What is Vaseretic
EnalaprilThe Generic name of this drug
Treatment SummaryEnalapril is a medication used to treat high blood pressure. It belongs to a class of drugs called ACE inhibitors, which work by blocking the production of a hormone called angiotensin II, resulting in lower blood pressure. Enalapril is also used to treat heart failure and other conditions related to the heart. The drug is sold under the brand name Vasotec and is available as an oral tablet or an intravenous injection. It was first approved by the FDA in 1985 and is sometimes found in a combination product with hydrochlorothiazide, another drug used to treat high blood pressure.
Enalapril Maleateis the brand name
Vaseretic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Enalapril Maleate
Enalapril
1985
352
Approved as Treatment by the FDA
Enalapril, also known as Enalapril Maleate, is approved by the FDA for 3 uses including asymptomatic Left ventricular dysfunction and Symptomatic Congestive Heart Failure .asymptomatic Left ventricular dysfunction
Helps manage asymptomatic Left ventricular dysfunction
Symptomatic Congestive Heart Failure
Helps manage Symptomatic Congestive Heart Failure
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Vaseretic Affects PatientsEnalapril is a medication used to lower blood pressure. It works by reducing the amount of fluid in the body, reducing the amount of resistance in the blood vessels, and preventing the heart rate from increasing. It can take several weeks of regular use to see a full effect. Enalapril can improve both preload and afterload in patients with severe congestive heart failure, as well as reduce left ventricular mass without affecting cardiac function or myocardial perfusion during exercise. It does not usually cause side effects like low potassium levels, high blood sugar, high uric acid, or high cholesterol. In the kidneys
How Vaseretic works in the bodyEnalapril works on the body's renin-angiotensin-aldosterone system. It inhibits an enzyme called ACE, which reduces the production of a hormone called angiotensin II. This hormone causes blood vessels to narrow and increases salt retention in the kidneys. With less angiotensin II, the blood vessels widen, which lowers blood pressure. Enalapril might also increase levels of bradykinin, another hormone, which could help lower blood pressure. However, this hasn't been proven yet.
When to interrupt dosage
The measure of Vaseretic is contingent upon the diagnosed issue, including asymptomatic Left ventricular dysfunction, blood pressure inadequately managed with monotherapy and Hypertensive disease. The dosage is contingent upon the delivery technique noted in the table below.Condition
Dosage
Administration
asymptomatic Left ventricular dysfunction
, 16.0 mg, 2.0 mg, 8.0 mg, 4.0 mg, 32.0 mg, 1.0 mg/mL, 5.0 mg, 5000.0 mg, 2.5 mg, 10.0 mg, 20.0 mg
, Tablet, soluble, Oral, Tablet - Oral, Tablet, extended release - Oral, Tablet, Solution - Oral, Solution, Tablet, soluble - Oral, Tablet, extended release
Symptomatic Congestive Heart Failure
, 16.0 mg, 2.0 mg, 8.0 mg, 4.0 mg, 32.0 mg, 1.0 mg/mL, 5.0 mg, 5000.0 mg, 2.5 mg, 10.0 mg, 20.0 mg
, Tablet, soluble, Oral, Tablet - Oral, Tablet, extended release - Oral, Tablet, Solution - Oral, Solution, Tablet, soluble - Oral, Tablet, extended release
blood pressure inadequately controlled with monotherapy
, 16.0 mg, 2.0 mg, 8.0 mg, 4.0 mg, 32.0 mg, 1.0 mg/mL, 5.0 mg, 5000.0 mg, 2.5 mg, 10.0 mg, 20.0 mg
, Tablet, soluble, Oral, Tablet - Oral, Tablet, extended release - Oral, Tablet, Solution - Oral, Solution, Tablet, soluble - Oral, Tablet, extended release
Diabetic Nephropathy
, 16.0 mg, 2.0 mg, 8.0 mg, 4.0 mg, 32.0 mg, 1.0 mg/mL, 5.0 mg, 5000.0 mg, 2.5 mg, 10.0 mg, 20.0 mg
, Tablet, soluble, Oral, Tablet - Oral, Tablet, extended release - Oral, Tablet, Solution - Oral, Solution, Tablet, soluble - Oral, Tablet, extended release
Hypertensive disease
, 16.0 mg, 2.0 mg, 8.0 mg, 4.0 mg, 32.0 mg, 1.0 mg/mL, 5.0 mg, 5000.0 mg, 2.5 mg, 10.0 mg, 20.0 mg
, Tablet, soluble, Oral, Tablet - Oral, Tablet, extended release - Oral, Tablet, Solution - Oral, Solution, Tablet, soluble - Oral, Tablet, extended release
Warnings
Vaseretic has six contraindications, so it should not be administered when encountering the issues specified in the following table.Vaseretic ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Angioedema
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Common Vaseretic Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Enalapril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Enalapril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Enalapril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Enalapril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Enalapril.
Vaseretic Toxicity & Overdose RiskEnalapril is toxic in large doses. In rats, the oral LD50 is 2973 mg/kg and lethality was observed with single doses greater than 1000 mg/kg in mice and 1775 mg/kg in rats. Overdosing on enalapril can cause marked low blood pressure, fatigue, dizziness, stupor, and a cough. To treat an overdose, intravenous saline may be administered, and hemodialysis can be used to remove enalapril from the bloodstream.In rabbits, doses of 1 mg/kg/day or more of enalapril
Vaseretic Novel Uses: Which Conditions Have a Clinical Trial Featuring Vaseretic?
19 active studies are being conducted to assess the potential of Vaseretic to mitigate Hypertensive disease, inadequately controlled blood pressure by monotherapy and asymptomatic Left ventricular dysfunction.Condition
Clinical Trials
Trial Phases
Symptomatic Congestive Heart Failure
0 Actively Recruiting
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
asymptomatic Left ventricular dysfunction
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Hypertensive disease
22 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4
Vaseretic Reviews: What are patients saying about Vaseretic?
5Patient Review
4/3/2017 Vaseretic is highly effective for treating high blood pressure.
5Patient Review
1/1/20105Patient Review
4/3/20102Patient Review
4/28/2010 My doctor changed my blood pressure medication, and in my opinion, this one is more effective.
Patient Q&A Section about vaseretic
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is enalapril tablets used for?
"Enalapril is a medicine used to treat high blood pressure."
Answered by AI
Does enalapril make you urinate more?
"If you're taking Vaseretic (enalapril / hydrochlorothiazide), you may need to go to the bathroom more often. It's best to take the medication in the morning or afternoon."
Answered by AI
What are the side effects of enalapril?
"If you experience any of the following symptoms, you should see a doctor: feeling lightheaded or like you might pass out; chest pain; yellowing of the skin or eyes (jaundice); little or no urination; fever, chills, or sore throat; or high potassium levels (nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement)."
Answered by AI
What is vaseretic used for?
"Hydrochlorothiazide belongs to a class of drugs known as thiazide diuretics ("water pills").
The medication is used to lower high blood pressure to help prevent strokes, heart attacks, and kidney problems. The medication contains two drugs, enalapril and hydrochlorothiazide. Enalapril belongs to a class of drugs known as ACE inhibitors while hydrochlorothiazide belongs to a class of drugs known as thiazide diuretics."
Answered by AI