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What is Trifluridine
TrifluridineThe Generic name of this drug
Treatment SummaryTrifluridine is an antiviral medicine used to treat eye infections caused by the herpes simplex virus 1 and 2. It can also be combined with another drug called tipiracil to treat metastatic colorectal cancer in adults. Trifluridine works by stopping the replication of cancer cells, which can help slow down the growth of tumors.
Viropticis the brand name
Trifluridine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viroptic
Trifluridine
1980
7
Approved as Treatment by the FDA
Trifluridine, commonly known as Viroptic, is approved by the FDA for 4 uses which include previously treated with anti-VEGF and RAS wild-type with previous of anti-EGFR therapy .previously treated with anti-VEGF
Used to treat previously treated with anti-VEGF in combination with Tipiracil
RAS wild-type with previous of anti-EGFR therapy
Used to treat RAS wild-type with previous of anti-EGFR therapy in combination with Tipiracil
oxaliplatin
Used to treat previous treatment with fluoropyrimidine, oxaliplatin and irinotecan in combination with Tipiracil
Colorectal Cancer
Used to treat Metastatic Colorectal Cancer (CRC) in combination with Tipiracil
Effectiveness
How Trifluridine Affects PatientsTrifluridine is an antiviral medication used to treat herpes simplex virus, types 1 and 2, vacciniavirus, and some strains of adenovirus that can cause eye issues. In clinical trials, it has been shown to be effective in treating dendritic ulcers in patients unresponsive to other similar medications. In nonclinical studies, it has been shown to have anti-tumour activity against colorectal cancer cells. It also has the potential to increase progression-free survival, overall response rate, and disease control rate when administered in combination with other medications for previously treated metastatic colore
How Trifluridine works in the bodyTrifluridine works to stop the replication of viruses and cancer cells. It binds to DNA strands inside of the cell and causes mutations that make it difficult for the virus or cell to reproduce. Trifluridine also interferes with an enzyme called thymidylate synthetase, which helps cells produce DNA. Inhibiting this enzyme makes it harder for cancer cells to reproduce. Trifluridine works in combination with another drug called tipiracil, which increases its effectiveness in the body.
When to interrupt dosage
The prescribed dosage of Trifluridine relies upon the diagnosed condition, including Pharmacotherapy, prophylaxis of vaccinia contamination in the cornea and conjunctiva and Eyelid construction. The amount likewise changes as per the technique of delivery (e.g. Tablet - Oral or Oral) exhibited in the table underneath.Condition
Dosage
Administration
prophylaxis of vaccinia infection in the cornea and conjunctiva
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
smallpox vaccinations
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Communicable Diseases
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Eyelid structure
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
herpesvirus 2, human
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
vaccinia infection in the cornea and conjunctiva
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Herpes Simplex Infections
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Blepharitis
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
disease progression after 2 or more HER2/neu-targeted therapy
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
oxaliplatin
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Metastatic Gastric Adenocarcinoma
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Metastatic Gastroesophageal Junction Adenocarcinoma
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
at least two prior systemic chemotherapy regimens
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
RAS wild-type with previous of anti-EGFR therapy
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
previously treated with anti-VEGF
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Pharmacotherapy
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Colorectal Cancer
, 10.0 mg/mL, 1.0 %, 20.0 mg, 15.0 mg
Ophthalmic, , Solution, Solution - Ophthalmic, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Trifluridine.Common Trifluridine Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Trifluridine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Trifluridine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Trifluridine is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Trifluridine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Trifluridine is combined with Acteoside.
Trifluridine Toxicity & Overdose RiskThe maximum toxic dose of Lonsurf, trifluridine in combination with tipiracil, when taken intravenously in rats is 2946 mg/kg. When taken orally in rats and mice it is greater than 4379mg/kg. It is unlikely that an overdose can occur through ocular instillation. The highest dose of Lonsurf taken in clinical studies was 180 mg/m^2 per day. The main consequence of an overdose is bone marrow suppression, and there is no known antidote. If an overdose occurs, medical treatment should be used to address the symptoms and prevent any further complications. Animal
Trifluridine Novel Uses: Which Conditions Have a Clinical Trial Featuring Trifluridine?
49 active clinical trials are currently underway to assess the potential of Trifluridine to provide Pharmacotherapy, prophylaxis against vaccinia infection in the cornea and conjunctiva and Communicable Disease prevention.Condition
Clinical Trials
Trial Phases
Colorectal Cancer
46 Actively Recruiting
Phase 3, Phase 2, Phase 1, Not Applicable
Blepharitis
0 Actively Recruiting
vaccinia infection in the cornea and conjunctiva
0 Actively Recruiting
RAS wild-type with previous of anti-EGFR therapy
0 Actively Recruiting
oxaliplatin
0 Actively Recruiting
Metastatic Gastroesophageal Junction Adenocarcinoma
19 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Early Phase 1, Phase 3
herpesvirus 2, human
0 Actively Recruiting
previously treated with anti-VEGF
0 Actively Recruiting
prophylaxis of vaccinia infection in the cornea and conjunctiva
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
smallpox vaccinations
0 Actively Recruiting
disease progression after 2 or more HER2/neu-targeted therapy
0 Actively Recruiting
at least two prior systemic chemotherapy regimens
0 Actively Recruiting
Eyelid structure
0 Actively Recruiting
Herpes Simplex Infections
0 Actively Recruiting
Metastatic Gastric Adenocarcinoma
9 Actively Recruiting
Phase 2, Phase 1, Phase 3, Early Phase 1
Pharmacotherapy
0 Actively Recruiting
Trifluridine Reviews: What are patients saying about Trifluridine?
5Patient Review
10/24/2008 These drops immediately started working and helped me recover from my eye infection.
5Patient Review
8/5/2011 Trifluridine really helped to heal my cornea. I took it one day at a time, and while it didn't happen overnight, it was definitely worth the wait. Being able to see is so important to me, and this treatment helped make that possible again.
5Patient Review
2/10/2010 I've had the herpes virus since I was an infant. It's usually brought on by mold in the air, for example when the temperature changes from cold to warm or vice versa. I'm 67 now and had a flare-up in 2009.
5Patient Review
7/15/2009 I saw a significant reduction in pain after only three applications of this treatment. I'm so thankful that this exists to help people with painful conditions.
Patient Q&A Section about trifluridine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take for trifluridine eye drops to work?
"How long does it take for trifluridine (Viroptic) to work? It usually takes 6 to 12 days for ulcers to heal when using trifluridine (Viroptic), but this depends on the severity of the damage. Follow-up appointments are important to ensure that the infection is being properly treated."
Answered by AI
What are the side effects of trifluridine?
"If you experience blurred vision or any other changes in your vision, dryness in your eyes, irritation, itching, redness, swelling, or any other sign of irritation after using this medication, please contact your doctor."
Answered by AI
Is trifluridine a steroid?
"Trifluridine is an antiviral medicine that prevents viruses from causing infections."
Answered by AI
What is trifluridine used for?
"Trifluridine eye Drops are used to treat viral infections of the eye."
Answered by AI