Transderm Scop

Nausea, Anesthetic premedication therapy, Airsickness + 2 more

Treatment

5 Active Studies for Transderm Scop

Treatment for

Nausea

What is Transderm Scop

Scopolamine

The Generic name of this drug

Treatment Summary

Scopolamine is a medication used to block the activity of acetylcholine, a neurotransmitter in the body. It is derived from plants in the Solanaceae family and was first synthesized in 1959. Scopolamine is most commonly used to prevent nausea and vomiting caused by motion sickness or surgery. It was first approved by the FDA in 1979 and is available as both tablets and a patch.

Belladonna Alkaloids with Phenobarbital

is the brand name

image of different drug pills on a surface

Transderm Scop Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Belladonna Alkaloids with Phenobarbital

Scopolamine

1966

Effectiveness

How Transderm Scop Affects Patients

Scopolamine is a medication that works by blocking the nerve pathways that control the body's sweat and saliva production. It is usually applied as a patch that works over three days and can still be detected in urine up to 108 hours later. Using scopolamine may increase eye pressure, so it should be used with caution in those with glaucoma. It can also cause mental side effects, like confusion, seizures, and changes in behavior. Women with preeclampsia should avoid using this drug. People with stomach or urinary problems should be monitored and scopolamine should be stopped if these problems get worse. Blurred vision can

How Transderm Scop works in the body

Acetylcholine is a neurotransmitter that helps regulate the body through five different types of receptors. Scopolamine is an anticholinergic drug which blocks these receptors, leading to therapeutic and adverse effects. It is used to treat nausea and vomiting by altering signaling in the central nervous system. Scopolamine may also be useful in treating mental health disorders like schizophrenia and substance abuse.

When to interrupt dosage

The amount of Transderm Scop is contingent upon the diagnosed ailment, including Preanesthetic Medication, Nausea and Motion Sickness. The measure of dosage is dependent on the delivery approach (e.g. Oral or Elixir) specified in the table below.

Condition

Dosage

Administration

Motion Sickness

, 0.1 mg/hour, 0.0065 mg/mL, 0.0065 mg, 0.4 mg/mL, 0.0195 mg, 0.025 mg/mg, 0.05 mg/mg, 0.4 mg, 0.0033 mg, 1.0 mg, 3.0 mg/mL, 2.5 mg/mL, 0.006 mg/mL, 1.5 mg, 0.6 mg/mL, 0.00065 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Oral, Elixir, Elixir - Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Liquid - Oral, Solution - Ophthalmic, Ophthalmic, Tablet, soluble, Tablet, soluble - Oral, Topical, Patch, extended release - Topical, Patch, Patch - Transdermal

Anesthetic premedication therapy

, 0.1 mg/hour, 0.0065 mg/mL, 0.0065 mg, 0.4 mg/mL, 0.0195 mg, 0.025 mg/mg, 0.05 mg/mg, 0.4 mg, 0.0033 mg, 1.0 mg, 3.0 mg/mL, 2.5 mg/mL, 0.006 mg/mL, 1.5 mg, 0.6 mg/mL, 0.00065 mg/mL

Airsickness

, 0.1 mg/hour, 0.0065 mg/mL, 0.0065 mg, 0.4 mg/mL, 0.0195 mg, 0.025 mg/mg, 0.05 mg/mg, 0.4 mg, 0.0033 mg, 1.0 mg, 3.0 mg/mL, 2.5 mg/mL, 0.006 mg/mL, 1.5 mg, 0.6 mg/mL, 0.00065 mg/mL

Nausea

, 0.1 mg/hour, 0.0065 mg/mL, 0.0065 mg, 0.4 mg/mL, 0.0195 mg, 0.025 mg/mg, 0.05 mg/mg, 0.4 mg, 0.0033 mg, 1.0 mg, 3.0 mg/mL, 2.5 mg/mL, 0.006 mg/mL, 1.5 mg, 0.6 mg/mL, 0.00065 mg/mL

Nausea

, 0.1 mg/hour, 0.0065 mg/mL, 0.0065 mg, 0.4 mg/mL, 0.0195 mg, 0.025 mg/mg, 0.05 mg/mg, 0.4 mg, 0.0033 mg, 1.0 mg, 3.0 mg/mL, 2.5 mg/mL, 0.006 mg/mL, 1.5 mg, 0.6 mg/mL, 0.00065 mg/mL

Warnings

Transderm Scop Contraindications

Condition

Risk Level

Notes

Uropathy Obstructive

Do Not Combine

Arterial Occlusive Diseases

Do Not Combine

Myasthenia Gravis

Do Not Combine

Ulcerative Colitis

Do Not Combine

Cardiovascular Physiological Phenomena

Do Not Combine

Ulcerative Colitis

Do Not Combine

Uterine Inertia

Do Not Combine

Pulse Frequency

Do Not Combine

Intestinal Pseudo-Obstruction

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Scopolamine may interact with Pulse Frequency

There are 20 known major drug interactions with Transderm Scop.

Common Transderm Scop Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Scopolamine is combined with Aclidinium.

Azelastine

Major

Scopolamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Scopolamine is combined with Cimetropium.

Deutetrabenazine

Major

The risk or severity of sedation and somnolence can be increased when Scopolamine is combined with Deutetrabenazine.

Eluxadoline

Major

The risk or severity of constipation can be increased when Scopolamine is combined with Eluxadoline.

Transderm Scop Toxicity & Overdose Risk

Overdosing on scopolamine can lead to symptoms such as drowsiness, confusion, agitation, hallucinations, seizures, dry skin and mouth, increased heart rate, high blood pressure, and abnormal heart rhythms. If a person has swallowed a patch, it may need to be removed or activated charcoal administered. In animals, the toxic dose has been found to be 1880 mg/kg in mice and 1270 mg/kg in rats when taken by mouth, and 1650 mg/kg in mice and 296 mg/kg in rats when taken through the skin.

image of a doctor in a lab doing drug, clinical research

Transderm Scop Novel Uses: Which Conditions Have a Clinical Trial Featuring Transderm Scop?

A total of 4 active studies are currently investigating the potential of Transderm Scop in providing relief from Motion Sickness, Nausea and Airsickness.

Condition

Clinical Trials

Trial Phases

Motion Sickness

0 Actively Recruiting

Nausea

5 Actively Recruiting

Phase 2, Phase 3, Phase 1, Not Applicable

Airsickness

2 Actively Recruiting

Not Applicable, Phase 3

Nausea

0 Actively Recruiting

Anesthetic premedication therapy

0 Actively Recruiting

Transderm Scop Reviews: What are patients saying about Transderm Scop?

Patient Review

4/15/2021

Transderm Scop for Motion Sickness

Works wonderfully, but I did experience one side effect of huge dilated pupils.

Patient Review

2/16/2018

Transderm Scop for Motion Sickness

These patches are amazing for people who suffer from motion sickness. They've helped me so much, especially when it comes to diving and boating.

Patient Review

6/9/2022

Transderm Scop for Prevention of Motion Sickness

The patch really saved me on my recent fishing trip. I get motion sickness very easily, but this allowed me to participate in the family fun without feeling nauseous. I even used it for a few days in a row - no issues! The only downside was that I lost my appetite a bit, but it was well worth it given how well the patch worked.

Patient Review

3/3/2017

Transderm Scop for Prevention of Motion Sickness

This is the only thing that has helped me with motion sickness for cruises. A little bit itchy after I removed the patch. Blurred vision for a day after wearing it almost 4 days.

Patient Review

2/5/2017

Transderm Scop for Motion Sickness

I found this to be really effective in stopping my hot flashes, even after wearing it for 36 hours straight. It's also been great on cruises and other vacations. The only time it didn't work well for me was when I went snorkeling.

4.7

Patient Review

10/20/2015

Transderm Scop for Motion Sickness

I have dry mouth and dizziness, but this treatment doesn't make me feel nauseous or sick to my stomach.

4.3

Patient Review

8/6/2015

Transderm Scop for Motion Sickness

It worked great at first, but then I started getting an itchy rash where I placed the patch. So unfortunately, I won't be able to use this again.

3.3

Patient Review

5/19/2019

Transderm Scop for Motion Sickness

I found this patch to be helpful while using it; however, removing it caused some nasty after-effects like vertigo and blurred vision. Additionally, I lost my appetite for a few days. Overall, not sure if the short-term benefits are worth the long-term negatives.

Patient Review

2/19/2020

Transderm Scop for Motion Sickness

The benefits of this drug do not outweigh the withdrawal effects. Just two days after removing the patch, I experienced nausea and disorientation. My pupils also became enlarged.

2.7

Patient Review

8/20/2015

Transderm Scop for Motion Sickness

Blurry vision, sore throat, and other nasty withdrawal symptoms make it hard to recommend this treatment.

2.3

Patient Review

11/4/2019

Transderm Scop for Prevention of Motion Sickness

I followed my doctor's orders by applying the patch the night before travel. However, I woke up disoriented and feeling very nauseous. I had to take the patch off immediately and have been dealing with headache 16 hours later. Overall, not a great experience.

Patient Review

6/15/2016

Transderm Scop for Prevent Nausea and Vomiting After Surgery

This medication caused more problems than it solved. I developed mental health issues and my mouth became incredibly dry and sore.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about transderm scop

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Transderm Scop over the counter?

"The drug Scopolamine (Transderm Scop) is not able to be bought over the counter and requires a prescription from a medical provider. This is because it can have severe side effects if the person taking it has other medical conditions or is taking other medications."

Answered by AI

When do you apply Transderm Scop?

"If you are prone to motion sickness, it is recommended that you apply a Transderm Scop patch to a hairless area behind your ear at least four hours before the activity. If you need the treatment for more than three days, remove the patch from behind your ear."

Answered by AI

Is Transderm Scop still available?

"Perrigo has discontinued scopolamine transdermal system due to business reasons. The discontinuation is not due to product quality, safety, or efficacy concerns. Scopolamine transdermal system has been listed on the FDA Drug Shortage site. After researching the issue further, Perrigo has confirmed that the product has been discontinued."

Answered by AI

What is Transderm Scop used for?

"Scopolamine is used to stop nausea and vomiting that is caused by motion sickness or medicine used during surgery. Scopolamine is a type of medicine called an antimuscarinic. Scopolamine works by blocking the effects of a natural substance called acetylcholine on the central nervous system."

Answered by AI