What is Temovate
Clobetasol propionateThe Generic name of this drug
Treatment SummaryClobetasol Propionate is a steroid-based medication used to reduce inflammation. It is more effective than similar drugs and was first described in 1974. It was approved by the FDA in 1985 for use in the United States.
Temovate Scalp Applicationis the brand name
Temovate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Temovate Scalp Application
Clobetasol propionate
1990
244
Effectiveness
How Temovate Affects PatientsCorticosteroids work by blocking certain signals in the body that cause inflammation. Clobetasol propionate is usually used twice a day and can last for a long time. Corticosteroids can be taken in higher doses than the body naturally produces, so it has a wide safety range. However, patients should be aware that taking corticosteroids may reduce their body's ability to fight infections and suppress hormones.
How Temovate works in the bodyCorticosteroids help reduce inflammation by decreasing blood vessel expansion and preventing white blood cells from travelling to sites of inflammation. They also change the way certain genes are expressed, stopping some proteins from increasing inflammation and promoting proteins that reduce inflammation. Low doses of corticosteroids can reduce inflammation, while high doses weaken the immune system. When taken for an extended period, high doses of glucocorticoids bind to a different type of receptor, which increases sodium levels and decreases potassium levels.
When to interrupt dosage
The advised dose of Temovate is dependent upon the recognized condition, for example Psoriasis, corticosteroid responsive, Inflammatory Dermatosis and Pruritus. The amount of dosage fluctuates, as per the method of delivery (e.g. Topical or Ointment) showcased in the table beneath.Condition
Dosage
Administration
Psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
corticosteroid responsive, Inflammatory Dermatosis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Pruritus
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Severe Plaque psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Alopecia
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Warnings
There are 20 known major drug interactions with Temovate.Common Temovate Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abatacept.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clobetasol propionate.
Abetimus
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abetimus.
Temovate Toxicity & Overdose RiskTaking too much of a glucocorticoid such as clobetasol propionate can lead to the body not having enough of the steroid, as well as other problems. These include cataracts, glaucoma, high blood pressure, water retention, high cholesterol, stomach ulcers, pancreatitis, muscle problems, changes in emotions, skin thinning, allergies, acne, extra hair growth, weak immune system, diabetes, low calcium, low phosphate, and slowed growth. In case of an overdose, the dose may be adjusted or stopped and other treatments may be used to help manage symptoms.
Temovate Novel Uses: Which Conditions Have a Clinical Trial Featuring Temovate?
47 trials are currently assessing the potential of Temovate to treat corticosteroid-responsive Inflammatory Dermatosis, Psoriasis and Alopecia.Condition
Clinical Trials
Trial Phases
Alopecia
48 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 4, Phase 1
corticosteroid responsive, Inflammatory Dermatosis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Severe Plaque psoriasis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Temovate Reviews: What are patients saying about Temovate?
5Patient Review
10/8/2009 I found this treatment to be very effective in treating my Lichen Sclerosis. It burned a lot when I first applied it, but afterwards the itching and pain went away.
5Patient Review
7/15/2016 I've tried a lot of different things for my eczema, and this is by far the best.
5Patient Review
2/15/2008Patient Q&A Section about temovate
What is the generic for Temovate?
"Clobetasol is a much stronger (super-high-potency) corticosteroid than most others. Clobetasol can be found under the following different brand names: Temovate, Temovate E, Cormax, Clobex, Clobex Spray, Clarelux, Cormax Ointment, Cormax Scalp Application, Olux, Olux-E, and Olux-E Foam." - Anonymous Online Contributor
Unverified Answer
What is Temovate used for?
"This medication is used to treat various skin conditions by reducing swelling, itching, and redness. It can be used to treat eczema, psoriasis, dermatitis, allergies, and rash." - Anonymous Online Contributor
Unverified Answer
Can you buy Temovate over the counter?
"This medication is not available over the counter, you will need a prescription from your doctor to get it." - Anonymous Online Contributor
Unverified Answer
Is Temovate cream a steroid?
"The drugs Temovate and Temovate E are both creams that contain steroids, and are used to treat conditions characterized by skin inflammation and itching." - Anonymous Online Contributor
Unverified Answer