in clinical trials of their own should take the initiative to offer these therapies to their patients' family members.

Unverified Answer

What is the primary cause of family members?

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While the primary cause of family members are unknown, a significant percentage of the family members had many risk factors in common. The risk factors for familial PC include a previous history of PC, smoking history, and advanced age. While there is not a single cause for family members with PC, early detection of this disease could result in improved outcomes. The risk factors for family members are also highly relevant for diagnosis and treatment. As well, the risk factors for family members include a family history.\n

Unverified Answer

What does cascade (care supporters coached to be adept decision partners) usually treat?

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Care cascade has been defined as a complex care-giving role, which can be trained in family support groups that focus on care cascade and trained facilitators, most usually from the community, using a process grounded in 'cascade practice' and the carers own experiences. If cascade training can be integrated into the practice supported by the care support team there could be benefits across the family.

Unverified Answer

Is cascade (care supporters coached to be adept decision partners) safe for people?

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Cascade is a well-established approach to enhancing safety and competence for care in hospice and palliative care. In spite of its longstanding popularity and evidence base, researchers and clinicians still have few rigorous studies that seek to evaluate its effectiveness. This issue has led to skepticism about the validity and generalisability of cascade models. Findings from a recent study is important in developing the evidence base to inform policy makers and healthcare providers about what cascade interventions work.

Unverified Answer

Does cascade (care supporters coached to be adept decision partners) improve quality of life for those with family members?

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Findings from a recent study suggest cascade training may result in improvements in decision-making quality of care. This may help patients and their families manage the day-to-day activities related to health and treatment. However, these results should be obtained in a greater sample and repeated over a longer period of time.

Unverified Answer
See if you qualify for this trial
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