Zyban

Smoke, Reducing diet, Seasonal Affective Disorder + 5 more
Treatment
4 FDA approvals
20 Active Studies for Zyban

What is Zyban

BupropionThe Generic name of this drug
Treatment SummaryBupropion (also known as Wellbutrin®) is a medication used to treat depression, seasonal affective disorder, and to help people quit smoking. It works by preventing the uptake of norepinephrine and dopamine, two important neurotransmitters. It is an atypical antidepressant since it does not have the same effects as other mood medications. Bupropion is less likely to cause sexual side effects, sedation, or weight gain compared to other antidepressants. When used to help people quit smoking, bupropion works by targeting the reward pathways associated with nicotine. It can also be used as an add-on
Wellbutrinis the brand name
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Zyban Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Wellbutrin
Bupropion
1986
741

Approved as Treatment by the FDA

Bupropion, also known as Wellbutrin, is approved by the FDA for 4 uses which include Obesity and Smoke .
Obesity
Used to treat Obesity in combination with Naltrexone
Smoke
Smoking Cessation
Depression

Effectiveness

How Zyban Affects PatientsBupropion is a drug that is not related to other known antidepressants. It works by blocking the uptake of norepinephrine and dopamine, but not serotonin. It has been found to increase movement and alertness, and could potentially lead to abuse. Taking bupropion can lower the seizure threshold, meaning it should not be taken if you have a pre-existing seizure condition. In addition, it can raise blood pressure, so people with hypertension should be careful if taking this drug. In clinical trials, the mean increase in systolic blood pressure was 1.3 mmHg.
How Zyban works in the bodyBupropion is an antidepressant that works differently than other common antidepressants. It does this by blocking enzymes that would normally take norepinephrine and dopamine away from the brain. This allows these neurotransmitters to stay active in the brain for longer, leading to antidepressant effects. Bupropion is also used to help people quit smoking and to aid in weight loss. In these cases, it works by blocking nicotine receptors and altering reward pathways in the brain that are associated with food intake.

When to interrupt dosage

The proposed measure of Zyban is contingent upon the diagnosed condition, including Depressive Bipolar Disorder, Depression and Disease. The amount also depends on the technique of delivery (e.g. Tablet, extended release or Tablet, film coated, extended release) featured in the table below.
Condition
Dosage
Administration
Reducing diet
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Obesity
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Seasonal Affective Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Mood Disorders
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoking Cessation
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Attention Deficit Hyperactivity Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoke
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Depression
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Warnings

Zyban Contraindications
Condition
Risk Level
Notes
Bulimia Nervosa
Do Not Combine
ethanol
Do Not Combine
Hypertensive disease
Do Not Combine
Anorexia Nervosa
Do Not Combine
abrupt cessation of barbiturates
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Epilepsy
Do Not Combine
abrupt cessation of antiepileptic drugs
Do Not Combine
Benzodiazepines
Do Not Combine
Pulse Frequency
Do Not Combine
Anorexia Nervosa
Do Not Combine
Anorexia Nervosa
Do Not Combine
There are 20 known major drug interactions with Zyban.
Common Zyban Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Bupropion.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Bupropion.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Bupropion.
Zyban Toxicity & Overdose RiskOverdosing on Dilantin can cause seizures, hallucinations, passing out, a rapid heartbeat, and even heart failure.
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Zyban Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyban?

490 active clinical trials are examining the potential of Zyban to treat Attention Deficit Hyperactivity Disorder, Depression and Smoking Cessation.
Condition
Clinical Trials
Trial Phases
Smoking Cessation
95 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1
Depression
194 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Obesity
56 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3
Attention Deficit Hyperactivity Disorder
65 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Mood Disorders
14 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1, Phase 3
Seasonal Affective Disorder
0 Actively Recruiting
Smoke
0 Actively Recruiting
Reducing diet
0 Actively Recruiting

Zyban Reviews: What are patients saying about Zyban?

5Patient Review
8/2/2014
Zyban for Stop Smoking
I smoked for 15 years before trying this medication to quit. Just five days after starting the regimen, I was able to put down cigarettes for good. The first few days were tough in that I would have sudden cravings; however, these only lasted a few seconds and mints helped me get through them. By the fourth day, I felt fine being around smokers without any sort of side effects from the drug.
5Patient Review
7/29/2018
Zyban for Nicotine Addiction
I had tried to quit smoking many times before, but Zyban was the first treatment that actually worked for me. I've been smoke-free for over 12 years now.
5Patient Review
6/28/2015
Zyban for Stop Smoking
After 46 years of smoking, I was finally able to quit with this treatment. It's been 50 days now and I'm feeling great. The cravings are gone and I've saved so much money.
5Patient Review
7/3/2015
Zyban for Stop Smoking
I've been taking zyban for a week now, and I still feel sick in the mornings. But I can say that I don't think about smoking cigarettes anymore. I'm hopeful that this time I will be able to quit for good.
5Patient Review
10/16/2014
Zyban for Stop Smoking
I had been smoking for thirty years and had failed to quit many times before. This treatment really helped me finally kick the habit.
View All Reviews
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Patient Q&A Section about zyban

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What's the side effects of Zyban?

"Side effects such as dizziness, drowsiness, nausea, diarrhea, fatigue, constipation, blurred vision, increased sweating, strange taste in mouth, or stomach pain may occur. If any of these effects persist or worsen, you should notify your doctor or pharmacist."

Answered by AI

Is Zyban and Wellbutrin the same thing?

"Zyban and Wellbutrin are both drugs that come from the antidepressant bupropion. The major difference between the two drugs is their purpose. Zyban is used to help people quit smoking cigarettes, while Wellbutrin is used to manage major depression and seasonal affective disorder."

Answered by AI

Can you smoke while taking Zyban?

"The benefits of taking Zyban include its easy administration and the lack of nicotine which prevents toxicity."

Answered by AI

What is Zyban prescribed for?

"ZYBAN is a medicine that your doctor prescribes to help you stop smoking. ZYBAN is different than nicotine replacement treatments; instead, it is thought to act in the brain to decrease cravings. For many patients, ZYBAN reduces withdrawal symptoms and the urge to smoke."

Answered by AI

Clinical Trials for Zyban

Have you considered Zyban clinical trials? We made a collection of clinical trials featuring Zyban, we think they might fit your search criteria.
Have you considered Zyban clinical trials? We made a collection of clinical trials featuring Zyban, we think they might fit your search criteria.
Have you considered Zyban clinical trials? We made a collection of clinical trials featuring Zyban, we think they might fit your search criteria.
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