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What is Tretinoin
AlitretinoinThe Generic name of this drug
Treatment SummaryTretinoin, also known as retinoic acid, is a drug used to regulate gene expression in development and growth, as well as in cancer. It is derived from vitamin A and is necessary for normal growth and development, though too much can cause birth defects. It is used to treat skin conditions such as psoriasis and acne vulgaris, as well as acute promyelocytic leukemia.
Panretinis the brand name
Tretinoin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Panretin
Alitretinoin
2006
3
Effectiveness
How Tretinoin Affects PatientsAlitretinoin is a naturally occurring form of vitamin A that is used to treat skin lesions in people with AIDS-related Kaposi's sarcoma. In laboratory studies, alitretinoin has been shown to slow the growth and spread of Kaposi's sarcoma cells.
How Tretinoin works in the bodyAlitretinoin binds to and activates all known receptors within cells. This triggers a process that helps control how cells divide and change. This process helps both normal and cancerous cells.
When to interrupt dosage
The measure of Tretinoin is contingent upon the determined condition, including Eczema, Kaposi's Sarcoma AIDS Related and cutaneous lesions. The dosage fluctuates in accordance with the technique of delivery (e.g. Capsule or Gel - Topical) featured in the table below.Condition
Dosage
Administration
cutaneous lesions
, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream
Eczema
, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream
Eczema
, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream
Kaposi's Sarcoma AIDS Related
, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream
refractory Eczema of the hand
, 10.0 mg, 30.0 mg, 0.1 %, 0.006 mg/mg, 0.001 mg/mg, 0.0005 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Cream - Topical, Cream
Warnings
Tretinoin ContraindicationsCondition
Risk Level
Notes
Kidney Failure
Do Not Combine
Hypervitaminosis A
Do Not Combine
Pulse Frequency
Do Not Combine
Hypertriglyceridemia
Do Not Combine
Hypercholesterolemia
Do Not Combine
Hypothyroidism
Do Not Combine
Pulse Frequency
Do Not Combine
Hereditary fructose intolerance
Do Not Combine
Liver Failure
Do Not Combine
Common Tretinoin Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Metacycline.
Tretinoin Novel Uses: Which Conditions Have a Clinical Trial Featuring Tretinoin?
Currently, 6 active studies are investigating the potential of Tretinoin to ameliorate Eczema, refractory Hand Eczema and Cutaneous Lesions.Condition
Clinical Trials
Trial Phases
Eczema
0 Actively Recruiting
cutaneous lesions
3 Actively Recruiting
Not Applicable
Eczema
0 Actively Recruiting
Kaposi's Sarcoma AIDS Related
0 Actively Recruiting
refractory Eczema of the hand
0 Actively Recruiting
Tretinoin Reviews: What are patients saying about Tretinoin?
5Patient Review
12/16/2017 Like most things in life, you have to tough it out a bit before seeing results. My skin was pretty red and sensitive when I first started using this product, but after just one month I'm really happy with the results. If you're dealing with hormonal breakouts, hang in there--this treatment really helped me!
5Patient Review
9/11/2021 This is my favorite treatment. I really appreciate how well it works.
4.3Patient Review
2/8/2022 My son's acne was greatly reduced after just three weeks of using this product. He only used it once a week, as per the doctor's instruction. I'm hoping that with continued use, all of his acne will eventually disappear.
3.7Patient Review
7/29/2018 I've only been using this for a week, but I can tell it's making my acne better. My face is clearing up and getting smoother, although it's also become more sensitive. I'm hoping these side effects will go away soon.
1Patient Review
5/14/2018 DO NOT USE THIS CREAM! I used it as directed and my skin started BURNING when I would wash it. My face swelled up, turned red, and felt dry and scaly. It was so painful that I had to ice my face and use aloe for two days.
1Patient Review
6/2/2020 I used this product for two years as directed, and I slowly started experiencing headaches, tinnitus, dizziness, and Double vision. This caused a lot of pressure in my head. Please consult with a doctor before using this product.
1Patient Review
3/6/2021 I've been using this treatment for six months with no improvement. I have cystic acne and scars, but I think it might be a hormonal imbalance that's causing new pimples to grow. This is my fourth session of treatment, but I'm starting to doubt its efficacy.
Patient Q&A Section about tretinoin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the dangers of tretinoin?
"The medication may cause a brief sensation of warmth or stinging when it is first applied. The medication may also cause the skin to become red, dry, itchy, or to scale during the first 2-4 weeks of use. These effects usually decrease over time."
Answered by AI
What's the difference between retinol and tretinoin?
"Retinol and tretinoin are both treatments derived from vitamin A, typically used in topical creams form to address various skin conditions. Tretinoin is more potent than retinol."
Answered by AI
Can tretinoin remove dark spots?
"The active ingredient tretinoin can help improve the appearance of dark spots and uneven skin tone by reducing the amount of melanin pigment in the skin. In general, tretinoin for this purpose is combined with other skin lightening treatments, such as chemical peels."
Answered by AI
How long does it take tretinoin to work?
"If you start to see tretinoin working within 2-3 weeks, but it full benefits take 6 weeks or more, speak to your doctor. If you don't see any improvement after 12 weeks, or if you see significant improvement and think you should start using it less frequently."
Answered by AI