Zyloprim

Hyperuricemia, Lesch-Nyhan Syndrome, Chemotherapy + 15 more
Treatment
12 FDA approvals
20 Active Studies for Zyloprim

What is Zyloprim

AllopurinolThe Generic name of this drug
Treatment SummaryGout is a painful condition caused by a buildup of uric acid crystals around the joints. It has been known since ancient times, and is mentioned in the biographies of several famous people. Allopurinol is a medication that is commonly used to treat gout. It works by reducing the levels of uric acid in the body and was first approved by the FDA in 1966. It is now made by multiple pharmaceutical companies.
Zyloprimis the brand name
image of different drug pills on a surface
Zyloprim Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyloprim
Allopurinol
1966
270

Approved as Treatment by the FDA

Allopurinol, also called Zyloprim, is approved by the FDA for 12 uses such as Chemotherapy and Symptomatic .
Chemotherapy
Symptomatic
Secondary gout
Malignant Lymphomas
Primary Gout
Hyperuricemia
Leukemias
Gouty Arthritis
Used to treat Gouty Arthritis in combination with Lesinurad
failed previous allopurinol monotherapy
Used to treat failed previous allopurinol monotherapy in combination with Lesinurad
Recurrent calcium oxalate calculi
female patients with daily uric acid excretion that exceeds 750 mg/day
male patients with daily uric acid excretion that exceeds 800 mg/day

Effectiveness

How Zyloprim Affects PatientsAllopurinol is a drug that helps to reduce the amount of uric acid in the body. This can help to relieve symptoms of gout, such as joint pain, swelling, inflammation, and stiffness.
How Zyloprim works in the bodyAllopurinol is a medication that works to reduce the symptoms of gout. It does this by blocking an enzyme called xanthine oxidase, which converts hypoxanthine to xanthine and then to uric acid. This blocks the body from making too much uric acid, which can cause gout. Allopurinol also increases the reutilization of hypoxanthine and xanthine for making nucleotides, further reducing the levels of uric acid. As a result, this medication lowers the levels of uric acid in the blood, preventing gout symptoms, and encourages the dissolution

When to interrupt dosage

The recommended dosage of Zyloprim is contingent upon the determined condition, such as Gout Flares, Leukemias and Cancer. The measure of dosage varies, depending on the technique of delivery (e.g. Injection, powder, lyophilized, for solution - Intravenous or Tablet, film coated - Oral) displayed in the table beneath.
Condition
Dosage
Administration
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chemotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Eczema
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lesch-Nyhan Syndrome
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Leukemias
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Gouty Arthritis
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Metabolic Diseases
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Symptomatic
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Malignant Lymphomas
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Gout Flares
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Primary Gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Recurrent calcium oxalate calculi
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
female patients with daily uric acid excretion that exceeds 750 mg/day
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Secondary gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
male patients with daily uric acid excretion that exceeds 800 mg/day
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Urinary Bladder Calculi (disorder)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
failed previous allopurinol monotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Zyloprim.
Common Zyloprim Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Major
The serum concentration of Didanosine can be increased when it is combined with Allopurinol.
Oteracil
Major
The therapeutic efficacy of Oteracil can be decreased when used in combination with Allopurinol.
Pegloticase
Major
The risk or severity of adverse effects can be increased when Allopurinol is combined with Pegloticase.
Abacavir
Minor
Allopurinol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Allopurinol may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Zyloprim Toxicity & Overdose RiskThe lowest toxic dose of allopurinol in rats is 10mg/kg and 78mg/kg in mice. Studies on pregnant rats and rabbits have found that taking up to twenty times the normal human dose (about 5 mg/kg per day) does not cause fertility problems or harm to the fetus. However, a study on pregnant mice found that giving 50 or 100mg/kg of allopurinol could result in dead fetuses and malformations in the surviving fetuses. Allopurinol and its metabolite oxipurinol have been found in breastmilk. Cytogenic studies have
image of a doctor in a lab doing drug, clinical research

Zyloprim Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyloprim?

560 active trials are in progress to analyze the potential of Zyloprim to ameliorate Kidney Disease, Chemotherapy-Related Issues and Metabolic Diseases.
Condition
Clinical Trials
Trial Phases
Eczema
27 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 4, Early Phase 1, Phase 3
Chronic Kidney Disease (CKD)
245 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Leukemias
0 Actively Recruiting
Secondary gout
0 Actively Recruiting
Hyperuricemia
2 Actively Recruiting
Phase 2, Phase 3
failed previous allopurinol monotherapy
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Gouty Arthritis
1 Actively Recruiting
Phase 2, Phase 3
Urinary Bladder Calculi (disorder)
0 Actively Recruiting
Primary Gout
0 Actively Recruiting
Malignant Lymphomas
3 Actively Recruiting
Phase 1
Recurrent calcium oxalate calculi
0 Actively Recruiting
Metabolic Diseases
4 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Lesch-Nyhan Syndrome
0 Actively Recruiting
male patients with daily uric acid excretion that exceeds 800 mg/day
0 Actively Recruiting
Chemotherapy
2 Actively Recruiting
Not Applicable
female patients with daily uric acid excretion that exceeds 750 mg/day
0 Actively Recruiting
Symptomatic
0 Actively Recruiting

Zyloprim Reviews: What are patients saying about Zyloprim?

5Patient Review
10/13/2008
Zyloprim for High Amount of Uric Acid in the Blood
Allopurinol has been fantastic in keeping my uric acid levels down. I haven't had a gout attack in years!
5Patient Review
9/5/2009
Zyloprim for Gout
I've been taking this medication for around 15 years to help with my gout, and it's always worked well. However, I'm now experiencing numbness in my fingers and toes, which is making everyday tasks more difficult.
5Patient Review
1/2/2009
Zyloprim for Uric Acid Kidney Stones
I was content with this medication, until I found out that the FDA is approving a new drug and discontinuing this one. What's the reasoning behind this sudden change?
5Patient Review
7/18/2009
Zyloprim for Gout
I'm so thankful for this pill because it always helps me when I get gout. It's really painful, and the brand name medication always makes it worse.
5Patient Review
4/16/2009
Zyloprim for Gout
Allopurinol has been a life-saver for me. Gout used to be a constant problem, but since I've been taking this medication, I haven't had any issues at all.
5Patient Review
10/20/2008
Zyloprim for Gout
It's been over a decade since I've had any problems with gout, and before that it was a regular occurrence. This treatment has been amazing in preventing pain.
5Patient Review
4/2/2010
Zyloprim for Inflammation of the Joints due to Gout
This drug was a complete game-changer for me. The pain I was experiencing before hand was absolutely unbearable and caused me to miss work frequently. After being on this medication for six years, I experienced zero negative side effects. Not only that, but the medication allowed me to get rid of my crutches entirely!
5Patient Review
10/14/2011
Zyloprim for Gout
I've been on allopurinol for five years now and it's really helped me. Recently, though, I was diagnosed with renal cell carcinoma. Has anyone else had a similar experience?
5Patient Review
10/26/2008
Zyloprim for Gout
I've only been on this drug for three months, but I'm already really pleased with it.
4.3Patient Review
12/13/2013
Zyloprim for Gout
This drug was effective in treating my gout and I saw results within a few days. However, I started experiencing tightness and tingling in my feet which has progressed over time. I went to see several different doctors but they were unable to diagnose the problem. After doing some research, I discovered that this could be a side effect of the allopurinol so I stopped taking it and the symptoms have gone away.
4Patient Review
11/27/2007
Zyloprim for Gout
Zyloprim is a well-known and effective drug for treating gout. It's affordable, which is great.
3.7Patient Review
7/27/2009
Zyloprim for High Amount of Uric Acid in the Blood
The medication caused me to feel nauseous for most of the day.
3.3Patient Review
3/8/2012
Zyloprim for Inflammation of the Joints due to Gout
I found that this medication made me drowsy when taken with Sulindac 200mg. I was using it to treat a swollen knee and gout.
2.3Patient Review
9/3/2021
Zyloprim for Inflammation of the Joints due to Gout
I have been taking zyloprim for a long time, but now that they've changed the color of the tablet to pink, I'm experiencing severe pain in my legs and shoulders. I can only move slowly and with great difficulty.
2Patient Review
5/27/2011
Zyloprim for Gout
I have been taking allopurinol for about four months now and, during that time, I have experienced the most severe and longest-lasting attacks. Prior to taking the drug, my attacks occurred about once every two months and were usually a result of dietary slip-ups; however, since starting this medication, I have had pain for weeks at a time despite following my diet closely. Given the number of positive reviews for this treatment, I am surprised that it has not worked better for me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zyloprim

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug Zyloprim used for?

"Allopurinol is a medication used to treat gout, certain types of kidney stones, and to prevent increased uric acid levels in cancer patients undergoing chemotherapy. Increased uric acid levels in these patients is caused by the release of uric acid from the cancer cells that are dying."

Answered by AI

Is Zyloprim the same as allopurinol?

"Allopurinol decreases the amount of uric acid produced by the body, which can prevent gout and kidney issues. It is sold under the brand names Zyloprim and Aloprim."

Answered by AI

When should Zyloprim be given?

"The recommended dosage for Allopurinol is one tablet taken once daily, preferably after a meal. To help your body eliminate uric acid, it is important to drink plenty of water throughout the day. Allopurinol should be taken with a full glass of water."

Answered by AI

What are the side effects of Zyloprim?

"drowsiness, headache, diarrhea, vomiting, stomach discomfort, changes in your sense of taste, muscle pain."

Answered by AI

Clinical Trials for Zyloprim

Have you considered Zyloprim clinical trials? We made a collection of clinical trials featuring Zyloprim, we think they might fit your search criteria.
Have you considered Zyloprim clinical trials? We made a collection of clinical trials featuring Zyloprim, we think they might fit your search criteria.
Have you considered Zyloprim clinical trials? We made a collection of clinical trials featuring Zyloprim, we think they might fit your search criteria.