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What is Zelapar
SelegilineThe Generic name of this drug
Treatment SummaryDeprenyl is a medication used to treat Parkinson’s Disease. It works by blocking an enzyme in the brain that breaks down certain chemicals that are important for nerve function. Deprenyl can slow down the progression of the disease, delay the need for levodopa therapy, and be taken in combination with levodopa.
Eldeprylis the brand name
Zelapar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Eldepryl
Selegiline
1989
29
Approved as Treatment by the FDA
Selegiline, commonly known as Eldepryl, is approved by the FDA for 1 uses like Parkinson's Disease .Parkinson's Disease
Used in combination with other therapies
Effectiveness
How Zelapar Affects PatientsDopamine is a natural chemical found in the body. When dopamine breaks down too quickly, it can lead to the symptoms of Parkinson's disease. Selegiline works by blocking the enzyme (MAO-B) that breaks down dopamine, so the dopamine can stay in the brain longer. It may also help make sure dopamine is properly released from nerve cells.
How Zelapar works in the bodySelegiline is used to treat Parkinson's disease by blocking an enzyme called monoamine oxidase type B (MAO-B). This enzyme breaks down dopamine, which is a chemical involved in sending signals between nerve cells in the brain. Blocking MAO-B helps increase dopamine levels, and thus helps improve symptoms of Parkinson's. At higher doses, selegiline can also block another enzyme called monozmine oxidase type A (MAO-A), which is used to treat depression.
When to interrupt dosage
The proposed measure of Zelapar is determined by the specified condition, such as Attention Deficit Hyperactivity Disorder, Depression and Parkinson's Disease. The amount of dosage varies, conforming to the technique of delivery (e.g. Patch or Oral) featured in the table underneath.Condition
Dosage
Administration
Parkinson's Disease
, 5.0 mg, 1.25 mg, 0.6 mg/hour, 0.9 mg/hour, 1.2 mg/hour
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Patch, Patch - Transdermal, Transdermal
Depression
, 5.0 mg, 1.25 mg, 0.6 mg/hour, 0.9 mg/hour, 1.2 mg/hour
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Patch, Patch - Transdermal, Transdermal
Attention Deficit Hyperactivity Disorder
, 5.0 mg, 1.25 mg, 0.6 mg/hour, 0.9 mg/hour, 1.2 mg/hour
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Patch, Patch - Transdermal, Transdermal
Warnings
Zelapar ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
contraindicated drugs
Do Not Combine
Pulse Frequency
Do Not Combine
Pheochromocytomas
Do Not Combine
Pulse Frequency
Do Not Combine
Common Zelapar Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
Selegiline may increase the hypertensive activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Selegiline.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Selegiline is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Alaproclate
Major
Selegiline may increase the serotonergic activities of Alaproclate.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Selegiline.
Zelapar Toxicity & Overdose RiskThe amount of the drug needed to be toxic to rats when injected was found to be 63 mg/kg.
Zelapar Novel Uses: Which Conditions Have a Clinical Trial Featuring Zelapar?
308 active clinical trials are currently underway to assess the potency of Zelapar in addressing Depression, Parkinson's Disease and Attention Deficit Hyperactivity Disorder.Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Attention Deficit Hyperactivity Disorder
71 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Depression
199 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Zelapar Reviews: What are patients saying about Zelapar?
4.3Patient Review
12/11/2007 Zelapar is highly effective with no negative side effects that I experienced. The only downside is the cost.
4Patient Review
2/6/2009 This medication provides the boost I need until my other medications can take effect. I was able to get it at a reduced cost by using a rebate, but I'm not sure if that's still an option.
4Patient Review
3/19/2008 My blood pressure often spikes, so I can't take painkillers like Advil.
Patient Q&A Section about zelapar
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Zelapar used for?
"Zelapar is a prescription medicine used to treat the symptoms of [Parkinson disease](https://www.withpower.com/clinical-trials/parkinson-disease). Zelapar may be used alone or with other medications. Zelapar inhibits the monoamine oxidase type B enzyme, which is involved in the breakdown of dopamine. This action helps to increase dopamine levels in the brain, which are thought to be deficient in people with Parkinson disease."
Answered by AI
How do you take Zelapar?
"To use Zelapar, dissolve the tablet on your tongue once a day, either in the morning or as directed by your doctor. Do not swallow the tablet or the dissolved medication with saliva or water; it should be absorbed into your mouth lining."
Answered by AI
What is the brand name for selegiline?
"Selegiline is a medication used to treat depression and dementia. The medication comes in two forms, Eldepryl and Zelapar, and is taken by mouth."
Answered by AI
Where does selegiline act?
"Selegiline prevents monoamine oxidase from breaking down monoamine neurotransmitters, resulting in increased levels of these chemicals in the brain. At typical doses used to treat Parkinson's disease, selegiline selectively and irreversibly prevents monoamine oxidase B from breaking down dopamine, resulting in increased levels of this neurotransmitter in the brain."
Answered by AI