CLINICAL TRIAL

Aspirin 80 mg EC Tab for Diabetes Mellitus, Type 2

Recruiting · 18+ · All Sexes · Montréal, Canada

This study is evaluating whether a drug called enteric coated aspirin can be used to treat type 2 diabetes.

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About the trial for Diabetes Mellitus, Type 2

Eligible Conditions
Diabetes Mellitus, Type 2 · Diabetes Mellitus

Treatment Groups

This trial involves 2 different treatments. Aspirin 80 Mg EC Tab is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Aspirin 80 mg EC Tab
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 8 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
2-h Plasma Glucose (2h-PG) ≥200 mg/dL (11.1 mmol/L) during the oral glucose tolerance test (OGTT);
Willing to attend all study visits.
Age ≥ 18 years;
Participant must be naïve to aspirin, defined as absence of chronic treatment with aspirin within the previous 3 months, and of any aspirin use within the previous 2 weeks;
Type 2 diabetes, based on at least one of the following criteria: (5)
Chronic treatment with oral antihyperglycemic agents or insulin therapy;
Fasting Plasma Glucose (FPG) ≥ 126 mg/dL (7.0 mmol/L) (fasting is defined as no caloric intake for at least 8h);
A1C ≥ 6.5% (48 mmol/mol);
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 7 days.
Screening: ~3 weeks
Treatment: Varies
Reporting: 7 days.
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 7 days..
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Aspirin 80 mg EC Tab will improve 1 primary outcome and 2 secondary outcomes in patients with Diabetes Mellitus, Type 2. Measurement will happen over the course of 7 days..

Incomplete platelet aggregation inhibition by aspirin at 7 days.
7 DAYS.
Incomplete platelet aggregation inhibition will be defined as ≥ 20% of residual platelet aggregation in response to arachidonic acid at a concentration of 1mM, measured by LTA (Light Transmission Aggregometry).
7 DAYS.
Platelet aggregation response to various agonists
7 DAYS.
Platelet reactivity to various agonists such as ADP (Adenosine Diphosphate), TRAP (Thrombin receptor activating peptide), epinephrine and collagen will be assessed by LTA (Light Transmission Agregometry).
7 DAYS.
Serum levels of thromboxane B2
7 DAYS.
Serum levels of thromboxane B2, measured by immunoassay > 3.1 ng/ml will be considered as evidence of recovery of platelet function.
7 DAYS.

Who is running the study

Principal Investigator
G. M.
Prof. Guillaume Marquis-Gravel, Interventional Cardiologist, Associate Professor of Medicine
Montreal Heart Institute

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get diabetes mellitus, type 2 a year in the United States?

A high proportion of people over the age of 40 in the United States is at risk of developing diabetes mellitus, type 2. The American Diabetes Association expects that this population is [increasing in the future]. Diabetes mellitus, type 2 will then become the leading cause of diabetes morbidity and mortality in the United States.

Anonymous Patient Answer

What is diabetes mellitus, type 2?

Diabetes mellitus type 2 can be a debilitating condition that often leads to insulin resistance and results in high blood sugar. Diabetes mellitus type 2 can cause serious health complications.

Anonymous Patient Answer

What are common treatments for diabetes mellitus, type 2?

Treatment for patients affected by diabetes can be tailored to treat complications. Drug treatment is typically directed toward lowering blood sugar, while nonspecific diabetes management is targeted at managing comorbidities associated with diabetes. Medications for comorbid conditions, such as diabetes, are often indicated based on the presence of diabetes-associated comorbidities. Obesity, a more serious but treatable condition, is typically managed by caloric restriction and/or weight loss.

Anonymous Patient Answer

Can diabetes mellitus, type 2 be cured?

Diabetes, type 2 can be cured by good lifestyle choices. Many patients diagnosed with diabetes, type 2 will have significant health problems long after diagnosis due to poor glycemic control or poor disease management; however, many of these can be prevented by diet changes and exercise improvements.

Anonymous Patient Answer

What causes diabetes mellitus, type 2?

The exact cause of diabetes mellitus type 2 remains unclear, but factors that have been suggested include: a defective metabolism of body fat (abnormalities in the action of insulin), the development of pancreatic autoimmunity, or abnormal endocrine and metabolic functions. There are several theories regarding how diabetes mellitus type 2 causes chronic low insulin production. However, as little is actually known about this disease due to its rarity, progress in the diagnosis, and treatment of the condition are difficult. It is most likely that both inherited and acquired factors play some roles in the development of type 2 diabetes mellitus. The diagnosis usually comes after several years of high blood sugar and frequent checking with diabetic tests.

Anonymous Patient Answer

What are the signs of diabetes mellitus, type 2?

Signs of diabetes mellitus, type 2 include a decreased ability to see or think clearly, a loss of feeling in the feet, frequent urination and excessive thirst. As the two conditions develop, complications may be seen. Early signs of diabetes mellitus, type 2 may include weight loss, blurred vision, frequent urination, dry skin, frequent infections and low-grade fever.\n

Anonymous Patient Answer

Who should consider clinical trials for diabetes mellitus, type 2?

Current medical therapy for diabetes mellitus, type 2, appears optimal. However, many patients are not receiving the existing treatment, and a large proportion of patients have suboptimal glycemic control. Thus, more patients with type 2 diabetes could benefit from medical treatment.

Anonymous Patient Answer

Have there been other clinical trials involving aspirin 80 mg ec tab?

Results from a recent clinical trial of our current randomized clinical trial showed for both postoperative nausea and vomiting that oral aspirin 80 mg ec tab was not significantly different from placebo. Results from a recent clinical trial has implications for the use of aspirin as a postoperative analgesic.

Anonymous Patient Answer

What is aspirin 80 mg ec tab?

Ec tab aspirin 80 mg tablets are comparable to the capsule form of aspirin in terms of bioavailability and safety. In the treatment of hypercholesterolaemia, there appears to be little or no difference in the efficacy and safety of the capsule form and ec tab aspirin 80 mg tablets. The ec tab is therefore preferred to the capsule form for these indications.

Anonymous Patient Answer

Is aspirin 80 mg ec tab safe for people?

The ACC/AHA guideline issued is not always supported by evidence. Many physicians continue to practice aspirin 80 mg tablets ec to treat ischemic stroke. However, this practice is not supported by scientific evidence.

Anonymous Patient Answer

What are the common side effects of aspirin 80 mg ec tab?

It appears that the major side effects are gastrointestinal, whereas a few more minor ones are also present, but occur less often. The side effects recorded in our study (for example, dyspepsia, gastritis, colitis) are not necessarily due to aspirin and are not listed in the drug information sheets. However, as our study cannot refute a possible causality, one should read the information sheets thoroughly before taking aspirin. In case of gastrointestinal side effects after initiation of treatment with ASA, or of GI problems after treatment is discontinued, in particular during the first week of treatment, a re-evaluation of the effectiveness and mode of action of the specific treatment is required.

Anonymous Patient Answer

How serious can diabetes mellitus, type 2 be?

In terms of life expectancy, DM2 may be a [little less] serious condition than other conditions with significant morbidity and mortality, such as myocardial infarction and cancer. However, DM2 does confer a higher risk of mortality in the first 10 years following diagnosis. Additionally, with careful medical management, DM2 can improve long-term outcome, which makes its treatment less urgent.

Anonymous Patient Answer
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