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Gonadotropin-Releasing Hormone (GnRH) Agonist

Leuprolide acetate for Obesity

N/A
Waitlist Available
Led By Edward Melanson, Ph.D.
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5-6 hrs
Awards & highlights

Study Summary

This trialinvestigates how hormones affect brown fat in humans, to see if they affect energy expenditure. They will use imaging and temperature tests to measure the effects.

Eligible Conditions
  • Obesity
  • Menopause

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5-6 hrs
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5-6 hrs for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brown Adipose Tissue Activity - ColdExposure
Brown Adipose Tissue Activity -Warm Exposure
Brown Adipose Tissue Volume
Secondary outcome measures
Resting energy expenditure - after cold exposure
Resting energy expenditure - before cold exposure

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Pre-menopausal womenExperimental Treatment1 Intervention
To determine if natural declines in endogenous E2 contribute to changes in BAT activity, the investigators will compare BAT activity in pre-and post-menopausal women. We will also explore whether suppression of ovarian hormones in pre-menopausal women (using leuprolide acetate) impairs BAT activity.
Group II: Post-menopausal womenActive Control1 Intervention
To determine if natural declines in endogenous E2 contribute to changes in BAT activity, the investigators will compare BAT activity in pre-and post-menopausal women.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Leuprolide
FDA approved

Find a Location

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor
1,725 Previous Clinical Trials
2,141,558 Total Patients Enrolled
100 Trials studying Obesity
213,602 Patients Enrolled for Obesity
University of OttawaOTHER
202 Previous Clinical Trials
264,487 Total Patients Enrolled
7 Trials studying Obesity
304 Patients Enrolled for Obesity
Université de SherbrookeOTHER
289 Previous Clinical Trials
68,861 Total Patients Enrolled
13 Trials studying Obesity
2,563 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is Leuprolide acetate commonly applied medicinally?

"Leuprolide acetate is a medication commonly used to treat advanced prostatic cancer. Additionally, it has been clinically proven to address anemia, central precocious puberty (CPP), and certain other conditions indicated by medical signs."

Answered by AI

What is the capacity of participants in this research endeavor?

"Affirmative. Information on clinicaltrials.gov indicates that this medical experiment is presently looking for participants, having been introduced to the public on January First 2017 and edited most recently October Thirty-First 2022. 72 test subjects are being recruited from a single centre."

Answered by AI

Is this medical trial accepting participants presently?

"Affirmative. According to clinicaltrials.gov's records, this trial is currently fielding applicants and was initially posted on the 1st of January 2017 with its most recent update being made on October 31st 2022. 72 participants are needed from a single site."

Answered by AI

What criteria do individuals need to fulfill in order to be eligible for participation in this experiment?

"The criteria for participation in this experiment necessitates that individuals must be suffering from obesity and aged between 18 and 99. Currently, 72 patients are being enrolled into the study."

Answered by AI

Are there any existing reports on the usage of Leuprolide acetate in medical research?

"Presently, there are 64 ongoing studies concerning Leuprolide acetate of which 24 have reached Phase 3. While most research on this subject is centred around Duarte, California, the total number of sites conducting clinical trials for Leuprolide acetate stands at 5355."

Answered by AI

Could adults over the age of 18 participate in this trial?

"Potential participants in this medical experiment must be aged between 18 and 99 years old."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
University of Colorado Anschutz Medical Campus
What portion of applicants met pre-screening criteria?
Did not meet criteria
~9 spots leftby Mar 2025