Tobradex

Bacteria, Cystic Fibrosis, Septicemia + 19 more

Treatment

1 Active Study for Tobradex

What is Tobradex

Tobramycin

The Generic name of this drug

Treatment Summary

Tobramycin is an antibiotic medication used to treat a range of bacterial infections. It was developed in 1975 and can be administered by inhalation, injection, or applied directly to the eye. Tobramycin is especially effective against Pseudomonas aeruginosa, which is resistant to many other antibiotics. However, it can cause side effects such as kidney and hearing damage, so it is used cautiously.

Tobrex

is the brand name

image of different drug pills on a surface

Tobradex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tobrex

Tobramycin

1981

166

Effectiveness

How Tobradex Affects Patients

Tobramycin is an antibiotic used to treat different types of bacterial infections, such as those caused by _Enterobacteriaceae_, _Escherichia coli_, _Klebsiella pneumoniae_, and _Pseudomonas aeruginosa_. It also works on some Gram-positive bacteria, including methicillin-resistant (MRSA) and vancomycin-resistant strains. Taking too much tobramycin can cause kidney or ear damage, muscle weakness, or hearing loss in unborn babies. It can also cause allergic reactions, including severe skin reactions.

How Tobradex works in the body

Tobramycin works by damaging bacteria's cell membranes and preventing them from making proteins. It does this by binding to the cell's ribosome, which is responsible for making proteins. This binding blocks the ribosome from making new proteins and also disrupts the cell membrane, which allows more of the tobramycin into the cell. Bacteria can build up a resistance to tobramycin by modifying the ribosome or the tobramycin itself, which makes the drug less effective. Tobramycin is only effective against certain types of bacteria, such as Gram-negative and some Gram-positive bacteria.

When to interrupt dosage

The advised dosage of Tobradex is reliant upon the diagnosed state, including Cystic Fibrosis (CF), steroid-responsive inflammation and Meningitis, Bacterial. The amount of dosage can be found in the table below, contingent upon the method of delivery.

Condition

Dosage

Administration

concomitant use of NSAID

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Inflammation

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Cystic Fibrosis

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Bacterial Infections

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Burkholderia Cepacia Infection

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Bacterial Peritonitis

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

FEV1 <25% predicted

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Septicemia

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Conjunctivitis

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Urinary tract infection

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Eye Infections, Bacterial

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Otitis

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

External auditory canal structure

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

FEV1 >80% predicted

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Eye Infections

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Cystic Fibrosis

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Bacteria

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

ocular bacterial infections

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Adrenal Cortex Hormones

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Intraabdominal Infections

, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg

, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)

Warnings

Tobradex Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Tobradex.

Common Tobradex Drug Interactions

Drug Name

Risk Level

Description

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Tobramycin is combined with Neomycin.

Tenofovir

Major

Tobramycin may increase the nephrotoxic activities of Tenofovir.

Tenofovir alafenamide

Major

Tobramycin may increase the nephrotoxic activities of Tenofovir alafenamide.

Tenofovir disoproxil

Major

Tobramycin may increase the nephrotoxic activities of Tenofovir disoproxil.

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Tobramycin.

Tobradex Toxicity & Overdose Risk

Tobramycin can cause serious side effects if taken in large doses, such as damage to the kidneys or ears, nerve or muscle problems, or difficulty breathing. Treatment for an overdose of tobramycin focuses on managing the symptoms and hemodialysis may be used to clear excess of the drug from the body. Taking tobramycin by accident is unlikely to cause an overdose, as it is not well absorbed in the digestive system. Animal studies have found that the toxic dose for mice and rats to be between 367-1030 mg/kg when administered through injection and more than 7500 mg/kg when taken orally.

image of a doctor in a lab doing drug, clinical research

Tobradex Novel Uses: Which Conditions Have a Clinical Trial Featuring Tobradex?

At present, 8 active trials are investigating the potential of Tobradex to alleviate Cystic Fibrosis, Bacterial Ocular Infections and Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Bacterial Infections

0 Actively Recruiting

Meningitis, Bacterial

0 Actively Recruiting

Bacteria

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Eye Infections

0 Actively Recruiting

concomitant use of NSAID

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Osteomyelitis

0 Actively Recruiting

Burkholderia Cepacia Infection

0 Actively Recruiting

Adrenal Cortex Hormones

0 Actively Recruiting

Bacterial Peritonitis

0 Actively Recruiting

FEV1 <25% predicted

0 Actively Recruiting

ocular bacterial infections

0 Actively Recruiting

Urinary tract infection

0 Actively Recruiting

Eye Infections, Bacterial

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Intraabdominal Infections

1 Actively Recruiting

Not Applicable

Septicemia

0 Actively Recruiting

External auditory canal structure

0 Actively Recruiting

Otitis

0 Actively Recruiting

Tobradex Reviews: What are patients saying about Tobradex?

5

Patient Review

1/9/2010

Tobradex for Bacterial Infection of the Eyelid

I was amazed at how quickly this treatment worked. I had been dealing with a lot of pain for months, and after starting this medication, it went away almost immediately.

5

Patient Review

1/15/2014

Tobradex for Infection Confined to the Surface of the Eye

My optometrist suggest this for my corneal infection and it worked like a charm!

5

Patient Review

8/3/2010

Tobradex for Pink Eye from Bacterial Infection

I slept in my contacts and bacteria got into my eyes, which made it difficult for me to be exposed to any light whatsoever.

5

Patient Review

4/7/2013

Tobradex for Scratch Wound on Cornea

Trobadex ointment is a complete life saver. I had an old tube from when I used it for pink eye and applied it to my dog scratch wound before bed. The pain was completely gone by the next morning!

4.7

Patient Review

6/24/2011

Tobradex for Inflammation of Eyelid Edges and the Lining of the Eye

Although it caused my vision to blur, this drug was very effective in reducing inflammation and irritation.

3.7

Patient Review

2/9/2010

Tobradex for Inflammation of Eyelid Edges and the Lining of the Eye

It took a little bit of research to understand how to properly use this cream, but it was well worth it. The pain and swelling in my eyelid went away within just three days.

3.3

Patient Review

1/16/2020

Tobradex for Infection Confined to the Surface of the Eye

I was prescribed this for an infection, but unfortunately it gave me terrible diarrhea. It did help with the itchiness though.

1.7

Patient Review

7/7/2011

Tobradex for Bacterial Infection of the Eyelid

My son has been taking this perscription since July 4, 2011. He is blind and started with 1 drop in right eye every 3 hours for 2 weeks, then moved up to 1 drip 4 times daily for 2 weeks.

1.3

Patient Review

4/6/2015

Tobradex for Inflammation of the Eye

I took this for A.S related iritis, but unfortunately I'm allergic to one of the main ingredients (white petrolium jelly) and it just gave me a red puffy painful rash.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tobradex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long can you use Tobradex eye drops?

"If you are an adult, put one drop of this medication into your conjunctival sac(s) every 4 to 6 hours while you are awake. For the first 24 to 48 hours, you may need to put a drop in every 2 hours while you are awake. Use this medication for 14 days, but do not use it for more than 24 days."

Answered by AI

How many times a day can I use Tobradex?

"Adults should use a 1/2-inch strip of ointment in the eye up to three or four times a day, and children's use and dose must be determined by a doctor."

Answered by AI

What is Tobradex used for?

"Tobradex Eye Drops are used to treat inflammation, corneal injury and bacterial infections in the external part of the eye. Your doctor will have examined your eye(s) and decided that Tobradex Eye Drops are the right medicine for you."

Answered by AI

Is Tobradex a steroid?

"The eye medication Tobradex, which is a combination of the steroid tobramycin and the antibiotic dexamethasone, is effective in treating eye inflammation and bacterial infections. However, if it is used for a long time, it can cause high eye pressure and eye injury."

Answered by AI

Clinical Trials for Tobradex

Image of UPMC-Presbyterian Hospital in Pittsburgh, United States.

Blue Light for Infections

18 - 65
All Sexes
Pittsburgh, PA

Our data suggest that modulating the characteristics of light carries the potential to modify the host response to injury and critical illness and thus, improve outcome. The ability to modify the host response to the stress of major operations and sepsis carries immense potential to improve patient care. The primary purpose of this study is to determine if exposure to bright blue (442nm) enriched light, by comparison to ambient white fluorescent light, reduces the inflammatory response or organ dysfunction in patients undergoing 1) medical treatment for pneumonia, 2) a 2-stage arthroplasty for surgical management of a septic joint, 3) surgery for a necrotizing soft tissue infection (NSTI), and 4) surgery for an intraabdominal infection (e.g., diverticulitis). We will expose participants to one of two (2) lighting conditions: 1) high illuminance (\~1700 lux,), blue (442nm) spectrum enriched light and 2) ambient white fluorescent light that provides the standard environmental lighting (\~300-400 lux, no predominant spectrum) of the hospital. Both cohorts will be exposed to a 12 hours:12 hours light:dark cycle photoperiod. Those subjects assigned to blue light will be asked to shine this small portable blue enriched light on themselves from 0800 to 2000 for 3 days. At the transition from light to dark, the blue-enriched light is turned off, and additional blue wavelength light removed with an amber filter. Thus, the total period of intervention is 72 hours. The outcome of interest is change in the inflammatory response after surgery for appendicitis or diverticulitis as measured by the following parameters: white blood cell count, heart rate, the development of abdominal abscess, serum cytokine concentrations. The outcome of interest is change in the inflammatory response during pneumonia as measured by the following parameters: white blood cell count, heart rate, and serum cytokine concentrations.

Recruiting
Has No Placebo

UPMC-Presbyterian Hospital (+2 Sites)

Matthew R Rosengart, MD MPH