Tretinoin

cutaneous lesions, Eczema, Eczema + 2 more

Treatment

0 Active Studies for Tretinoin

What is Tretinoin

Alitretinoin

The Generic name of this drug

Treatment Summary

Tretinoin, also known as retinoic acid, is a drug used to regulate gene expression in development and growth, as well as in cancer. It is derived from vitamin A and is necessary for normal growth and development, though too much can cause birth defects. It is used to treat skin conditions such as psoriasis and acne vulgaris, as well as acute promyelocytic leukemia.

Panretin

is the brand name

image of different drug pills on a surface

Tretinoin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Panretin

Alitretinoin

2006

3

Effectiveness

How Tretinoin Affects Patients

Alitretinoin is a naturally occurring form of vitamin A that is used to treat skin lesions in people with AIDS-related Kaposi's sarcoma. In laboratory studies, alitretinoin has been shown to slow the growth and spread of Kaposi's sarcoma cells.

How Tretinoin works in the body

Alitretinoin binds to and activates all known receptors within cells. This triggers a process that helps control how cells divide and change. This process helps both normal and cancerous cells.

When to interrupt dosage

The measure of Tretinoin is contingent upon the determined condition, including Eczema, Kaposi's Sarcoma AIDS Related and cutaneous lesions. The dosage fluctuates in accordance with the technique of delivery (e.g. Capsule or Gel - Topical) featured in the table below.

Condition

Dosage

Administration

refractory Eczema of the hand

, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg

, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream

Acquired Immunodeficiency Syndrome

, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg

, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream

cutaneous lesions

, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg

, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream

Eczema

, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg

, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream

Eczema

, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg

, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream

Warnings

Tretinoin Contraindications

Condition

Risk Level

Notes

Kidney Failure

Do Not Combine

Hypervitaminosis A

Do Not Combine

Pulse Frequency

Do Not Combine

Hypertriglyceridemia

Do Not Combine

Hypercholesterolemia

Do Not Combine

Hypothyroidism

Do Not Combine

Pulse Frequency

Do Not Combine

Fructose Intolerance

Do Not Combine

Liver Failure

Do Not Combine

There are 20 known major drug interactions with Tretinoin.

Common Tretinoin Drug Interactions

Drug Name

Risk Level

Description

Clomocycline

Major

The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Clomocycline.

Demeclocycline

Major

The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Demeclocycline.

Doxycycline

Major

The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Doxycycline.

Eravacycline

Major

The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Eravacycline.

Metacycline

Major

The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Metacycline.

image of a doctor in a lab doing drug, clinical research

Tretinoin Novel Uses: Which Conditions Have a Clinical Trial Featuring Tretinoin?

Currently, 6 active studies are investigating the potential of Tretinoin to ameliorate Eczema, refractory Hand Eczema and Cutaneous Lesions.

Condition

Clinical Trials

Trial Phases

Eczema

0 Actively Recruiting

Acquired Immunodeficiency Syndrome

0 Actively Recruiting

refractory Eczema of the hand

0 Actively Recruiting

Eczema

0 Actively Recruiting

cutaneous lesions

0 Actively Recruiting

Tretinoin Reviews: What are patients saying about Tretinoin?

5

Patient Review

12/16/2017

Tretinoin for Acne

Like most things in life, you have to tough it out a bit before seeing results. My skin was pretty red and sensitive when I first started using this product, but after just one month I'm really happy with the results. If you're dealing with hormonal breakouts, hang in there--this treatment really helped me!

5

Patient Review

9/11/2021

Tretinoin for Acne

This is my favorite treatment. I really appreciate how well it works.

4.3

Patient Review

2/8/2022

Tretinoin for Acne

My son's acne was greatly reduced after just three weeks of using this product. He only used it once a week, as per the doctor's instruction. I'm hoping that with continued use, all of his acne will eventually disappear.

3.7

Patient Review

7/29/2018

Tretinoin for Acne

I've only been using this for a week, but I can tell it's making my acne better. My face is clearing up and getting smoother, although it's also become more sensitive. I'm hoping these side effects will go away soon.

1

Patient Review

5/14/2018

Tretinoin for Acne

DO NOT USE THIS CREAM! I used it as directed and my skin started BURNING when I would wash it. My face swelled up, turned red, and felt dry and scaly. It was so painful that I had to ice my face and use aloe for two days.

1

Patient Review

6/2/2020

Tretinoin for Acne

I used this product for two years as directed, and I slowly started experiencing headaches, tinnitus, dizziness, and Double vision. This caused a lot of pressure in my head. Please consult with a doctor before using this product.

1

Patient Review

3/6/2021

Tretinoin for Acne

I've been using this treatment for six months with no improvement. I have cystic acne and scars, but I think it might be a hormonal imbalance that's causing new pimples to grow. This is my fourth session of treatment, but I'm starting to doubt its efficacy.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tretinoin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the dangers of tretinoin?

"The medication may cause a brief sensation of warmth or stinging when it is first applied. The medication may also cause the skin to become red, dry, itchy, or to scale during the first 2-4 weeks of use. These effects usually decrease over time."

Answered by AI

What's the difference between retinol and tretinoin?

"Retinol and tretinoin are both treatments derived from vitamin A, typically used in topical creams form to address various skin conditions. Tretinoin is more potent than retinol."

Answered by AI

Can tretinoin remove dark spots?

"The active ingredient tretinoin can help improve the appearance of dark spots and uneven skin tone by reducing the amount of melanin pigment in the skin. In general, tretinoin for this purpose is combined with other skin lightening treatments, such as chemical peels."

Answered by AI

How long does it take tretinoin to work?

"If you start to see tretinoin working within 2-3 weeks, but it full benefits take 6 weeks or more, speak to your doctor. If you don't see any improvement after 12 weeks, or if you see significant improvement and think you should start using it less frequently."

Answered by AI