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What is Zyloprim
AllopurinolThe Generic name of this drug
Treatment SummaryGout is a painful condition caused by a buildup of uric acid crystals around the joints. It has been known since ancient times, and is mentioned in the biographies of several famous people. Allopurinol is a medication that is commonly used to treat gout. It works by reducing the levels of uric acid in the body and was first approved by the FDA in 1966. It is now made by multiple pharmaceutical companies.
Zyloprimis the brand name
Zyloprim Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyloprim
Allopurinol
1966
270
Approved as Treatment by the FDA
Allopurinol, also called Zyloprim, is approved by the FDA for 16 uses such as Kidney Calculi and female patients with daily uric acid excretion that exceeds 750 mg/day .Kidney Calculi
female patients with daily uric acid excretion that exceeds 750 mg/day
Cancer
Hyperuricemia
Leukemias
Malignant Lymphomas
Arthritis, Gouty
Used to treat Gouty Arthritis in combination with Lesinurad
failed previous allopurinol monotherapy
Used to treat failed previous allopurinol monotherapy in combination with Lesinurad
Hyperuricemia
Hyperuricemia
Chemotherapy
Lymphoma, Non-Hodgkin
Leukemia
Symptomatic
Secondary gout
Primary Gout
Effectiveness
How Zyloprim Affects PatientsAllopurinol is a drug that helps to reduce the amount of uric acid in the body. This can help to relieve symptoms of gout, such as joint pain, swelling, inflammation, and stiffness.
How Zyloprim works in the bodyAllopurinol is a medication that works to reduce the symptoms of gout. It does this by blocking an enzyme called xanthine oxidase, which converts hypoxanthine to xanthine and then to uric acid. This blocks the body from making too much uric acid, which can cause gout. Allopurinol also increases the reutilization of hypoxanthine and xanthine for making nucleotides, further reducing the levels of uric acid. As a result, this medication lowers the levels of uric acid in the blood, preventing gout symptoms, and encourages the dissolution
When to interrupt dosage
The recommended dosage of Zyloprim is contingent upon the determined condition, such as Gout Flares, Leukemias and Cancer. The measure of dosage varies, depending on the technique of delivery (e.g. Injection, powder, lyophilized, for solution - Intravenous or Tablet, film coated - Oral) displayed in the table beneath.Condition
Dosage
Administration
Symptomatic
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chemotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Metabolic Diseases
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Gout Flares
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Eczema
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Leukemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Primary Gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lesch-Nyhan Syndrome
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Arthritis, Gouty
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Kidney Calculi
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
female patients with daily uric acid excretion that exceeds 750 mg/day
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
failed previous allopurinol monotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Urinary Bladder Calculi (disorder)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lymphoma, Non-Hodgkin
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Secondary gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Zyloprim.Common Zyloprim Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Major
The serum concentration of Didanosine can be increased when it is combined with Allopurinol.
Oteracil
Major
The therapeutic efficacy of Oteracil can be decreased when used in combination with Allopurinol.
Pegloticase
Major
The risk or severity of adverse effects can be increased when Allopurinol is combined with Pegloticase.
Abacavir
Minor
Allopurinol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Allopurinol may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Zyloprim Toxicity & Overdose RiskThe lowest toxic dose of allopurinol in rats is 10mg/kg and 78mg/kg in mice. Studies on pregnant rats and rabbits have found that taking up to twenty times the normal human dose (about 5 mg/kg per day) does not cause fertility problems or harm to the fetus. However, a study on pregnant mice found that giving 50 or 100mg/kg of allopurinol could result in dead fetuses and malformations in the surviving fetuses. Allopurinol and its metabolite oxipurinol have been found in breastmilk. Cytogenic studies have
Zyloprim Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyloprim?
560 active trials are in progress to analyze the potential of Zyloprim to ameliorate Kidney Disease, Chemotherapy-Related Issues and Metabolic Diseases.Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
26 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Secondary gout
0 Actively Recruiting
Lymphoma, Non-Hodgkin
2 Actively Recruiting
Phase 1
Leukemia
0 Actively Recruiting
failed previous allopurinol monotherapy
0 Actively Recruiting
Eczema
10 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 3
Lesch-Nyhan Syndrome
0 Actively Recruiting
Arthritis, Gouty
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Hyperuricemia
0 Actively Recruiting
Chemotherapy
4 Actively Recruiting
Phase 1, Phase 3, Not Applicable
female patients with daily uric acid excretion that exceeds 750 mg/day
0 Actively Recruiting
Kidney Calculi
0 Actively Recruiting
Metabolic Diseases
2 Actively Recruiting
Not Applicable
Hyperuricemia
4 Actively Recruiting
Phase 3, Phase 1
Urinary Bladder Calculi (disorder)
0 Actively Recruiting
Primary Gout
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Symptomatic
0 Actively Recruiting
Zyloprim Reviews: What are patients saying about Zyloprim?
5Patient Review
10/13/2008 Allopurinol has been fantastic in keeping my uric acid levels down. I haven't had a gout attack in years!
5Patient Review
9/5/2009 I've been taking this medication for around 15 years to help with my gout, and it's always worked well. However, I'm now experiencing numbness in my fingers and toes, which is making everyday tasks more difficult.
5Patient Review
1/2/2009 I was content with this medication, until I found out that the FDA is approving a new drug and discontinuing this one. What's the reasoning behind this sudden change?
5Patient Review
7/18/2009 I'm so thankful for this pill because it always helps me when I get gout. It's really painful, and the brand name medication always makes it worse.
5Patient Review
4/16/2009 Allopurinol has been a life-saver for me. Gout used to be a constant problem, but since I've been taking this medication, I haven't had any issues at all.
Patient Q&A Section about zyloprim
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Zyloprim used for?
"Allopurinol is a medication used to treat gout, certain types of kidney stones, and to prevent increased uric acid levels in cancer patients undergoing chemotherapy. Increased uric acid levels in these patients is caused by the release of uric acid from the cancer cells that are dying."
Answered by AI
Is Zyloprim the same as allopurinol?
"Allopurinol decreases the amount of uric acid produced by the body, which can prevent gout and kidney issues. It is sold under the brand names Zyloprim and Aloprim."
Answered by AI
When should Zyloprim be given?
"The recommended dosage for Allopurinol is one tablet taken once daily, preferably after a meal. To help your body eliminate uric acid, it is important to drink plenty of water throughout the day. Allopurinol should be taken with a full glass of water."
Answered by AI
What are the side effects of Zyloprim?
"drowsiness, headache, diarrhea, vomiting, stomach discomfort, changes in your sense of taste, muscle pain."
Answered by AI
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