Radiation Therapy for Esophageal Cancer

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Dayton Physicians LLC - Troy, Troy, OHEsophageal Cancer+27 MoreRadiation Therapy - Radiation
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This trial is testing if a combination of immunotherapy drugs, chemotherapy, and radiation therapy can shrink tumors more effectively than chemotherapy and radiation therapy alone in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery.

Eligible Conditions
  • Esophageal Cancer
  • Esophageal Adenocarcinoma
  • Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma
  • Gastroesophageal Junction Adenocarcinoma
  • Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma
  • Pathologic Stage IIA Esophageal Adenocarcinoma
  • Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma
  • Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma
  • Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma
  • Esophageal Adenocarcinoma Stage IIB
  • Pathologic Stage III Gastroesophageal Junction Adenocarcinoma
  • Pathologic Stage II Esophageal Adenocarcinoma
  • Pathologic Stage IC Gastroesophageal Junction Adenocarcinoma
  • Pathologic Stage II Gastroesophageal Junction Adenocarcinoma
  • Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma
  • Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma

Treatment Effectiveness

Effectiveness Progress

1 of 3

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1
Atezolizumab
1
Radiation Therapy
1
Intensity-Modulated Radiation Therapy

Study Objectives

2 Primary · 3 Secondary · Reporting Duration: Up to 7 years

Baseline to mid-treatment
Percent change in mean volumetric apparent diffusion coefficient (ADC)
Year 7
Disease-free survival (DFS) (Step 2)
Year 7
DFS
Overall survival
Up to 5 weeks
Pathologic complete response (Step I)
Up to 7 years
Incidence of adverse events

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Similar Trials

2
Atezolizumab
1
Radiation Therapy
1
Intensity-Modulated Radiation Therapy

Trial Design

4 Treatment Groups

Arm B (carboplatin, paclitaxel, radiation therapy, nivolumab)
1 of 4
Arm C (nivolumab)
1 of 4
Arm D (nivolumab, ipilimumab)
1 of 4
Arm A (carboplatin, paclitaxel, radiation therapy)
1 of 4

Experimental Treatment

278 Total Participants · 4 Treatment Groups

Primary Treatment: Radiation Therapy · No Placebo Group · Phase 2 & 3

Arm B (carboplatin, paclitaxel, radiation therapy, nivolumab)Experimental Group · 6 Interventions: Computed Tomography, Positron Emission Tomography, Carboplatin, Paclitaxel, Radiation Therapy, Nivolumab · Intervention Types: Procedure, Procedure, Drug, Drug, Radiation, Biological
Arm C (nivolumab)Experimental Group · 2 Interventions: Computed Tomography, Nivolumab · Intervention Types: Procedure, Biological
Arm D (nivolumab, ipilimumab)Experimental Group · 3 Interventions: Computed Tomography, Ipilimumab, Nivolumab · Intervention Types: Procedure, Biological, Biological
Arm A (carboplatin, paclitaxel, radiation therapy)Experimental Group · 5 Interventions: Computed Tomography, Positron Emission Tomography, Carboplatin, Paclitaxel, Radiation Therapy · Intervention Types: Procedure, Procedure, Drug, Drug, Radiation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Computed Tomography
2017
Completed Phase 2
~3410
Ipilimumab
FDA approved
Positron Emission Tomography
2008
Completed Phase 2
~2800
Carboplatin
FDA approved
Paclitaxel
FDA approved
Radiation Therapy
2017
Completed Phase 3
~7130
Nivolumab
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 7 years

Who is running the clinical trial?

National Cancer Institute (NCI)Lead Sponsor
13,153 Previous Clinical Trials
41,162,646 Total Patients Enrolled
Jennifer R EadsPrincipal InvestigatorECOG-ACRIN Cancer Research Group
1 Previous Clinical Trials
2 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
References

Frequently Asked Questions

Can new patients join this research project?

"Yes, this trial is seeking participants and was last updated on November 12th, 2022. The listing was originally posted on January 17th, 2019." - Anonymous Online Contributor

Unverified Answer

Are there any other papers that mention Radiation Therapy?

"City of Hope Comprehensive Cancer Center first began studying Radiation Therapy in 1997. Since then, a total of 2020 clinical trials have completed with 1958 live studies. Many of these ongoing trials are based out of Carlisle, Pennsylvania." - Anonymous Online Contributor

Unverified Answer

At how many different hospitals is this experiment being conducted?

"At the moment, this trial is looking for participants from 100 different sites. The locations include Carlisle, Matthews and Appleton; in addition to other cities that are closer to you to minimize travel time if selected for the study." - Anonymous Online Contributor

Unverified Answer

For what sorts of medical conditions is Radiation Therapy commonly used?

"Radiation therapy is a cancer treatment that uses high-energy x-rays or particles to kill cancer cells. Radiation therapy can also be used to treat other conditions like unresectable melanoma, squamous cell carcinoma, and high risk of recurrence." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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