Timoptic

Migraine, Open-angle glaucoma, Migraine Disorders + 6 more
Treatment
20 Active Studies for Timoptic

What is Timoptic

TimololThe Generic name of this drug
Treatment SummaryTimolol is a medication used to lower pressure in the eyes and treat high blood pressure. It is available in eye drop solution or tablet form, and was approved by the FDA in 1978. There are various manufacturers of this drug, making it a popular choice for treating conditions such as glaucoma and hypertension.
Timopticis the brand name
Timoptic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Timoptic
Timolol
1978
167

Effectiveness

How Timoptic Affects PatientsTimolol is a drug that can be used to quickly lower pressure inside the eyes, as well as reduce blood pressure, heart rate, and sympathetic activity. It starts working about 20 minutes after an ophthalmic dose and can last up to 24 hours if given in a 0.5% or 0.25% dose.
How Timoptic works in the bodyTimolol blocks certain receptors in the heart, blood vessels and bronchial muscles, which helps lower blood pressure. It also reduces the production of aqueous humor in the eye, likely by decreasing the blood supply to the ciliary body or interfering with prostaglandin synthesis.

When to interrupt dosage

The suggested measure of Timoptic is determined by the diagnosed condition, such as Open Angle Glaucoma, requiring additional or substitution treatment and Ocular Hypertension. The amount of dosage differs based on the method of administration (e.g. Ophthalmic or Solution, gel forming / drops) as shown in the table below.
Condition
Dosage
Administration
Migraine Disorders
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open-angle glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Migraine
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
inadequate response to other therapeutic measures
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
insufficient response to beta-blockers
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
requiring adjunctive or replacement therapy
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open Angle Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Ocular Hypertension
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic

Warnings

Timoptic has seven contraindications and should not be administered when experiencing any of the situations outlined in the following table.Timoptic Contraindications
Condition
Risk Level
Notes
Lung Diseases, Obstructive
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Atrioventricular Block
Do Not Combine
Asthma
Do Not Combine
Heart Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Timolol may interact with Pulse Frequency
There are 20 known major drug interactions with Timoptic.
Common Timoptic Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Timolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Timolol.
Abediterol
Major
Timolol may decrease the bronchodilatory activities of Abediterol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Timolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Timolol.
Timoptic Toxicity & Overdose RiskThe toxic dose of timolol maleate in rats is 1028mg/kg and 1137mg/kg in mice. An overdose may cause dizziness, headaches, difficulty breathing, a slow heart rate, or even cardiac arrest. Dialysis can be used to reverse the effects of timolol overdose, although those with poor kidney function might not find it as effective.
image of a doctor in a lab doing drug, clinical research

Timoptic Novel Uses: Which Conditions Have a Clinical Trial Featuring Timoptic?

172 active trials are assessing the benefits of Timoptic in managing insufficient response to beta-blockers, insufficient response to other therapies and requiring adjunctive or replacement therapy.
Condition
Clinical Trials
Trial Phases
Open-angle glaucoma
45 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1
Open Angle Glaucoma
10 Actively Recruiting
Phase 3, Not Applicable, Phase 4
Ocular Hypertension
10 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
requiring adjunctive or replacement therapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Migraine
51 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1
Glaucoma
0 Actively Recruiting
insufficient response to beta-blockers
0 Actively Recruiting

Timoptic Reviews: What are patients saying about Timoptic?

5Patient Review
7/20/2009
Timoptic for Closed Angle Glaucoma
I've been on this medication for several years and it's lowered my intraocular pressure from 28 to 16. No complaints here, just great results.
5Patient Review
2/3/2017
Timoptic for Wide-Angle Glaucoma
I've been using this medication for three years now, and it has really helped to improve my overall eye health. It's lowered my intraocular pressure (IOP) and prevented me from losing any more of my vision.
5Patient Review
1/3/2012
Timoptic for Increased Pressure in the Eye
I've been using this medication for nine months now, and my eye pressure has lowered from 28 to 18.
4Patient Review
4/18/2009
Timoptic for Closed Angle Glaucoma
So far, so good. I worry that my eyes will get used to it, and it wont work as well as it should.
3.7Patient Review
10/24/2009
Timoptic for High Eye Pressure or Glaucoma that May Worsen without Treatment
After taking this medication, I feel exhausted and like I need to take a nap.
3Patient Review
12/28/2015
Timoptic for High Eye Pressure or Glaucoma that May Worsen without Treatment
My doctor was pleased to see my blood pressure drop from 28 to 21 within two months. However, I started experiencing daily lethargy and extreme foot pain, cold feet and hands. When I reported these symptoms to him, he told me to stop taking the medication immediately. We are trying another drug but the foot pain has not subsided in 2 weeks.
2.3Patient Review
12/12/2010
Timoptic for Closed Angle Glaucoma
I've been using this treatment for a little over three months now. I had used it before but stopped because it burned, however other drugs haven't been effective so I had to start again. It's made my breathing more labored and still burns; on top of that, it also makes me nauseated. Hopefully I can find something else soon that will be more effective with fewer side effects.
2.3Patient Review
12/16/2013
Timoptic for Wide-Angle Glaucoma
Timolol Maleate was not effective in reducing my intraocular pressure. I've tried several other options with no success.
1.7Patient Review
5/29/2009
Timoptic for High Eye Pressure or Glaucoma that May Worsen without Treatment
I experienced worsening depression, feeling like my ears were clogged, and low blood pressure while taking this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about timoptic

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Timoptic eye drops?

"If you experience any of the following side effects, notify your doctor or pharmacist: temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, or headache."

Answered by AI

What are side effects of timolol?

"You may experience some temporary side effects such as blurred vision, burning or stinging sensations in the eyes, watery eyes, dry eyes, the feeling that there is something in your eye, or a headache. If you notice any of these effects persisting or worsening, be sure to notify your doctor or pharmacist."

Answered by AI

Are timolol and Timoptic the same?

"The generic form of Timoptic is called timolol, and there is also a generic form of Xalatan."

Answered by AI

What is Timoptic eye drops used for?

"Timolol eye drops are used to treat increased pressure in the eye that is caused by open-angle glaucoma or a condition called ocular (eye) hypertension. This medicine is a beta-blocker."

Answered by AI

Clinical Trials for Timoptic

Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.
Waitlist Available
Has No Placebo
Johns Hopkins MedicineRisheng Xu, MD, PhDMedtronic
Have you considered Timoptic clinical trials? We made a collection of clinical trials featuring Timoptic, we think they might fit your search criteria.Go to Trials
Have you considered Timoptic clinical trials? We made a collection of clinical trials featuring Timoptic, we think they might fit your search criteria.Go to Trials
Image of Mount Sinai Hospital in New York, United States.

Rimegepant + Zavegepant for Migraine

18+
All Sexes
New York, NY
This study evaluates the effectiveness of rimegepant 75 mg orally disintegrating tablet (ODT) single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments during Emergency Department (ED) encounters. Although these two calcitonin gene-related peptide receptors (CGRP) receptor antagonists are FDA-approved for the indication of acute migraine treatment, past studies have been limited to the outpatient setting. If these medications are effective in the Emergency Department, their delivery methods alone may have advantages over intravenous medications commonly used for acute migraine in EDs, including quicker time to treatment delivery, faster pain relief, and reduced ED length of stay. This investigation is a pilot study to examine rimegepant and zavegepant in an ED, to gain insight on effectiveness in this setting. This study will administer rimegepant 75 mg ODT single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments to 100 patients in the Emergency Department. It is a single center, open-label, non-controlled 2-group clinical trial (allocated 1:1 to rimegepant or zavegepant via pseudo-random assignment). The study will enroll adults in the ED meeting ICHD-3 criteria for migraine or probable migraine, with or without aura.
Phase 4
Recruiting
Mount Sinai HospitalJonathan SchimmelPfizer
Have you considered Timoptic clinical trials? We made a collection of clinical trials featuring Timoptic, we think they might fit your search criteria.Go to Trials
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