Trelstar

Therapeutic procedure, Prostatic Neoplasms

Treatment

3 FDA approvals

0 Active Studies for Trelstar

Treatment for

Therapeutic procedure

What is Trelstar

Triptorelin

The Generic name of this drug

Treatment Summary

Triptorelin is a hormone medication used to reduce the production of testosterone. It is a more potent form of luteinizing hormone-releasing hormone (LHRH). When taken over a long period of time, it will decrease the levels of hormones like LH and FSH, and lower testosterone concentrations to the levels found in men who have been surgically castrated.

Trelstar

is the brand name

image of different drug pills on a surface

Trelstar Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Trelstar

Triptorelin

2000

Approved as Treatment by the FDA

Triptorelin, also known as Trelstar, is approved by the FDA for 3 uses which include Advanced Prostate Cancer and Prostatic Neoplasms .

Advanced Prostate Cancer

Prostatic Neoplasms

Therapeutic procedure

Used in combination with Triptorelin for Controlled ovarian hyperstimulation therapy

Effectiveness

How Trelstar Affects Patients

After taking triptorelin, there is a temporary increase in hormones like FSH, LH, estradiol, and testosterone. The effects of this surge can worsen prostate cancer symptoms like trouble urinating, bone pain, and blood in the urine. Within 2-4 weeks, the hormones decrease and testosterone levels drop to those of men who have been surgically castrated. This can affect tissues and functions that rely on these hormones. The effects of triptorelin can usually be reversed when the drug is stopped.

How Trelstar works in the body

Triptorelin is a man-made drug that is similar to a hormone found naturally in the body called gonadotropin releasing hormone (GnRH). Studies on animals show that it is much more effective than the natural hormone at stimulating the production of luteinizing hormone and follicle-stimulating hormone.

When to interrupt dosage

The suggested dosage of Trelstar is contingent upon the determined condition. The amount of dosage is also subject to the procedure of delivery (e.g. Injection, powder, lyophilized, for suspension; Kit or Injection, powder, for suspension, extended release) as detailed in the table below.

Condition

Dosage

Administration

Prostatic Neoplasms

, 3.75 mg/mL, 11.25 mg/mL, 22.5 mg/mL, 11.25 mg, 22.5 mg, 3.75 mg, 0.1 mg/mL

, Kit, Intramuscular, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Subcutaneous, Solution, Solution - Subcutaneous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular

Therapeutic procedure

, 3.75 mg/mL, 11.25 mg/mL, 22.5 mg/mL, 11.25 mg, 22.5 mg, 3.75 mg, 0.1 mg/mL

Warnings

There are 20 known major drug interactions with Trelstar.

Common Trelstar Drug Interactions

Drug Name

Risk Level

Description

Capromab pendetide

Major

Triptorelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.

Corifollitropin alfa

Major

The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Triptorelin.

Hydroxyzine

Major

The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Hydroxyzine.

Mobocertinib

Major

The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Mobocertinib.

Ziprasidone

Major

The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Ziprasidone.

Trelstar Toxicity & Overdose Risk

Taking triptorelin may lead to hot flushes, body or joint pain, impotence, headaches, injection site pain, fatigue, high blood pressure, dizziness, diarrhea, vomiting, trouble sleeping, emotional instability, anemia, itching, urinary tract infections, and difficulty urinating. Pregnant women should not take triptorelin as it can cause complications with pregnancy and harm to the fetus. Studies done on pregnant rats showed dangerous effects on the mother and unborn baby.

image of a doctor in a lab doing drug, clinical research

Trelstar Novel Uses: Which Conditions Have a Clinical Trial Featuring Trelstar?

Three active clinical trials are currently underway to examine the efficacy of Trelstar in treating Advanced Prostate Cancer.

Condition

Clinical Trials

Trial Phases

Therapeutic procedure

0 Actively Recruiting

Prostatic Neoplasms

0 Actively Recruiting

Trelstar Reviews: What are patients saying about Trelstar?

Patient Review

10/8/2020

Trelstar for Advanced Form of Prostate Cancer

I completed 45 days of radiation therapy, and I'm now on my third year of hormone therapy. The side effects have been manageable, but the impotence is a big issue for me.

2.7

Patient Review

7/20/2011

Trelstar for Advanced Form of Prostate Cancer

I was using this treatment alongside radiation to treat my cancer. I had surgery and everything went well, but the Androgen deprivation has been really tough. I've had all sorts of problems like depression, weight gain, muscle cramps, and more. My urologist convinced me to stick it out for a few more months though.

Patient Q&A Section about trelstar

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does trelstar treat?

"Trelstar is a hormone that regulates many processes in the body. Trelstar injections are used in men to treat the symptoms of prostate cancer, but it does not treat the cancer itself."

Answered by AI

How is trelstar given?

"This medication should be injected into the muscle of your buttocks by a health care professional, usually once every 3 months (12 weeks) or as directed by your doctor."

Answered by AI

Is trelstar the same as Lupron?

"Trelstar and Lupron Depot are both drugs that contain drugs that belong to a class of medications called gonadotropin-releasing hormone (GnRH) agonists. Trelstar contains triptorelin, while Lupron Depot contains leuprolide."

Answered by AI

How do you give a trelstar injection?

"You should only take TRELSTAR under the supervision of a physician. TRELSTAR is injected into a muscle in the buttock, either left or right. The amount you are given and how often you receive the injection depend on the strength of the TRELSTAR you are taking (see Table 1). The powder form of TRELSTAR is reconstituted with sterile water before injection."

Answered by AI