Temovate

Alopecia, Psoriasis, Severe Plaque psoriasis + 4 more

Treatment

13 Active Studies for Temovate

What is Temovate

Clobetasol propionate

The Generic name of this drug

Treatment Summary

Clobetasol Propionate is a steroid-based medication used to reduce inflammation. It is more effective than similar drugs and was first described in 1974. It was approved by the FDA in 1985 for use in the United States.

Temovate Scalp Application

is the brand name

image of different drug pills on a surface

Temovate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Temovate Scalp Application

Clobetasol propionate

1990

245

Effectiveness

How Temovate Affects Patients

Corticosteroids work by blocking certain signals in the body that cause inflammation. Clobetasol propionate is usually used twice a day and can last for a long time. Corticosteroids can be taken in higher doses than the body naturally produces, so it has a wide safety range. However, patients should be aware that taking corticosteroids may reduce their body's ability to fight infections and suppress hormones.

How Temovate works in the body

Corticosteroids help reduce inflammation by decreasing blood vessel expansion and preventing white blood cells from travelling to sites of inflammation. They also change the way certain genes are expressed, stopping some proteins from increasing inflammation and promoting proteins that reduce inflammation. Low doses of corticosteroids can reduce inflammation, while high doses weaken the immune system. When taken for an extended period, high doses of glucocorticoids bind to a different type of receptor, which increases sodium levels and decreases potassium levels.

When to interrupt dosage

The advised dose of Temovate is dependent upon the recognized condition, for example Psoriasis, corticosteroid responsive, Inflammatory Dermatosis and Pruritus. The amount of dosage fluctuates, as per the method of delivery (e.g. Topical or Ointment) showcased in the table beneath.

Condition

Dosage

Administration

Pruritus

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Cream - Topical, Cream, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Ointment - Topical, Ointment, Spray - Topical, Liquid, Liquid - Topical, Kit - Topical

Psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Cream - Topical, Cream, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Ointment - Topical, Ointment, Spray - Topical, Liquid, Liquid - Topical, Kit - Topical

Alopecia

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Cream - Topical, Cream, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Ointment - Topical, Ointment, Spray - Topical, Liquid, Liquid - Topical, Kit - Topical

Psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Cream - Topical, Cream, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Ointment - Topical, Ointment, Spray - Topical, Liquid, Liquid - Topical, Kit - Topical

Psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Cream - Topical, Cream, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Ointment - Topical, Ointment, Spray - Topical, Liquid, Liquid - Topical, Kit - Topical

Severe Plaque psoriasis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Cream - Topical, Cream, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Ointment - Topical, Ointment, Spray - Topical, Liquid, Liquid - Topical, Kit - Topical

corticosteroid responsive, Inflammatory Dermatosis

0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg

Topical, Solution, , Solution - Topical, Cream - Topical, Cream, Gel, Gel - Topical, Shampoo, Lotion, Lotion - Topical, Spray, Shampoo - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Emulsion, Emulsion - Topical, Ointment - Topical, Ointment, Spray - Topical, Liquid, Liquid - Topical, Kit - Topical

Warnings

There are 20 known major drug interactions with Temovate.

Common Temovate Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Clobetasol propionate.

Abetimus

Major

The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abetimus.

Temovate Toxicity & Overdose Risk

Taking too much of a glucocorticoid such as clobetasol propionate can lead to the body not having enough of the steroid, as well as other problems. These include cataracts, glaucoma, high blood pressure, water retention, high cholesterol, stomach ulcers, pancreatitis, muscle problems, changes in emotions, skin thinning, allergies, acne, extra hair growth, weak immune system, diabetes, low calcium, low phosphate, and slowed growth. In case of an overdose, the dose may be adjusted or stopped and other treatments may be used to help manage symptoms.

Temovate Novel Uses: Which Conditions Have a Clinical Trial Featuring Temovate?

47 trials are currently assessing the potential of Temovate to treat corticosteroid-responsive Inflammatory Dermatosis, Psoriasis and Alopecia.

Condition

Clinical Trials

Trial Phases

Alopecia

14 Actively Recruiting

Early Phase 1, Not Applicable, Phase 3, Phase 2, Phase 1

Severe Plaque psoriasis

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

corticosteroid responsive, Inflammatory Dermatosis

0 Actively Recruiting

Pruritus

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

Temovate Reviews: What are patients saying about Temovate?

5

Patient Review

10/8/2009

Temovate for Skin Inflammation

I found this treatment to be very effective in treating my Lichen Sclerosis. It burned a lot when I first applied it, but afterwards the itching and pain went away.

5

Patient Review

7/15/2016

Temovate for Atopic Dermatitis

I've tried a lot of different things for my eczema, and this is by far the best.

5

Patient Review

2/15/2008

Temovate for Skin Inflammation

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about temovate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic for Temovate?

"Clobetasol is a much stronger (super-high-potency) corticosteroid than most others. Clobetasol can be found under the following different brand names: Temovate, Temovate E, Cormax, Clobex, Clobex Spray, Clarelux, Cormax Ointment, Cormax Scalp Application, Olux, Olux-E, and Olux-E Foam."

Answered by AI

What is Temovate used for?

"This medication is used to treat various skin conditions by reducing swelling, itching, and redness. It can be used to treat eczema, psoriasis, dermatitis, allergies, and rash."

Answered by AI

Can you buy Temovate over the counter?

"This medication is not available over the counter, you will need a prescription from your doctor to get it."

Answered by AI

Is Temovate cream a steroid?

"The drugs Temovate and Temovate E are both creams that contain steroids, and are used to treat conditions characterized by skin inflammation and itching."

Answered by AI

Clinical Trials for Temovate

Image of Advanced Dermatology & Cosmetic Surgery in Maitland, United States.

Xtresse Serum for Hair Loss

18 - 65
All Sexes
Maitland, FL

The goal of this study is to determine how safe and effective it is to improve hair growth by applying a serum daily on the scalp of men and women with thinning hair. The main aims of this trial are: 1. To confirm using photographic analysis, changes in the quality, volume, and thickness of hair. 2. To gauge patient satisfaction with hair changes and application process. 3. Monitor and report any adverse events associated with the daily usage of Xtressé serum. Participants who qualify will complete 4 visits after voluntary consent has been given. Participants will be given 4 bottles of serum to use during the study. The product will be applied daily over a 4-month period. Photographs and scalp analysis will be performed at each visit to measure changes in hair volume, thickness, and growth. Participants will complete a survey at the end of the study.

Waitlist Available
Has No Placebo

Advanced Dermatology & Cosmetic Surgery (+2 Sites)

Melissa Rayner, MS

Restore Biologics Holdings, Inc. dba Xtressé

Image of Advanced Dermatology & Cosmetic Surgery in Maitland, United States.

Xtressé Gummies for Alopecia

18 - 65
Female
Maitland, FL

The goal of this study is to determine how safe and effective it is to improve hair growth using an active gummy treatment in women with self-perceived thinning hair. The main aims of this trial are: 1. To confirm using photographic analysis, changes in the quality, volume, and thickness of hair. 2. To gauge patient satisfaction with hair changes and application process. 3. Monitor and report any adverse events associated with the daily intake of Xtressé Participants who qualify will complete 5 visits after voluntary consent has been given. Participants will be given a 30-day supply of the gummies at each visit over a 4-month period. Photographs and scalp analysis will be performed at each visit to measure changes in hair volume, thickness, and growth.

Waitlist Available
Has No Placebo

Advanced Dermatology & Cosmetic Surgery (+3 Sites)

Melissa Y Rayner, MS

Restore Biologics Holdings, Inc. dba Xtressé

Image of Advanced Dermatology & Cosmetic Surgery in Maitland, United States.

XVIE for Alopecia

28 - 65
Female
Maitland, FL

The goal of this study is to determine how safe and effective it is to improve hair growth using XVIE solution applied on the scalp of women with self-perceived thinning hair. The main aims of this trial are: 1. To confirm using photographic analysis, changes in the quality, volume, and thickness of hair. 2. To gauge patient satisfaction with hair changes and application process. Participants who qualify will complete 5 to 6 visits after voluntary consent has been given. Participant's scalp will be numbed and the XVIE solution will be applied by microneedling. Photographs will be taken at each visit to measure changes in hair volume, thickness, and growth. Every participant will receive active treatment twice over the 4 month period.

Waitlist Available
Has No Placebo

Advanced Dermatology & Cosmetic Surgery (+1 Sites)

Melissa Y Rayner, MS

Restore Biologics Holdings, Inc. dba Xtressé

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We made a collection of clinical trials featuring Temovate, we think they might fit your search criteria.
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Image of Skin Wellness Dermatology in Birmingham, United States.

Xtressé Supplement and Serum for Alopecia

28 - 65
Female
Birmingham, AL

The goal of this clinical trial is to test how safe and effective it is to improve hair growth using an active gummy and serum combination treatment when compared to an inactive treatment combination in women with self-perceived thinning hair. The main questions this trial aims to answer are: * to confirm using photograph analytics, how much hair growth has increased in a marked area when using active treatment versus inactive treatment, and * participants assessment and satisfaction with the hair growth using scaled assessments. Participants who qualify will be asked to complete 6 to 7 visits after voluntarily consent has been given. The study is divided into two parts. In Part A participants will be randomly given either active or inactive treatment to use over 3 months. After 3 months, all participants will enter Part B of the study and will be given active treatment to use over the final 6 months of the study.

Recruiting
Paid Trial

Skin Wellness Dermatology (+1 Sites)

Danielle Leavitt

Restore Biologics Holdings, Inc. dba Xtressé

Image of Marc Avram MD in New York, United States.

TargetCool + Benev Exosomes for Alopecia

18 - 70
All Sexes
New York, NY

This clinical trial is testing a new approach to help improve hair thinning using a combination of cosmetic treatments. The purpose of the study is to learn whether applying exosomes to the scalp, along with microneedling and a precision cooling device called TargetCool™. This study aims to determine whether this combination approach offers synergistic benefits for individuals with hair thinning. Exosomes are tiny particles that come from stem cells and contain growth factors and other nutrients. They are being studied for their potential to help regenerate skin and hair. TargetCool™ is an FDA-cleared device that uses precision cooling to reduce inflammation and improve comfort. Microneedling is a common, minimally invasive procedure that uses small needles to stimulate the skin and help absorb topical products more effectively. The study will include healthy men (ages 18 to 70) and women (ages approximately 45 to 70) who are not of childbearing potential. A total of 9 to 15 participants will be randomly placed into one of three groups: Group 1: Exosomes with TargetCool™ Group 2: Microneedling followed by exosomes and TargetCool™ Group 3: Microneedling followed by exosomes only Participants will receive four treatments over 9 weeks. Each visit may include microneedling, TargetCool™ treatment, and exosome application depending on group assignment. A small tattoo will be placed on the scalp to help capture consistent photographs, and a special imaging system (Canfield HairMetrix®) will be used to measure hair changes. Participants will return for follow-up visits at 3 and 6 months after the final treatment. The results will help determine whether this combination of cosmetic treatments is safe and beneficial for people experiencing hair thinning.

Waitlist Available
Has No Placebo

Marc Avram MD

Dawn Queen, MD

Recens Medical, Inc.

Have you considered Temovate clinical trials?

We made a collection of clinical trials featuring Temovate, we think they might fit your search criteria.
Go to Trials
Image of University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall in Irvine, United States.

Fractional Photothermolysis for Alopecia

18 - 90
All Sexes
Irvine, CA

This study is being done to evaluate the effects of fractional photothermolysis (known as laser resurfacing) using fractional laser for the induction of hair follicles via skin rejuvenation in subjects with scalp alopecia (specifically, alopecia on the superior forehead at the frontal hairline). Fractional photothermolysis has been shown to be effective in promoting hair growth. The investigators will study 50 subjects who will be treated 6-10 times at 2-4 week intervals. Each participant will have half of their head treated with a laser, either Fraxel DUAL 1550 or Halo by Sciton, and the other half of their head will be left untreated as a control. Half of the individuals will randomly be assigned to the group to be treated with Fraxel DUAL 1550, and the other half will be treated with Halo by Sciton. Visual observation and digital, photographic, non-invasive imaging will be used to compare the treated and untreated area to assess for differences in hair follicle stimulation rates, number and density of hairs. As noted above, the types of lasers we plan to use include the non-ablative fractional laser settings for the Fraxel DUAL 1550 and Halo by Sciton. A fractional laser is a laser that directs an intense burst of laser energy on the skin. The treatment deposits heat deep into the dermis to tighten skin and stimulate collagen remodeling. The necrotic (death of cells or tissue) injury heals rapidly and adverse effects are few. Laser resurfacing is commonly used for rejuvenation of the skin to improve quality, tone, and texture.

Phase < 1
Waitlist Available

University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall